Results 1 to 10 of about 518,198 (339)

Functional insight into cyclin-dependent kinase (CDK)7 via chemical inhibition of the priority fungal pathogen <i>Cryptococcus neoformans</i>. [PDF]

mBio
Sethiya P, Desmarini D, Bowring BG, Cesar K, Boucher MJ, Wei AL, Madhani HD, Crossett B, Connelly A, Halliday CL, Chen SC-A, Lai J, Wong KH, Djordjevic JT.   +13 more
europepmc   +2 more sources

Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells

Pharmaceutical Biology, 2023
Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein.
Rui-Yi Yang, Jia-Yi Tan, Zhe Liu, Xiao-Ling Shen, Ying-Jie Hu   +4 more
doaj   +1 more source

The Cyclin-dependent kinase 1: more than a cell cycle regulator

British Journal of Cancer, 2023
The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade.
Giorgia Massacci, Livia Perfetto, F. Sacco   +2 more
semanticscholar   +1 more source

Exploring cell cycle-mediated regulations of glycolysis in budding yeast

Frontiers in Microbiology, 2023
Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang, Yanfei Zhang, Matteo Barberis, Matteo Barberis, Matteo Barberis   +4 more
doaj   +1 more source

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis

Cells, 2023
The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj   +1 more source

Research progress on cell cycle regulation-related molecules in the development of oral squamous cell carcinoma

Kouqiang hemian waike zazhi, 2023
Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial cancer. In‐depth research on the regulatory mechanism of cell cycle regulation‐related molecules has revealed that these molecules play various roles in the incidence and ...
HOU Zeyu, TANG Jinru, LI Longjiang
doaj   +1 more source

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

Cyclin-Dependent Kinase

Definitions, 2020
Cyclin-dependent eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.
Researcher Código, Orcid A.1, Situación, Artero Formación, Licenciatura, Grado, Doctorado   +6 more
semanticscholar   +1 more source

Immunohistochemical Expression of p27^Kip1, p57^Kip2, Cyclin D1, Nestin, and Ki-67 in Ependymoma

Brain Sciences, 2022
p27 and p57 are tumor suppressors that are dysregulated in many cancers. We investigated the immunohistochemical expression of p27 and p57 in ependymoma, with a secondary emphasis on cyclin D1, nestin, and Ki-67.
Shahad Iqneibi, Jamil Nazzal, Basma Owda, Hala Sultan, Runa Amoudi, Justin Z. Amarin, Sura Al-Ghnimat, Mamoun Ahram, Maysa Al-Hussaini   +8 more
doaj   +1 more source

A review on the role of cyclin dependent kinases in cancers

Cancer Cell International, 2022
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
S. Ghafouri‐Fard, Tayyebeh Khoshbakht, B. Hussen, Peixin Dong, N. Gassler, M. Taheri, A. Baniahmad, N. A. Dilmaghani   +7 more
semanticscholar   +1 more source