Cyclin dependent kinase 1-dependent activation of APC/C ubiquitin ligase [PDF]
Science, 2016 Error-free genome duplication and segregation are ensured through the timely activation of ubiquitylation enzymes. The anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, is regulated by phosphorylation.
Fujimitsu, K, Grimaldi, M, Yamano, H
core +6 more sources
Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation. [PDF]
Oncotarget, 2016 The multifunctional protein p21Cip1/CDKN1A (p21) is an important and universal Cdk-interacting protein. Recently, we have reported that p21 is involved in the regulation of the mitotic kinase Cdk1/cyclin B1 and critical for successful mitosis and ...
Kreis NN +7 more
europepmc +7 more sources
The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development. [PDF]
Sci Rep, 2016 Skeletal development is tightly regulated through the processes of chondrocyte proliferation and differentiation. Although the involvement of transcription and growth factors on the regulation of skeletal development has been extensively studied, the ...
Saito M +6 more
europepmc +5 more sources
Tumor Biology, 2018 Objectives: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation.
Girolamo Spagnoletti +8 more
doaj +2 more sources
MicroRNA‑424 serves an anti‑oncogenic role by targeting cyclin‑dependent kinase 1 in breast cancer cells. [PDF]
Oncol Rep, 2018 The aim of the present study was to define the function of microRNA-424-5p (miR-424) in breast cancer cells. The present study investigated the level and the potential function of miR-424 in breast cancer by reverse transcription-quantitative polymerase ...
Xie D +11 more
europepmc +2 more sources
Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation [PDF]
Cell Research, 2009 Cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complex is the driving force for mitotic entry, and its activation is tightly regulated by the G2/M checkpoint. We originally reported that a novel protein C53 (also known as Cdk5rap3 and LZAP) potentiates DNA damage-induced cell death by modulating the G2/M checkpoint. More recently, Wang et al.
Hai Jiang +4 more
semanticscholar +4 more sources
Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor. [PDF]
PLoS Biology, 2021 Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division.
Christina D Cota +5 more
doaj +2 more sources
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics. [PDF]
Mol Cell Proteomics, 2016 Cyclin-dependent kinase 1 (Cdk1) is an essential regulator of many mitotic processes including the reorganization of the cytoskeleton, chromosome segregation, and formation and separation of daughter cells. Deregulation of Cdk1 activity results in severe
Petrone A +3 more
europepmc +2 more sources
First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation
Journal of Cell Science, 2019 During mitosis, anaphase is triggered by anaphase-promoting complex (APC)-mediated destruction of securin and cyclin B1, which leads to inactivation of cyclin-dependent kinase 1 (Cdk1). By regulating APC activity, the mitotic spindle assembly checkpoint (
Chenxi Zhou +3 more
semanticscholar +4 more sources
Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy [PDF]
Frontiers in Cell and Developmental Biology, 2020 Satellite cell proliferation is an essential step in proper skeletal muscle development and muscle regeneration. However, the mechanisms regulating satellite cell proliferation are relatively unknown compared to the knowledge associated with the ...
Yutaka Kobayashi +8 more
doaj +2 more sources