Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids
Neurobiology of Disease, 2023 Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that has emerged as a key regulator of neurotransmission in complex cognitive processes. Its expression is altered in treated schizophrenia patients, and cannabinoids modulate CDK5 levels in ...
Marta Barrera-Conde +10 more
doaj +1 more source
Cyclin-dependent kinase 5 activity regulates pain signaling [PDF]
Proceedings of the National Academy of Sciences, 2006 Several molecules and cellular pathways have been implicated in nociceptive signaling, but their precise molecular mechanisms have not been clearly defined. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system.
Tej K, Pareek +6 more
openaire +2 more sources
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
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Cyclin-Dependent Kinase 5 Is Required for Associative Learning [PDF]
The Journal of Neuroscience, 2002 Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress.
Fischer, A. +4 more
openaire +4 more sources
A kinase of many talents: non-neuronal functions of CDK5 in development and disease [PDF]
Open Biology, 2020 The cyclin-dependent kinase 5 (CDK5) represents an unusual member of the family of cyclin-dependent kinases, which is activated upon binding to non-cyclin p35 and p39 proteins. The role of CDK5 in the nervous system has been very well established.
Samanta Sharma, Piotr Sicinski
doaj +1 more source
Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]
, 2011 G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core +3 more sources
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. [PDF]
, 2011 Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual ...
Balog, Eva Rose M +8 more
core +2 more sources
Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
PLoS ONE, 2009 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.
Ammar H Hawasli +7 more
doaj +1 more source
Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]
, 2014 We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura +10 more
core +1 more source
Tumor Biology, 2018 Objectives: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation.
Girolamo Spagnoletti +8 more
doaj +1 more source