Results 11 to 20 of about 386,039 (382)

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America, 1996
Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence.
Alcorta Da, Y. Xiong, Dale L. Phelps, G. Hannon, D. Beach, Barrett Jc   +5 more
semanticscholar   +2 more sources

D-type cyclin-dependent kinase activity in mammalian cells [PDF]

Molecular and Cellular Biology, 1994
H. Matsushime, D. Quelle, S. Shurtleff, M. Shibuya, C. Sherr, J. Kato   +5 more
semanticscholar   +2 more sources

Cancer therapy by cyclin-dependent kinase inhibitors (CDKIs): bench to bedside. [PDF]

EXCLI J
A major characteristic of cancer is dysregulated cell division, which results in aberrant growth of cells. Consequently, medicinal targets that prevent cell division would be useful in the fight against cancer. The primary regulator of proliferation is a
Hassanzadeh A, Shomali N, Kamrani A, Soltani-Zangbar MS, Nasiri H, Akbari M.   +5 more
europepmc   +2 more sources

Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells

Pharmaceutical Biology, 2023
Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein.
Rui-Yi Yang, Jia-Yi Tan, Zhe Liu, Xiao-Ling Shen, Ying-Jie Hu   +4 more
doaj   +1 more source

Exploring cell cycle-mediated regulations of glycolysis in budding yeast

Frontiers in Microbiology, 2023
Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang, Yanfei Zhang, Matteo Barberis, Matteo Barberis, Matteo Barberis   +4 more
doaj   +1 more source

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis

Cells, 2023
The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj   +1 more source

Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]

EPTCS 385, 2023, pp. 260-273, 2023
Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv   +1 more source

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family.
Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong, Zhiyong Yang   +5 more
doaj   +1 more source

Cyclin-Dependent Kinase

Definitions, 2020
Cyclin-dependent eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.
Researcher Código, Orcid A.1, Situación, Artero Formación, Licenciatura, Grado, Doctorado   +6 more
semanticscholar   +1 more source

Immunohistochemical Expression of p27^Kip1, p57^Kip2, Cyclin D1, Nestin, and Ki-67 in Ependymoma

Brain Sciences, 2022
p27 and p57 are tumor suppressors that are dysregulated in many cancers. We investigated the immunohistochemical expression of p27 and p57 in ependymoma, with a secondary emphasis on cyclin D1, nestin, and Ki-67.
Shahad Iqneibi, Jamil Nazzal, Basma Owda, Hala Sultan, Runa Amoudi, Justin Z. Amarin, Sura Al-Ghnimat, Mamoun Ahram, Maysa Al-Hussaini   +8 more
doaj   +1 more source