Results 11 to 20 of about 504,196 (405)

Cyclin-dependent kinases [PDF]

Genome Biology, 2014
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity.
Marcos Malumbres
semanticscholar   +4 more sources

Cyclin-dependent kinase control of motile ciliogenesis

eLife, 2018
Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Eszter K Vladar, Miranda B Stratton, Maxwell L Saal, Glicella Salazar-De Simone, Xiangyuan Wang, Debra Wolgemuth, Tim Stearns, Jeffrey D Axelrod   +7 more
doaj   +5 more sources

The Renaissance of Cyclin Dependent Kinase Inhibitors [PDF]

Cancers, 2022
Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered expression and availability of CDKs strongly contribute to impaired cell proliferation, a hallmark of cancer. In recent years, targeted inhibition of CDKs has shown considerable therapeutic benefit in a variety of tumor entities. Their success is reflected
Ettl, Tobias, Schulz, Daniela, Bauer, Richard J.   +2 more
openaire   +3 more sources

Cyclin-dependent kinase inhibitors in malignant hematopoiesis

Frontiers in Oncology, 2022
The cell-cycle is a tightly orchestrated process where sequential steps guarantee cellular growth linked to a correct DNA replication. The entire cell division is controlled by cyclin-dependent kinases (CDKs). CDK activation is balanced by the activating
Alessia Schirripa, Veronika Sexl, Karoline Kollmann   +2 more
doaj   +1 more source

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough, Berezney, Brown, Cardoso, Chevalier, Cook, Coverley, Coverley, den Hollander, Dijkwel, Djeliova, Fujita, Furstenthal, Geng, Geng, Harper, Hozak, Krude, Lowe, Mailand, Mitsui, Moore, Parisi, Radichev, Sherr, Stoeber, Su, Takeda, Tatsumi, Wilmes, Wohlschlegel   +30 more
core   +3 more sources

CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]

, 2013
Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
A Sourirajan, AC Porter, AL Marston, Bela Novak, BH Lee, BN Tomson, CM Yellman, D D'amours, DA Mohl, E Queralt, E Queralt, F Bizzari, F Hu, F Liang, F Stegmeier, F Stegmeier, GW Kerr, GW Kerr, Katherine Louise Tibbles, KE Sawarynski, KR Benjamin, M Moore, M Petronczki, M Sullivan, ME Shin, N Grandin, Prakash Arumugam, R Azzam, R Visintin, R Visintin, RJ Kamieniecki, S Jensen, SL Jaspersen, Sourav Sarkar, TM Carlile, W Shou, W Shou, Y Zhai, Yanchang Wang   +38 more
core   +7 more sources

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

Frontiers in Cell and Developmental Biology, 2019
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene.
Monika Nováková, Marek Hampl, Marek Hampl, Dávid Vrábel, Jan Procházka, Jan Procházka, Silvia Petrezselyová, Silvia Petrezselyová, Michaela Procházková, Michaela Procházková, Radislav Sedláček, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Marcela Buchtová, Jiří Kohoutek   +19 more
doaj   +1 more source

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

Science, 2019
Revised view of anticancer drug mechanism A crystal structure of the active form of cyclin-dependent kinase 4 (CDK4) provides insight into regulation of the cell cycle and the mechanism of action of a drug used for breast cancer therapy.
Keelan Z. Guiley, J. W. Stevenson, Kevin Lou, Krister J. Barkovich, Vishnu Kumarasamy, Tilini U. Wijeratne, K. Bunch, S. Tripathi, E. Knudsen, A. Witkiewicz, K. Shokat, S. M. Rubin   +11 more
semanticscholar   +1 more source

Prediction of cyclin-dependent kinase phosphorylation substrates. [PDF]

PLoS ONE, 2007
Protein phosphorylation, mediated by a family of enzymes called cyclin-dependent kinases (Cdks), plays a central role in the cell-division cycle of eukaryotes.
Emmanuel J Chang, Rashida Begum, Brian T Chait, Terry Gaasterland   +3 more
doaj   +1 more source

Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]

, 2003
Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A., Eppenberger, H. M., Magyar, J. P., Wagner, E., Weikert, C., Wightman, L.   +5 more
core   +1 more source