Results 51 to 60 of about 384,579 (349)
Taiwanese Journal of Obstetrics & Gynecology, 2016 Objective: Carfilzomib is a second-generation tetrapeptide epoxyketone proteasome inhibitor used in current clinical therapy of hematologic malignancies. The mechanism of proteasome inhibition in endometrial cancer is not very clear.
Yuanyuan Zhou +4 more
doaj +1 more source
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
core +1 more source
Regulation of Protein Phosphatase Inhibitor-1 by Cyclin-dependent Kinase 5 [PDF]
Journal of Biological Chemistry, 2007 Inhibitor-1, the first identified endogenous inhibitor of protein phosphatase 1 (PP-1), was previously reported to be a substrate for cyclin-dependent kinase 5 (Cdk5) at Ser67. Further investigation has revealed the presence of an additional Cdk5 site identified by mass spectrometry and confirmed by site-directed mutagenesis as Ser6.
Chan, Nguyen +8 more
openaire +2 more sources
Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
Scientific Reports, 2023 p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs.
Rhianna J. Rowland +8 more
doaj +1 more source
Effect of ECT2 Gene on Proliferation of Cervical Cancer Cells and Its Mechanism
Zhongliu Fangzhi Yanjiu, 2022 Objective To study the effect of epithelial cell transformation sequence 2 (ECT2) on the proliferation of cervical cancer cells and its mechanism. Methods We transfected cervical cancer cells HeLa (HeLa-ECT2) with the lentivirus overexpressing ECT2 and ...
CHEN Yu +3 more
doaj +1 more source
Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]
, 2014 We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura +10 more
core +1 more source
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses [PDF]
Proceedings of the National Academy of Sciences, 2004 Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in resting synapses and stimulation ...
Sang Yoon, Lee +4 more
openaire +2 more sources
Molecules, 2020 As a plant medicine, Oxalidaceae has been used to treat various diseases in Korea. However, there is little data on the anti-cancer efficacy of Oxalidaceae, particularly O. obtriangulata.
Eun-Jin An +5 more
doaj +1 more source
Scientific Reports, 2021 S-phase kinase associated protein 2 (Skp2), a member of the F-box family that constitute the largest known class of ubiquitin E3 specificity components, is responsible for recognizing and recruiting cyclin-dependent kinase inhibitor p27 for its ...
Kaizhao Hu +4 more
doaj +1 more source
Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [PDF]
, 2009 Background. In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner.
Aikaterini Bilitou +6 more
core +3 more sources