Results 81 to 90 of about 207,671 (274)

Azomethine Ylides from Tin‐Substituted Cyclic Carbinol Amides: A New Route to Highly Substituted Pyrrolizidines. [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
William H, Pearson, Amber, Dietz, Patrick, Stoy   +2 more
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Kolakoski-(2m,2n) are limit-periodic model sets

, 2003
We consider (generalized) Kolakoski sequences on an alphabet with two even numbers. They can be related to a primitive substitution rule of constant length ell.
Baake, Baake, Baake, Bernd Sing, Dekking, Dworkin, Hutchinson, Kolakoski, Lee, Luck, Martin, Moody, Moody, Radin   +13 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Synthesis and properties of novel star-shaped oligofluorene conjugated systems with BODIPY cores

Beilstein Journal of Organic Chemistry, 2014
Star-shaped conjugated systems with varying oligofluorene arm length and substitution patterns of the central BODIPY core have been synthesised, leading to two families of compounds, T-B1–T-B4 and Y-B1–Y-B4, with T- and Y-shaped motifs, respectively ...
Clara Orofino-Pena, Diego Cortizo-Lacalle, Joseph Cameron, Muhammad T. Sajjad, Pavlos P. Manousiadis, Neil J. Findlay, Alexander L. Kanibolotsky, Dimali Amarasinghe, Peter J. Skabara, Tell Tuttle, Graham A. Turnbull, Ifor D. W. Samuel   +11 more
doaj   +1 more source

Polymer precursors for ceramic matrix composites [PDF]

The synthesis and characterization of a polycyclohexasilane is reported. Because of its cyclic structure, it is anticipated that this polymer might serve as a precursor to SIC having a high char yield with little rearrangement to form small, volatile ...
Kumar, K., Litt, M. H.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

New Insights into the Mechanism of Oxidatively-Induced CO-Substitution Reaction in the Bimetallic FvCo2(CO)4 Gained by Digital Simulation Studies

International Journal of Electrochemical Science, 2015
In this study, digital simulations were performed for cyclic voltammograms (CV) obtained at different scan rates (0.2 to 1.0 V/s) for the oxidatively-promoted CO-substitution reaction by PPh3 in the bimetallic FvCo2(CO)4,1, in CH2Cl2/0.05 M [NBu4][B(C6F5)
Sameerah I. Al-Saeedi, Ali M. Alsalme, Ayman Nafady   +2 more
doaj   +1 more source