Results 1 to 10 of about 29,666 (204)

Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. [PDF]

PLoS ONE, 2011
Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are ...
Josette M Douville, David Y C Cheung, Krista L Herbert, Teri Moffatt, Jeffrey T Wigle   +4 more
doaj   +3 more sources

Protective Effect of Multifloral Honey on Stem Cell Aging in a Dynamic Cell Culture Model [PDF]

Antioxidants
Natural compounds, as honey-derived flavonoids and phenolic compounds, are increasingly investigated for their potential to mitigate skin aging and prevent oxidative stress-induced cellular damages.
Fikriye Fulya Kavak, Sara Cruciani, Giuseppe Garroni, Diletta Serra, Rosanna Satta, Ibrahim Pirim, Melek Pehlivan, Margherita Maioli   +7 more
doaj   +2 more sources

Fermented Porcine Placenta and Its Dipeptides Modulate Cellular Senescence in Human Keratinocytes [PDF]

Current Issues in Molecular Biology
Skin aging is primarily driven by oxidative stress, mitochondrial dysfunction, and cell cycle dysregulation. This study investigated the anti-senescence effects of fermented porcine placenta (FPP) and its dipeptides, leucine–glycine (LG) and proline ...
Yea Jung Choi, Minseo Kang, Mu Hyun Jin, Jongbae Kim, Won Kyung Lee, Seok-Seon Roh, Ki Sung Kang, Gwi Seo Hwang, Sangki Park, Sullim Lee   +9 more
doaj   +2 more sources

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice [PDF]

Advanced Science
Aging is marked by the accumulation of cells expressing the cyclin‐dependent kinase inhibitor p16Ink4a. These p16⁺ cells, largely senescent, contribute to inflammation and tissue dysfunction. While eliminating p16⁺ cells improves healthspan, sex‐specific
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
doaj   +2 more sources

CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen [PDF]

npj Breast Cancer
Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor–positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer.
Nealia C. House, Maxine M. Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H. Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A. Bristow, Timothy A. Yap, Khandan Keyomarsi, Joseph R. Marszalek, Scott Ribich, Mikael L. Rinne, Lakshmi B. Muthuswamy, Kerrie L. Faia   +19 more
doaj   +2 more sources

Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma

Pathology - Research and Practice, 2021
Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (
Sofija Glumac, Radoslav Davidovic, Branko Dozic, Sasa Hinic, Ivan Pavlovic, Dunja Drakulic, Ana Todorović, Maja Medojevic Pavlovic, Sanja Radojevic Skodric, Ivana Baralic, Jelena Sopta, Snezana Pejic   +11 more
openaire   +3 more sources

Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias [PDF]

Blood, 1994
Abstract Recently, it has been shown that the homozygous deletion of the cyclin- dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-suppressor gene.
S, Ogawa, N, Hirano, N, Sato, T, Takahashi, A, Hangaishi, K, Tanaka, M, Kurokawa, T, Tanaka, K, Mitani, Y, Yazaki   +9 more
openaire   +5 more sources

P16 expression in human breast carcinoma and its relationship to clinicopathological parameters

Advanced Biomedical Research, 2023
Background: p16 is a cyclin-dependent kinase inhibitor and a cardinal regulator of the cell cycle. The relationship between p16 overexpression and poor prognosis of breast cancer has been reported in some studies.
Fereshteh Mohammadizadeh, Farnaz Nasri
doaj   +1 more source

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. [PDF]

, 2014
Understanding genetic aberrations in cancer leads to discovery of new targets for cancer therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully described. Therefore, patients with refractory advanced/metastatic HCC referred
Janku, Filip, Kaseb, Ahmed O, Kurzrock, Razelle, Tsimberidou, Apostolia M, Wolff, Robert A   +4 more
core   +9 more sources

Expression of the cyclin‐dependent kinase inhibitor p16 during the ongoing cell cycle [PDF]

FEBS Letters, 1995
It has been demonstrated that protein expression of p16, the inhibitor of cyclin‐dependent kinase 4 and 6, increases 4 fold at the G1/S transition when serum‐arrested cells are restimulated to logarithmic growth. We examined the cell cycle regulation of this cyclin‐dependent kinase inhibitor in cells separated according to their cell cycle phases by ...
Soucek, Thomas, Pusch, Oliver, Hengstschläger-Ottnad, Elke, Wawra, Edgar, Bernaschek, Gerhard, Hengstschläger, Markus   +5 more
openaire   +2 more sources