A review on the role of cyclin dependent kinases in cancers [PDF]
Cancer Cell International, 2022 The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
Soudeh Ghafouri-Fard +7 more
doaj +3 more sources
Cyclin-dependent kinases [PDF]
Genome Biology, 2014 Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity.
Marcos Malumbres
semanticscholar +4 more sources
Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases [PDF]
Pharmaceuticals, 2023 Cyclin-dependent kinases (CDKs) play diverse and critical roles in normal cells and may be exploited as targets in cancer therapeutic strategies. CDK4 inhibitors are currently approved for treatment in advanced breast cancer.
Mark Klein
doaj +2 more sources
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review. [PDF]
Int J Mol Sci, 2021 Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis.
Łukasik P, Załuski M, Gutowska I.
europepmc +2 more sources
Cyclin-dependent kinases and rare developmental disorders [PDF]
Orphanet Journal of Rare Diseases, 2020 Extensive studies in the past 30 years have established that cyclin-dependent kinases (CDKs) exert many diverse, important functions in a number of molecular and cellular processes that are at play during development.
Pierre Colas
doaj +2 more sources
Cyclin-dependent kinases in
Cell Division, 2006 Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth.
Boxem Mike
doaj +4 more sources
Gene expression profiles of skin from cyclin dependent kinases 5-knockdown mice [PDF]
Animal BioscienceObjective This study aimed to identify genes regulated by cyclin dependent kinases 5 (CDK5) that participate in hair pigmentation in mice. Methods The mRNA expression profiles of skin samples from CDK5-knockdown mice were constructed using high ...
Shanshan Yang +5 more
doaj +2 more sources
Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma [PDF]
BMC Gastroenterology, 2022 Background Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene.
Zhong-liu Wei +7 more
doaj +2 more sources
Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology [PDF]
Scientific Reports, 2022 Transcriptional addiction is recognized as a valid therapeutic target in cancer, whereby the dependency of cancer cells on oncogenic transcriptional regulators may be pharmacologically exploited.
Micah G. Donovan +2 more
doaj +2 more sources
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
Nature Communications, 2019 Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis.
Astrid Weiss +15 more
doaj +2 more sources