Results 271 to 280 of about 386,039 (382)

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

Palbociclib-induced Toxic Epidermal Necrolysis: A Case Report with Review of All Cases Secondary to Cyclin-dependent Kinase 4/6 Inhibitors. [PDF]

Acta Derm Venereol
Devoldere A, Vanhaecke C, Soibinet P, Azzouz B, Viguier M.   +4 more
europepmc   +1 more source

Control of the G1 phase cyclin-dependent kinases by mitogenic growth factors and the extracellular matrix

, 1997
Richard K. Assoian
openalex   +1 more source

Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

Aging Cell, EarlyView.
The molecular underpinnings of divergent cognitive trajectories in aging remain unresolved. Using high‐resolution behavioral testing to cognitively stratify aged male mice into ‘intact’ and ‘impaired’ subgroups, we show that reactive gliosis and cellular senescence are key determinants of disparities in cognitive function with age.
Matthew P. Baier, Rojina Ranjit, Daniel B. Owen, Jenna L. Wilson, Megan A. Stiles, Anthony M. Masingale, Zachary Thomas, Anne Bredegaard, David M. Sherry, Sreemathi Logan   +9 more
wiley   +1 more source

Timing of Dose Reductions and Survival Outcomes in Metastatic Breast Cancer Patients Treated with Cyclin-Dependent Kinase 4/6 Inhibitors. [PDF]

Curr Oncol
Kubilay Tolunay P, Kurt İnci B, Usta Ş, Topkaç A, Karabuğa B, Aydemir E, Öner İ, Akay Hacan B, Ateş Ö, Karaçin C, Yalçıntaş Arslan Ü.   +10 more
europepmc   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Aging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik, Ádám Nyúl‐Tóth, Rafal Gulej, Roland Patai, Tamas Kiss, Jordan Delfavero, Raghavendra Y. Nagaraja, Priya Balasubramanian, Santny Shanmugarama, Anna Ungvari, Siva Sai Chandragiri, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Andriy Yabluchanskiy, Sharon Negri, Stefano Tarantini, Shannon Conley, Tae Gyu Oh, Zoltan Ungvari, Anna Csiszar   +20 more
wiley   +1 more source

Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study. [PDF]

Medicina (Kaunas)
Doğan A, İlhan N, Akdağ G, Yıldırım S, Seyyar M, Yüksel Yaşar Z, Erölmez HN, Sürmeli H, Öztosun B, Sever ÖN, Odabaş H, Yıldırım ME, Çabuk D, Turan N, Gümüş M.   +14 more
europepmc   +1 more source

Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF‐A165B Expression

Aging Cell, EarlyView.
The underlying mechanisms of age‐related revascularization impairment are not clear. Our research firstly identified that macrophages were more senescent in the ischemic skeletal muscle of old mice and senescent macrophages could inhibit revascularization.
Minghong Chen, Junyu Chen, Yu Liu, Xuerui Wang, Meilian Yao, Jing Chen, Jian Zhang, Qun Huang   +7 more
wiley   +1 more source

Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase. [PDF]

Hum Cell
Hoshino H, Akama TO, Inoue D, Moritani S, Shigeto S, Matsuda K, Yoshida H, Yonemoto N, Fukushima M, Yoshida Y, Kobayashi M.   +10 more
europepmc   +1 more source

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source