Results 21 to 30 of about 18,481 (166)
Haematologica, 2017 P27Kip1 (p27) can prevent cell proliferation by inactivating cyclin-dependent kinases. This function is impaired upon phosphorylation of p27 at tyrosine residue 88. We observed that FLT3 and FLT3-ITD can directly bind and selectively phosphorylate p27 on
Ines Peschel +8 more
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Expression of cyclin-dependent kinase inhibitor p27kip1in malignant lymphomas [PDF]
Journal of Korean Medical Science, 2000 p27kip1 is a cyclin-dependent kinase inhibitor that regulates progression from G1 into S phase. Aberrations in cell cycle control are often observed in tumors and might even be necessary in tumor development. Recent reports showed that low p27kip1 expression is associated with poor prognosis in several tumors and leukemia. To investigate the expression
Y H, Oh, C K, Park
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PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27Kip1 [PDF]
Nucleic Acids Research, 2012 P27(Kip1) (p27) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Recently, a new function of p27 as transcriptional regulator has been reported. It has been shown that p27 regulates the expression of target genes mostly involved in splicing, cell cycle, respiration and translation.
Pérez-Luna, Maria +6 more
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Cancer Cell International, 2006 Background p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventive anti-cancer agents up-regulate ...
Eto Isao
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p27kip1: a target for tumor therapies?
Cell Division, 2007 The cyclin kinase inhibitor p27kip1 acts as a potent tumor supressor protein in a variety of human cancers. Its expression levels correlate closely with the overall prognosis of the affected patient and often predict the outcome to different treatment ...
Kossatz Uta +3 more
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BMC Cell Biology, 2002 Background The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased ...
Schulz Holger, Lu Lifang, Wolf Dieter A
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Pharmaceutics, 2021 Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are propagated toward uncontrolled cell division and proliferation in ...
Dharambir Kashyap +4 more
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Cell Death and Disease, 2021 The cyclin-dependent kinase inhibitor p27Kip1 (p27) has been involved in promoting autophagy and survival in conditions of metabolic stress. While the signaling cascade upstream of p27 leading to its cytoplasmic localization and autophagy induction has ...
Ada Nowosad +7 more
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The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma. [PDF]
PLoS ONE, 2012 GNAQ mutations at codon 209 have been recently identified in approximately 50% of uveal melanomas (UM) and are reported to be oncogenic through activating the MAPK/Erk1/2 pathway.
Xinqi Wu +4 more
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مجلة كلية الطبBackground: Cell-cycle-regulating proteins, including cyclin-dependent kinase inhibitor 1B p27kip1, have been researched in different malignancies, including thyroid carcinoma, and their association with tumor aggressiveness and recurrence has been ...
Wafaa K. Ibrahim, khitam R. Al-khafaji
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