Results 201 to 210 of about 504,196 (405)

The Pho85 kinase, a member of the yeast cyclin‐ dependent kinase (Cdk) family, has a regulation mechanism different from Cdks functioning throughout the cell cycle [PDF]

, 1999
Masafumi Nishizawa, Kohji Suzuki, Marie Fujino, Tomoko Oguchi, Akio Toh‐e   +4 more
openalex   +1 more source

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high‐grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

Cancer Communications, EarlyView.
Monika Raab, Balázs Győrffy, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Margareta Kolaric, Matthias Ebert, Khayal Gasimli, Sven Becker, Mourad Sanhaji, Klaus Strebhardt   +10 more
wiley   +1 more source

DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids

European Journal of Organic Chemistry, Accepted Article.
This report describes a general and simple method for the one‐pot direct N‐acylation of sulfoximines with carboxylic acids using our previously developed 4‐(N,N‐dimethylamino)pyridine N‐oxide (DMAPO)/di‐tert‐butyl dicarbonate (Boc2O) system. The method can be performed under mild low‐temperature reaction conditions and has a wide substrate scope.
Atsushi Umehara, Sukenao Kawai, Makoto Sasaki   +2 more
wiley   +1 more source

The history and future of targeting cyclin-dependent kinases in cancer therapy

Nature reviews. Drug discovery, 2015
U. Asghar, A. Witkiewicz, N. Turner, E. Knudsen   +3 more
semanticscholar   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

Clinical significance of cyclin-dependent kinase inhibitor 3 in hepatocellular carcinoma. [PDF]

Mol Clin Oncol
Liu X, Chang K, Liu J.
europepmc   +1 more source

MiR‐29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation

Exploration, EarlyView.
Our findings suggest that miR‐29a/b is a critical regulator of CD8+ T cells, possibly via the Ifng‐JAK‐STAT signal in IBD patients and the upregulation of miR‐29a/b relieves the development of significant inflammation in the colon of DSS‐induced colitis‐affected mice.
Yingying Lin, Yuqi Wang, Yuning Zhang, Yao Lu, Juan Chen, Yongting Luo, Jian He, Qingfeng Luo, Heng Quan, Weiru Yu, Yujia Luo, Peng Xue, Yi Xue, Xiaoya Lin, Rui Ding, Lining Chen, Yiran Wang, Zenghui Xia, Liang Zhao, Hao Zhang, Ran Wang, Qingyu Wang, Xifan Wang, Jiaqi Su, Fazheng Ren, Cong Lv, Yixuan Li, Huiyuan Guo   +27 more
wiley   +1 more source

Pembrolizumab promotes degradation of cyclin dependent kinase 6 and suppresses ovarian cancer progression in vitro. [PDF]

Sci Rep
Wu Y, Xu Z, Kou Z, Ye Q, Chen L, Gou B.
europepmc   +1 more source

Exploring the Potential of Tsuruazuki Bean as a Functional Food to Curb Obesity Using Human Amniotic Epithelial Cells and 3T3‐L1 Preadipocytes

Food Frontiers, EarlyView.
Obesity is a global health problem that requires research and regulatory attention. This research aims to investigate transcriptome‐wide changes induced by Vigna umbellata (Tsuruazuki) using a stem cell‐based tool and preadipocytes to explore its untapped potential as a functional food for anti‐obesity applications.
Elda Nurafnie Ibnu Rasid, Farhana Ferdousi, Kazunori Sasaki, Kyoko Toda, Shinya Takahashi, Mari Maeda‐Yamamoto, Hiroko Isoda   +6 more
wiley   +1 more source

Inhibition of E2F Activity by the Cyclin-Dependent Protein Kinase Inhibitor p21 in Cells Expressing or Lacking a Functional Retinoblastoma Protein

, 1996
Goberdhan P. Dimri, Makoto Nakanishi, Pierre‐Yves Desprez, James R. Smith, Judith Campisi   +4 more
openalex   +1 more source