Results 1 to 10 of about 805,965 (369)
Cyclin-dependent kinase 1 shows to be a potential genetic target for chemical cystitis. [PDF]
Immun Inflamm Dis, 2021 AbstractBackgroundIn the present study, we aimed to explore whether common genetic targets or signaling pathways existed in chemical cystitis.MethodsGene Expression Omnibus (GEO) database was used to search the related gene expression profiles. The differentially expressed genes (DEGs) were identified by using GEO2R.
Wang K +5 more
europepmc +5 more sources
Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase. [PDF]
Cells, 2020 Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are essential for cell proliferation and survival.
Kalous J, Jansová D, Šušor A.
europepmc +6 more sources
The Cyclin-dependent kinase 1: more than a cell cycle regulator. [PDF]
Br J Cancer, 2023 AbstractThe Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many ...
Massacci G, Perfetto L, Sacco F.
europepmc +6 more sources
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. [PDF]
J Biol Chem, 2021 AbstractTalin is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behaviour of its multiple rod domains that modulate interactions with its binding partners.
Gough RE +11 more
europepmc +10 more sources
An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1). [PDF]
Cancers (Basel), 2022 Cyclin-dependent kinase 1 (CDK1) is essential for cell division by regulating the G2/M phase and mitosis. CDK1 overexpression can also promote the development and progression of a variety of cancers. However, the significance of CDK1 in the formation, progression, and prognosis of human pan-cancer remains unclear.
Liu X, Wu H, Liu Z.
europepmc +3 more sources
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses [PDF]
Proceedings of the National Academy of Sciences, 2004 Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in resting synapses and stimulation ...
Sang Yoon Lee +4 more
openaire +4 more sources
Cyclin dependent kinase 1-dependent activation of APC/C ubiquitin ligase [PDF]
Science, 2016 Error-free genome duplication and segregation are ensured through the timely activation of ubiquitylation enzymes. The anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, is regulated by phosphorylation.
Fujimitsu, K, Grimaldi, M, Yamano, H
core +6 more sources
The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development. [PDF]
Sci Rep, 2016 AbstractSkeletal development is tightly regulated through the processes of chondrocyte proliferation and differentiation. Although the involvement of transcription and growth factors on the regulation of skeletal development has been extensively studied, the role of cell cycle regulatory proteins in this process remains elusive.
Saito M +6 more
europepmc +4 more sources
Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation. [PDF]
Oncotarget, 2016 The multifunctional protein p21Cip1/CDKN1A (p21) is an important and universal Cdk-interacting protein. Recently, we have reported that p21 is involved in the regulation of the mitotic kinase Cdk1/cyclin B1 and critical for successful mitosis and cytokinesis.
Kreis NN +7 more
europepmc +7 more sources
Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases. [PDF]
Proceedings of the National Academy of Sciences, 1994 Protein phosphatase 1 and protein phosphatase 2A contain potential phosphorylation sites for cyclin-dependent kinases. In the present study we found that rabbit skeletal muscle protein phosphatase 1, as well as recombinant protein phosphatase 1 alpha and protein phosphatase 1 gamma 1, but not protein phosphatase 2A, was phosphorylated and inhibited by ...
E F da Cruz e Silva +7 more
openaire +3 more sources