Results 1 to 10 of about 88,246 (137)
A review on the role of cyclin dependent kinases in cancers [PDF]
Cancer Cell International, 2022 The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
Soudeh Ghafouri-Fard +7 more
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Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases [PDF]
Pharmaceuticals, 2023 Cyclin-dependent kinases (CDKs) play diverse and critical roles in normal cells and may be exploited as targets in cancer therapeutic strategies. CDK4 inhibitors are currently approved for treatment in advanced breast cancer.
Mark Klein
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Cyclin-dependent kinases and rare developmental disorders [PDF]
Orphanet Journal of Rare Diseases, 2020 Extensive studies in the past 30 years have established that cyclin-dependent kinases (CDKs) exert many diverse, important functions in a number of molecular and cellular processes that are at play during development.
Pierre Colas
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Gene expression profiles of skin from cyclin dependent kinases 5-knockdown mice [PDF]
Animal BioscienceObjective This study aimed to identify genes regulated by cyclin dependent kinases 5 (CDK5) that participate in hair pigmentation in mice. Methods The mRNA expression profiles of skin samples from CDK5-knockdown mice were constructed using high ...
Shanshan Yang +5 more
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Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma [PDF]
BMC Gastroenterology, 2022 Background Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene.
Zhong-liu Wei +7 more
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Cyclin-dependent kinases as mediators of aberrant transcription in prostate cancer [PDF]
Translational OncologyTranscriptional control of gene expression is fundamental to all cellular processes. Conversely, transcriptional dysregulation is a hallmark of cancer.
Razia Rahman, Luke A. Selth
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Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology [PDF]
Scientific Reports, 2022 Transcriptional addiction is recognized as a valid therapeutic target in cancer, whereby the dependency of cancer cells on oncogenic transcriptional regulators may be pharmacologically exploited.
Micah G. Donovan +2 more
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Kouqiang hemian waike zazhi, 2023 Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial cancer. In‐depth research on the regulatory mechanism of cell cycle regulation‐related molecules has revealed that these molecules play various roles in the incidence and ...
HOU Zeyu, TANG Jinru, LI Longjiang
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Multiple cutaneous melanomas associated with gastric and brain metastases [PDF]
Anais Brasileiros de Dermatologia, 2016 The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases.
Lara Caroline Grander +5 more
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Frontiers in Microbiology, 2022 The larval stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans.
Chonglv Feng +13 more
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