Results 21 to 30 of about 383,210 (284)
Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy.
Cancer Discovery, 2020 Drugs targeting the cell cycle-regulatory cyclin-dependent kinase (CDK) 4 and 6 have been approved for the treatment of hormone receptor-positive breast cancer, and inhibitors targeting other cell-cycle CDKs are currently in clinical trials.
J. Chou +4 more
semanticscholar +1 more source
Cyclin-dependent kinase 1–dependent activation of APC/C ubiquitin ligase
Science, 2016 Phosphorylation cues exit from mitosis The entry and exit from the cell cycle are controlled by waves of protein phosphorylation and degradation events. Fujimitsu et al.
K. Fujimitsu, M. Grimaldi, H. Yamano
semanticscholar +1 more source
Palbociclib in breast cancer neoadjuvant setting
Autopsy and Case Reports, 2021 Cyclin-dependent kinase 4/6 inhibitors represent a major advance in breast cancer treatment, emerging as the standard of care of the initial treatment of hormone receptor-positive and HER2-negative metastatic breast cancer.
Sílvia Alexandra Cabral Duarte +3 more
doaj
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]
PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008 Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv +1 more source
Prediction of kinase inhibitor response using activity profiling, in-vitro screening, and elastic net regression [PDF]
BMC Systems Biology 2014, 8:74, 2013 Many kinase inhibitors have been approved as cancer therapies. Recently, libraries of kinase inhibitors have been extensively profiled, thus providing a map of the strength of action of each compound on a large number of its targets. These profiled libraries define drug-kinase networks that can predict the effectiveness of new untested drugs and ...
arxiv +1 more source
Tumor Biology, 2018 Objectives: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation.
Girolamo Spagnoletti +8 more
doaj +1 more source
Viruses, 2015 Replication of human cytomegalovirus (HCMV) is characterized by a tight virus-host cell interaction. Cyclin-dependent protein kinases (CDKs) are functionally integrated into viral gene expression and protein modification.
Mirjam Steingruber +7 more
doaj +1 more source
Regulation of Sox6 by cyclin dependent kinase 5 in brain. [PDF]
PLoS ONE, 2014 Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration.
Parvathi Rudrabhatla +3 more
doaj +1 more source
Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics
Molecular Pharmacology, 2015 Cyclin-dependent kinases (CDKs) have been considered promising drug targets for a number of years, but most CDK inhibitors have failed rigorous clinical testing.
Mary E. Law +3 more
semanticscholar +1 more source
Complexity in cancer biology: is systems biology the answer?
Cancer Medicine, 2013 Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli +2 more
doaj +1 more source