Results 241 to 250 of about 386,039 (382)

Inhibition of E2F Activity by the Cyclin-Dependent Protein Kinase Inhibitor p21 in Cells Expressing or Lacking a Functional Retinoblastoma Protein

, 1996
Goberdhan P. Dimri, Makoto Nakanishi, Pierre‐Yves Desprez, James R. Smith, Judith Campisi   +4 more
openalex   +1 more source

The Pho85 kinase, a member of the yeast cyclin‐ dependent kinase (Cdk) family, has a regulation mechanism different from Cdks functioning throughout the cell cycle [PDF]

, 1999
Masafumi Nishizawa, Kohji Suzuki, Marie Fujino, Tomoko Oguchi, Akio Toh‐e   +4 more
openalex   +1 more source

Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

ChemistryOpen, EarlyView.
Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust, Afrooz Anbaraki, Zahra Dindar, Atiyeh Ghasemi, Ali Akbar Saboury, Saeed Rayati, Arefeh Seyedarabi   +6 more
wiley   +1 more source

The novel selective inhibitors of cyclin-dependent kinase 4/6: in vitro and in silico study. [PDF]

Sci Rep
Susanti NMP, Kurniawan F, Damayanti S, Kartasasmita RE, Tjahjono DH.   +4 more
europepmc   +1 more source

The cyclin‐dependent kinase inhibitors p18^INK4c and p19^INK4d are highly expressed in CD34⁺ progenitor and acute myeloid leukaemic cells but not in normal differentiated myeloid cells [PDF]

, 1999
Mario P. Tschan, U Peters, Jean-François Cajot, Daniel Betticher, Martin F. Fey, A Tobler   +5 more
openalex   +1 more source

BMP signalling in colorectal cancer: losing the yin to WNTs yang

The Journal of Pathology, EarlyView.
Abstract Colorectal cancer (CRC) is the third most common form of cancer globally, and arises from the hyperproliferation of epithelial cells in the intestine. The architecture and maintenance of these cells is governed by two major signalling pathways working in a counter‐gradient: the stem cell WNT signalling pathway, and the prodifferentiation bone ...
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them. [PDF]

Breast
Foffano L, Cucciniello L, Nicolò E, Migliaccio I, Noto C, Reduzzi C, Malorni L, Cristofanilli M, Gerratana L, Puglisi F.   +9 more
europepmc   +1 more source

Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK)

, 1998
Mahitosh Mandal, Debdutta Bandyopadhyay, Thea M. Goepfert, Rakesh Kumar   +3 more
openalex   +1 more source

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2 [PDF]

ACS Med Chem Lett
Bashore FM, Min SM, Chen X, Howell S, Rinderle CH, Morel G, Silvaroli JA, Wells CI, Bunnell BA, Drewry DH, Pabla NS, Ultanir SK, Bullock AN, Axtman AD.   +13 more
europepmc   +2 more sources

Retinoma: An overview

Pediatric Investigation, EarlyView.
Retinoma, a benign tumor caused by biallelic retinoblastoma gene (RB1) inactivation, offers key insights into retinoblastoma development and oncogenesis. This review explores its molecular genetics, clinical features, diagnosis, management, and potential implications for advancing the prevention and treatment of retinoblastoma.
Panagiotis N. Toumasis, Ashwin Mallipatna, Timothy W. Corson, Helen Dimaras   +3 more
wiley   +1 more source