Results 201 to 210 of about 518,198 (339)

Supplementary Figures S1-4 from NeoPalAna: Neoadjuvant Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, and Anastrozole for Clinical Stage 2 or 3 Estrogen Receptor–Positive Breast Cancer

, 2023
X. Cynthia, Feng Gao, Jingqin Luo, Donald W. Northfelt, Matthew P. Goetz, Andres Forero, Jeremy Hoog, Michael Naughton, Foluso O. Ademuyiwa, Rama Suresh, Karen Anderson, Julie A. Margenthaler, Rebecca Aft, Timothy J. Hobday, Timothy J. Moynihan, William E. Gillanders, Amy Cyr, Timothy J. Eberlein, Tina J. Hieken, Helen Krontiras, Zhanfang Guo, Michelle V. Lee, Nicholas C. Spies, Zachary L. Skidmore, Obi L. Griffith, Malachi Griffith, Shana Thomas, Caroline Bumb, Kiran Vij, Cynthia Huang Bartlett, María Koehler, Hussam Al‐Kateb, Souzan Sanati, Matthew J. Ellis   +33 more
openalex   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Preclinical Evaluation of the Efficacy of the Cyclin-Dependent Kinase Inhibitor Ribociclib in Combination with Letrozole against Patient-Derived Glioblastoma Cells. [PDF]

Mol Cancer Ther
Gadgil SN, Karve AS, Gudelsky GA, Gabani BB, Kulkarni SP, Phoenix TN, Medvedovic M, Medvedovic M, Plas DR, Wise-Draper TM, Sengupta S, DasGupta B, Yogendran L, Desai PB.   +13 more
europepmc   +1 more source

Cyclin-dependent kinase 5 is required for normal cerebellar development

, 2012
Ayumi Kumazawa, Naoki Mita, Motoyuki Hirasawa, Tomoko Adachi, Hiromi Suzuki, Nasrin Shafeghat, Ashok B. Kulkarni, Katsuhiko Mikoshiba, Takafumi Inoue, Toshio Ohshima   +9 more
openalex   +2 more sources

Cell Cycle and Cancer: Genetic Analysis of the Role of Cyclin-dependent Kinases [PDF]

, 2005
Mariano Barbacid, Sagrario Ortega, Rocı́o Sotillo, Junko Odajima, Alberto Martín, David Santamarı́a, Pierre Dubus, Marcos Malumbres   +7 more
openalex   +1 more source

Supplementary Figure 6 from Inhibition of NF-κB–Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells

, 2023
Emilio Cosimo, Alison M. McCaig, Luke J.M. Carter-Brzezinski, Helen Wheadon, Michael T. Leach, Karine Le Ster, Christian Berthou, Émilie Durieu, Nassima Oumata, Hervé Galons, Laurent Meijer, Alison M. Michie   +11 more
openalex   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer. [PDF]

J Biol Chem
Zhu M, Huang L, Sun S, Chen M, Cai J, Zhang Y, Wang L, Cai L, Peng M.   +8 more
europepmc   +1 more source

Data from Inhibition of NF-κB–Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells

, 2023
Emilio Cosimo, Alison M. McCaig, Luke J.M. Carter-Brzezinski, Helen Wheadon, Michael T. Leach, Karine Le Ster, Christian Berthou, Émilie Durieu, Nassima Oumata, Hervé Galons, Laurent Meijer, Alison M. Michie   +11 more
openalex   +1 more source

Characterization of molecular and cellular functions of the cyclin‐dependent kinase CDK9 using a novel specific inhibitor

British Journal of Pharmacology, 2014
T. Albert, C. Rigault, J. Eickhoff, K. Baumgart, Claudia Antrecht, B. Klebl, Gerhard Mittler, M. Meisterernst   +7 more
semanticscholar   +1 more source