Results 21 to 30 of about 338,209 (343)
Cyclin-dependent Kinase 5 Promotes Insulin Exocytosis [PDF]
Journal of Biological Chemistry, 2001 Cyclin-dependent kinase 5 (Cdk5) is widely expressed although kinase activity has been described preferentially in neuronal systems. Cdk5 has an impact on actin polymerization during neuronal migration and neurite outgrowth and deregulation of the kinase has been implicated in the promotion of neurodegeneration.
L, Lilja +5 more
openaire +2 more sources
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy
Biomédica: revista del Instituto Nacional de Salud, 2018 Introduction: Cerebral ischemia is the third cause of death risk in Colombia and the first cause of physical disability worldwide. Different studies on the silencing of the cyclin-dependent kinase 5 (CDK5) have shown that reducing its activity is ...
Juan Ignacio Muñoz-Manco +2 more
doaj +1 more source
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]
, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C. +2 more
core +2 more sources
Journal of Neuroinflammation, 2018 Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis.
A. Wilkaniec +4 more
semanticscholar +1 more source
CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors
Biomolecules, 2022 In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the ...
Joana Guiro +6 more
doaj +1 more source
Cyclin-dependent kinase 5 activity regulates pain signaling [PDF]
Proceedings of the National Academy of Sciences, 2006 Several molecules and cellular pathways have been implicated in nociceptive signaling, but their precise molecular mechanisms have not been clearly defined. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system.
Tej K, Pareek +6 more
openaire +2 more sources
Antioxidants, 2023 The DNA glycosylase NEIL2 plays a central role in maintaining genome integrity, in particular during oxidative stress, by recognizing oxidized base lesions and initiating repair of these via the base excision repair (BER) pathway.
Camilla Myrup Holst +6 more
doaj +1 more source
The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes [PDF]
, 2005 Exit from the mitotic cell cycle and initiation of cell differentiation frequently coincides with the onset of endoreduplication, a modified cell cycle during which DNA continues to be duplicated in the absence of mitosis. Although the mitotic cell cycle
Verkest, Aurine +9 more
core +1 more source
Frontiers in Pharmacology, 2023 Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring.
Yuxiao Wan +3 more
doaj +1 more source
Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1 [PDF]
, 2016 BACKGROUND: Modulation of protein activity by phosphorylation through kinases and subsequent de-phosphorylation by phosphatases is one of the most prominent cellular control mechanisms.
Dissmeyer, N. +6 more
core +2 more sources