Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences [PDF]
, 2002 The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1.
Bourgeois, Cyril F +4 more
core +3 more sources
Cyclin-dependent kinases as therapeutic targets for HIV-1 infection [PDF]
Expert Opinion on Therapeutic Targets, 2016 A number of cyclin-dependent kinases (CDKs) mediate key steps in the HIV-1 replication cycle and therefore have potential to serve as therapeutic targets for HIV-1 infection, especially in HIV-1 cure strategies. Current HIV-1 cure strategies involve the development of small molecules that are able to activate HIV-1 from latent infection, thereby ...
openaire +3 more sources
CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. [PDF]
PLoS ONE, 2011 C-C chemokine receptor 7 (CCR7) contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC) cells remains vague. Proliferation assays performed on A549 and H460 NSCLC cells using
Ying Xu +8 more
doaj +1 more source
Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]
, 2014 Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Amalie E. Dick +36 more
core +1 more source
Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors [PDF]
Proceedings of the National Academy of Sciences, 2001 Cyclin-dependent kinase 5 (Cdk5) is a multifunctional neuronal protein kinase that is required for neurite outgrowth and cortical lamination and that plays an important role in dopaminergic signaling in the neostriatum through phosphorylation of Thr-75 of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, molecular mass 32 kDa ...
Anthony J. Demaggio +8 more
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Herpes Simplex Virus Type 1 Infection Imposes a G1/S Block in Asynchronously Growing Cells and Prevents G1 Entry in Quiescent Cells [PDF]
, 2000 Herpes simplex virus type 1 (HSV-1) infection disrupted cell cycle regulation in at least two ways. First, infection of quiescent human embryonic lung cells simultaneously with readdition of serum caused inhibition of cyclin D/cyclin-dependent kinase ...
Bachenheimer, Steven L. +2 more
core +2 more sources
Cyclin-Dependent Kinase 16/PCTAIRE Kinase 1 Is Activated by Cyclin Y and Is Essential for Spermatogenesis [PDF]
Molecular and Cellular Biology, 2012 Cyclin-dependent kinase 16 (CDK16, PCTK1) is a poorly characterized protein kinase, highly expressed in the testis and the brain. Here, we report that CDK16 is activated by membrane-associated cyclin Y (CCNY). Treatment of transfected human cells with the protein kinase A (PKA) activator forskolin blocked, while kinase inhibition promoted, CCNY ...
Petra Mikolcevic +8 more
openaire +5 more sources
Taiwanese Journal of Obstetrics & Gynecology, 2016 Objective: Carfilzomib is a second-generation tetrapeptide epoxyketone proteasome inhibitor used in current clinical therapy of hematologic malignancies. The mechanism of proteasome inhibition in endometrial cancer is not very clear.
Yuanyuan Zhou +4 more
doaj +1 more source
Effect of ECT2 Gene on Proliferation of Cervical Cancer Cells and Its Mechanism
Zhongliu Fangzhi Yanjiu, 2022 Objective To study the effect of epithelial cell transformation sequence 2 (ECT2) on the proliferation of cervical cancer cells and its mechanism. Methods We transfected cervical cancer cells HeLa (HeLa-ECT2) with the lentivirus overexpressing ECT2 and ...
CHEN Yu +3 more
doaj +1 more source
The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription [PDF]
, 2009 Epithelial tight junctions recruit different types of signalling proteins that regulate cell proliferation and differentiation. Little is known about how such proteins interact functionally and biochemically with each other.
Aijaz, S. +4 more
core +2 more sources