Results 11 to 20 of about 383,210 (284)

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

Cyclin-Dependent Kinase

Definitions, 2020
Cyclin-dependent eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.
Researcher Código, Orcid A.1, Situación, Artero Formación, Licenciatura, Grado, Doctorado   +6 more
semanticscholar   +1 more source

Immunohistochemical Expression of p27^Kip1, p57^Kip2, Cyclin D1, Nestin, and Ki-67 in Ependymoma

Brain Sciences, 2022
p27 and p57 are tumor suppressors that are dysregulated in many cancers. We investigated the immunohistochemical expression of p27 and p57 in ependymoma, with a secondary emphasis on cyclin D1, nestin, and Ki-67.
Shahad Iqneibi, Jamil Nazzal, Basma Owda, Hala Sultan, Runa Amoudi, Justin Z. Amarin, Sura Al-Ghnimat, Mamoun Ahram, Maysa Al-Hussaini   +8 more
doaj   +1 more source

Cyclin-dependent kinase inhibitors in malignant hematopoiesis

Frontiers in Oncology, 2022
The cell-cycle is a tightly orchestrated process where sequential steps guarantee cellular growth linked to a correct DNA replication. The entire cell division is controlled by cyclin-dependent kinases (CDKs). CDK activation is balanced by the activating
Alessia Schirripa, Veronika Sexl, Karoline Kollmann   +2 more
doaj   +1 more source

Prediction of cyclin-dependent kinase phosphorylation substrates. [PDF]

PLoS ONE, 2007
Protein phosphorylation, mediated by a family of enzymes called cyclin-dependent kinases (Cdks), plays a central role in the cell-division cycle of eukaryotes.
Emmanuel J Chang, Rashida Begum, Brian T Chait, Terry Gaasterland   +3 more
doaj   +1 more source

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

Frontiers in Cell and Developmental Biology, 2019
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene.
Monika Nováková, Marek Hampl, Marek Hampl, Dávid Vrábel, Jan Procházka, Jan Procházka, Silvia Petrezselyová, Silvia Petrezselyová, Michaela Procházková, Michaela Procházková, Radislav Sedláček, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Marcela Buchtová, Jiří Kohoutek   +19 more
doaj   +1 more source

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

Science, 2019
Revised view of anticancer drug mechanism A crystal structure of the active form of cyclin-dependent kinase 4 (CDK4) provides insight into regulation of the cell cycle and the mechanism of action of a drug used for breast cancer therapy.
Keelan Z. Guiley, J. W. Stevenson, Kevin Lou, Krister J. Barkovich, Vishnu Kumarasamy, Tilini U. Wijeratne, K. Bunch, S. Tripathi, E. Knudsen, A. Witkiewicz, K. Shokat, S. M. Rubin   +11 more
semanticscholar   +1 more source

Cyclin‐dependent kinase‐5 in neurodegeneration [PDF]

Journal of Neurochemistry, 2004
AbstractCyclin‐dependent kinase‐5 (CDK5) is predominantly active in the nervous system and it is well established that CDK5 is essential in neuronal development. In addition to its recognized role in development, there is increasing evidence that CDK5 may be involved in the pathogenesis of several neurodegenerative disorders.
Gail V.W. Johnson, Shirley B. Shelton
openaire   +3 more sources

Multiple cutaneous melanomas associated with gastric and brain metastases [PDF]

Anais Brasileiros de Dermatologia, 2016
The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases.
Lara Caroline Grander, Fernanda Cabral, Alice Paixão Lisboa, Gabrielle Vale, Carlos Baptista Barcaui, Juan Manuel Pineiro Maceira   +5 more
doaj   +1 more source

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

Journal of Medicinal Chemistry, 2016
Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly 2 decades due to their widely varied and critical functions within the cell.
Yogesh A Sonawane, Margaret A. Taylor, J. V. Napoleon, Sandeep Rana, Jacob I. Contreras, A. Natarajan   +5 more
semanticscholar   +1 more source