Results 11 to 20 of about 805,965 (369)

Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells. [PDF]

Tumor Biology, 2018
Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation.
Bove, Giuseppe, Condelli, Valentina, Giannelli, Francesca, Landriscina, Matteo, Li Bergolis, Valeria, Piscazzi, Annamaria, Sisinni, Lorenza, Spagnoletti, Girolamo, Storto, Giovanni   +8 more
core   +2 more sources

HIV-1 expression induces cyclin D(1) expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy [PDF]

BMC Microbiology, 2002
BACKGROUND: The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium
Gelman, Irwin H, Husain, Mohammad, Nelson, Peter J, Sunamoto, Masaaki   +3 more
core   +5 more sources

Regulation of Protein Phosphatase Inhibitor-1 by Cyclin-dependent Kinase 5 [PDF]

Journal of Biological Chemistry, 2007
Inhibitor-1, the first identified endogenous inhibitor of protein phosphatase 1 (PP-1), was previously reported to be a substrate for cyclin-dependent kinase 5 (Cdk5) at Ser67. Further investigation has revealed the presence of an additional Cdk5 site identified by mass spectrometry and confirmed by site-directed mutagenesis as Ser6.
Angus C. Nairn, Angus C. Nairn, Akinori Nishi, Hugh C. Hemmings, Janice W. Kansy, Frank Gillardon, Joseph Fernandez, James A. Bibb, Kanehiro Hayashi, Chan Nguyen   +9 more
openaire   +5 more sources

t‐Darpp is an elongated monomer that binds calcium and is phosphorylated by cyclin‐dependent kinases 1 and 5 [PDF]

FEBS Open Bio, 2017
t‐Darpp (truncated isoform of dopamine‐ and cAMP‐regulated phosphoprotein) is a protein encoded by the PPP1R1B gene and is expressed in breast, colon, esophageal, gastric, and prostate cancers, as well as in normal adult brain striatal cells. Overexpression of t‐Darpp in cultured cells leads to increased protein kinase A activity and increased ...
Momand, Jamil, Magdziarz, Patrycja, Feng, You, Jiang, Dianlu, Parga, Elizabeth, Celis, Arianna, Denny, Erin, Wang, Xiaoying, Phillips, Martin L., Monterroso, Estuardo, Kane, Susan E., Zhou, Feimeng   +11 more
openaire   +5 more sources

Inhibitory Phosphorylation of Cyclin-Dependent Kinase 1 as a Compensatory Mechanism for Mitosis Exit [PDF]

Molecular and Cellular Biology, 2011
The current paradigm states that exit from mitosis is triggered by the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) acting in concert with an activator called CDC20. While this has been well established for a number of systems, the evidence of a critical role of CDC20 in somatic cells is not unequivocal.
Chow, Jeremy Pak Hong, Poon, Randy Yat Choi, Ma, Hoi Tang   +2 more
openaire   +4 more sources

Design, Synthesis, and Activity Assays of Cyclin-Dependent Kinase 1 Inhibitors With Flavone Scaffolds. [PDF]

Front Chem, 2022
Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of ...
Fu L, Mou J, Deng Y, Ren X, Qiu S.
europepmc   +2 more sources

Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1 [PDF]

Journal of Clinical Investigation, 2012
Altered lipid metabolism underlies several major human diseases, including obesity and type 2 diabetes. However, lipid metabolism pathophysiology remains poorly understood at the molecular level. Insulin is the primary stimulator of hepatic lipogenesis through activation of the SREBP-1c transcription factor. Here we identified cyclin-dependent kinase 8
Yan Sun, Lauren Bridges, Fajun Yang, Jie Zhou, Jie Zhou, Chenguang Wang, Ellen S. Yang, Johan Ericsson, Lu Ping Liu, Irwin J. Kurland, Jeffrey E. Pessin, Xiao-Jun Xie, Randy Strich, Qun Wang, Bhavapriya Vaitheesvaran, Arian Abdulla, Daorong Feng, Xiaoping Zhao, Jun-Yuan Ji, Jian-Quan Ni   +19 more
openaire   +4 more sources

Overexpression of cyclin-dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance. [PDF]

FEBS Open Bio, 2021
Cyclin‐dependent kinase 1 (CDK1) plays a significant role in certain malignancies. However, it remains unclear whether CDK1 plays a role in esophageal squamous cell carcinoma (ESCC).
Zhang HJ, Chen G, Chen SW, Fu ZW, Zhou HF, Feng ZB, Mo JX, Li CB, Liu J.   +8 more
europepmc   +2 more sources

Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor. [PDF]

PLoS Biol, 2021
Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division.
Cota CD, Dreier MS, Colgan W, Cha A, Sia T, Davidson B.   +5 more
europepmc   +2 more sources

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis

Cells, 2023
The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj   +1 more source