Results 21 to 30 of about 518,198 (339)

Multiple cutaneous melanomas associated with gastric and brain metastases [PDF]

Anais Brasileiros de Dermatologia, 2016
The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases.
Lara Caroline Grander, Fernanda Cabral, Alice Paixão Lisboa, Gabrielle Vale, Carlos Baptista Barcaui, Juan Manuel Pineiro Maceira   +5 more
doaj   +1 more source

Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]

, 2003
Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A., Eppenberger, H. M., Magyar, J. P., Wagner, E., Weikert, C., Wightman, L.   +5 more
core   +1 more source

Palbociclib in breast cancer neoadjuvant setting

Autopsy and Case Reports, 2021
Cyclin-dependent kinase 4/6 inhibitors represent a major advance in breast cancer treatment, emerging as the standard of care of the initial treatment of hormone receptor-positive and HER2-negative metastatic breast cancer.
Sílvia Alexandra Cabral Duarte, Daniela Silva Pádua de Azevedo, Teresa Tomé Ribeiro Malheiro Sarmento, Marta Verónica Velho Sousa   +3 more
doaj  

The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer [PDF]

, 2012
Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients.
A Bali, C Beretta, D P Lovell, E Papacharalbous, E Rosenberg, G D’Andrilli, H M Coley, HM Coley, I-S Song, K Madhuri, MA Levesque, N A M Safuwan, N Syed, N Syed, P Chivers, P Vlachos, P Zhang, PS Larson, RM Glasspool, S Butler-Manuel, SH Wei, ST Kim, T Crook, T Giannopoulos, T Kobatake, V Masciullo, W Roeb, Y Ma   +27 more
core   +1 more source

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

Journal of Medicinal Chemistry, 2016
Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly 2 decades due to their widely varied and critical functions within the cell.
Yogesh A Sonawane, Margaret A. Taylor, J. V. Napoleon, Sandeep Rana, Jacob I. Contreras, A. Natarajan   +5 more
semanticscholar   +1 more source

Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells

Tumor Biology, 2018
Objectives: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation.
Girolamo Spagnoletti, Valeria Li Bergolis, Annamaria Piscazzi, Francesca Giannelli, Valentina Condelli, Lorenza Sisinni, Giuseppe Bove, Giovanni Storto, Matteo Landriscina   +8 more
doaj   +1 more source

Interaction between Yeast Cdc6 Protein and B-Type Cyclin/Cdc28 Kinases [PDF]

, 1996
During purification of recombinant Cdc6 expressed in yeast, we found that Cdc6 interacts with the critical cell cycle, cyclin-dependent protein kinase Cdc28.
Campbell, Judith L., Elsasser, Suzanne, Jong, Ambrose, Lou, Feng, Wang, Bin   +4 more
core   +1 more source

The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain

Viruses, 2015
Replication of human cytomegalovirus (HCMV) is characterized by a tight virus-host cell interaction. Cyclin-dependent protein kinases (CDKs) are functionally integrated into viral gene expression and protein modification.
Mirjam Steingruber, Eileen Socher, Corina Hutterer, Rike Webel, Tim Bergbrede, Tihana Lenac, Heinrich Sticht, Manfred Marschall   +7 more
doaj   +1 more source

Complexity in cancer biology: is systems biology the answer?

Cancer Medicine, 2013
Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli, Athanasios G. Papavassiliou, Nikolaos A. Papanikolaou   +2 more
doaj   +1 more source

Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing

Laboratory Animal Research, 2018
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers.
Bo Min Park, Jae-il Roh, Jaehoon Lee, Han-Woong Lee   +3 more
doaj   +1 more source