Results 1 to 10 of about 383,210 (284)
D-type cyclin-dependent kinase activity in mammalian cells. [PDF]
Molecular and Cellular Biology, 1994 D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells. Lysis of rodent fibroblasts, mouse macrophages, or myeloid cells with Tween 20 followed by precipitation with antibodies to cyclins D1, D2, and D3 or to their ...
H Matsushime +5 more
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Cyclin-dependent kinases [PDF]
Genome Biology, 2014 Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity.
Marcos Malumbres
semanticscholar +4 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1996 Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence.
David A. Alcorta +5 more
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Cyclin-dependent kinase control of motile ciliogenesis
eLife, 2018 Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Eszter K Vladar +7 more
doaj +5 more sources
Cancer therapy by cyclin-dependent kinase inhibitors (CDKIs) [PDF]
EXCLI Journal : Experimental and Clinical SciencesA major characteristic of cancer is dysregulated cell division, which results in aberrant growth of cells. Consequently, medicinal targets that prevent cell division would be useful in the fight against cancer. The primary regulator of proliferation is a
Ali Hassanzadeh +5 more
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Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells
Pharmaceutical Biology, 2023 Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein.
Rui-Yi Yang +4 more
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The Renaissance of Cyclin Dependent Kinase Inhibitors [PDF]
Cancers, 2022 Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered expression and availability of CDKs strongly contribute to impaired cell proliferation, a hallmark of cancer. In recent years, targeted inhibition of CDKs has shown considerable therapeutic benefit in a variety of tumor entities. Their success is reflected
Ettl, Tobias +2 more
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Exploring cell cycle-mediated regulations of glycolysis in budding yeast
Frontiers in Microbiology, 2023 Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang +4 more
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Cells, 2023 The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
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Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source