Results 11 to 20 of about 518,198 (339)

Cyclin-dependent kinase inhibitors in malignant hematopoiesis

Frontiers in Oncology, 2022
The cell-cycle is a tightly orchestrated process where sequential steps guarantee cellular growth linked to a correct DNA replication. The entire cell division is controlled by cyclin-dependent kinases (CDKs). CDK activation is balanced by the activating
Alessia Schirripa, Veronika Sexl, Karoline Kollmann   +2 more
doaj   +1 more source

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]

, 2010
The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire, Fan, Ming, Li, Jian Jian, Nantajit, Danupon, Reed, John C, Wen, Yunfei   +5 more
core   +19 more sources

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough, Berezney, Brown, Cardoso, Chevalier, Cook, Coverley, Coverley, den Hollander, Dijkwel, Djeliova, Fujita, Furstenthal, Geng, Geng, Harper, Hozak, Krude, Lowe, Mailand, Mitsui, Moore, Parisi, Radichev, Sherr, Stoeber, Su, Takeda, Tatsumi, Wilmes, Wohlschlegel   +30 more
core   +3 more sources

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

Frontiers in Cell and Developmental Biology, 2019
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene.
Monika Nováková, Marek Hampl, Marek Hampl, Dávid Vrábel, Jan Procházka, Jan Procházka, Silvia Petrezselyová, Silvia Petrezselyová, Michaela Procházková, Michaela Procházková, Radislav Sedláček, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Marcela Buchtová, Jiří Kohoutek   +19 more
doaj   +1 more source

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

Science, 2019
Revised view of anticancer drug mechanism A crystal structure of the active form of cyclin-dependent kinase 4 (CDK4) provides insight into regulation of the cell cycle and the mechanism of action of a drug used for breast cancer therapy.
Keelan G. Guiley, J. W. Stevenson, Kevin Lou, Krister J. Barkovich, Vishnu Kumarasamy, Tilini U. Wijeratne, K. Bunch, S. Tripathi, E. Knudsen, A. Witkiewicz, K. Shokat, S. M. Rubin   +11 more
semanticscholar   +1 more source

Prediction of cyclin-dependent kinase phosphorylation substrates. [PDF]

PLoS ONE, 2007
Protein phosphorylation, mediated by a family of enzymes called cyclin-dependent kinases (Cdks), plays a central role in the cell-division cycle of eukaryotes.
Emmanuel J Chang, Rashida Begum, Brian T Chait, Terry Gaasterland   +3 more
doaj   +1 more source

Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. [PDF]

, 2015
Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by ...
de la Cruz, Aida Flor A, Edgar, Bruce A, Icreverzi, Amalia, Walker, David W   +3 more
core   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G., Dunn, Michael, Jowsey, Paul, Meyer, Stephanie K., Porter, Andrew, Vidier, Daniel S.   +5 more
core   +2 more sources

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Virus Research, 2023
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for ...
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall   +12 more
doaj   +1 more source