Results 51 to 60 of about 805,965 (369)
Molecules, 2020 As a plant medicine, Oxalidaceae has been used to treat various diseases in Korea. However, there is little data on the anti-cancer efficacy of Oxalidaceae, particularly O. obtriangulata.
Eun-Jin An +5 more
doaj +1 more source
Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
Scientific Reports, 2023 p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs.
Rhianna J. Rowland +8 more
doaj +1 more source
Quantification of noise in the bifunctionality-induced post-translational modification [PDF]
Phys Rev E 88 (2013) 032716, 2012 We present a generic analytical scheme for the quantification of fluctuations due to bifunctionality-induced signal transduction within the members of bacterial two-component system. The proposed model takes into account post-translational modifications in terms of elementary phosphotransfer kinetics. Sources of fluctuations due to autophosphorylation,
arxiv +1 more source
Scientific Reports, 2021 S-phase kinase associated protein 2 (Skp2), a member of the F-box family that constitute the largest known class of ubiquitin E3 specificity components, is responsible for recognizing and recruiting cyclin-dependent kinase inhibitor p27 for its ...
Kaizhao Hu +4 more
doaj +1 more source
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
core +1 more source
Acta Pharmaceutica Sinica B, 2022 Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this ...
Sha-Sha Cheng +12 more
doaj
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]
PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008 Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv +1 more source
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]
, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C. +2 more
core +2 more sources
AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9 [PDF]
Cancer Research, 2006 Abstract Preclinical studies were performed of a novel selective imidazopyridine cyclin-dependent kinase (cdk) inhibitor, AZ703. In vitro kinase assays showed that IC50 values for AZ703 against purified cyclin E/cdk2 and cyclin B/cdk1 were 34 and 29 nmol/L, respectively. In contrast, the IC50 against cdk4 was >10 μmol/L.
Dongpo Cai +2 more
openaire +3 more sources
Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways. [PDF]
PLoS ONE, 2018 The present study was designed to investigate the pathways involved in the effect of betel nut arecoline on cell viability in 3T3-L1 preadipocytes. Arecoline, but not arecaidine or guvacine, inhibited preadipocyte viability in a concentration- and time ...
Zi-Han Tian +8 more
doaj +1 more source