The Cyclin-dependent kinase 1: more than a cell cycle regulator. [PDF]
Br J Cancer, 2023 The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade.
Massacci G, Perfetto L, Sacco F.
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Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors. [PDF]
Med Oncol, 2022 Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in
Sofi S +6 more
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An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1). [PDF]
Cancers (Basel), 2022 Simple Summary Cyclin-dependent kinase 1 (CDK1), one of the key regulators of the G2/M checkpoint, is expressed in many cells and plays an important role in cell cycle control. However, CDK1 expression is substantially increased in many tumors of diverse
Liu X, Wu H, Liu Z.
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Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase [PDF]
Cells, 2020 Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are ...
Jaroslav Kalous +2 more
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Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. [PDF]
J Biol Chem, 2021 Gough RE +11 more
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Cyclin-dependent kinase 1 activity coordinates the chromatin associated state of Oct4 during cell cycle in embryonic stem cells. [PDF]
Nucleic Acids Res, 2018 Cyclin-dependent kinase 1 (Cdk1) is indispensable for embryonic stem cell (ESC) maintenance and embryo development. Even though some reports have described a connection between Cdk1 and Oct4, there is no evidence that Cdk1 activity is directly linked to ...
Kim HJ +10 more
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Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC). [PDF]
Cancers (Basel), 2021 Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in humans, due to late diagnosis and limited treatment possibilities. Improved treatment for PDAC patients is warranted.
Wijnen R +7 more
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Design, Synthesis, and Activity Assays of Cyclin-Dependent Kinase 1 Inhibitors With Flavone Scaffolds [PDF]
Frontiers in Chemistry, 2022 Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of ...
Lanlan Fu +4 more
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Cyclin‐dependent kinase 1 shows to be a potential genetic target for chemical cystitis [PDF]
Immunity, Inflammation and Disease, 2021 Background In the present study, we aimed to explore whether common genetic targets or signaling pathways existed in chemical cystitis. Methods Gene Expression Omnibus (GEO) database was used to search the related gene expression profiles.
Kun Wang +5 more
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Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance [PDF]
FEBS Open Bio, 2021 Cyclin‐dependent kinase 1 (CDK1) plays a significant role in certain malignancies. However, it remains unclear whether CDK1 plays a role in esophageal squamous cell carcinoma (ESCC).
Han‐Jie Zhang +8 more
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