Results 241 to 250 of about 518,198 (339)

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer's Disease. [PDF]

Biomolecules
Kumari S, Singh AK, Kumar M, Pradhan R, Rao AR, Yadav Y, Kumar P, Haldar P, Kaur P, Dey S.   +9 more
europepmc   +1 more source

Cyclin-dependent kinase 9 is required for the survival of adult Drosophila melanogaster glia [PDF]

, 2017
Lynette C. Foo
openalex   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays. [PDF]

RSC Chem Biol
Heier JL, Boselli DJ, Parker LL.
europepmc   +1 more source

Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21^WAF1/CIP1 [PDF]

, 2009
Nina‐Naomi Kreis, Katharina Sommer, Mourad Sanhaji, Andrea Krämer, Yves Matthess, Manfred Kaufmann, Klaus Strebhardt, Juping Yuan   +7 more
openalex   +1 more source

Cyclin-dependent kinase inhibitor therapy for hematologic malignancies

Expert Opinion on Investigational Drugs, 2013
P. Bose, G. Simmons, S. Grant
semanticscholar   +1 more source

The Evolution of Pneumocystis jirovecii Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) remains a modern‐day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk‐stratified approaches to PJP prophylaxis ...
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Cyclin-Dependent Kinase 2 Activity after X-irradiation of Apoptosis-Sensitive and -Resistant Mouse Lymphonia Cell Lines

, 1999
Masaaki Tatsuka, Hidehiko Kawai, Fumio Suzuki, Tomohisa Kato, Mituo Ikenaga   +4 more
openalex   +1 more source

The Plant-Specific Cyclin-Dependent Kinase CDKB1;1 and Transcription Factor E2Fa-DPa Control the Balance of Mitotically Dividing and Endoreduplicating Cells in Arabidopsis [PDF]

, 2004
Véronique Boudolf, Kobe Vlieghe, Gerrit T.S. Beemster, Zoltán Magyar, Juan Antonio Torres Acosta, Sara Maes, Els Van Der Schueren, Dirk Inzé, Lieven De Veylder   +8 more
openalex   +1 more source