A review on the role of cyclin dependent kinases in cancers [PDF]
Cancer Cell International, 2022 The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
Soudeh Ghafouri-Fard +7 more
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Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases [PDF]
Pharmaceuticals, 2023 Cyclin-dependent kinases (CDKs) play diverse and critical roles in normal cells and may be exploited as targets in cancer therapeutic strategies. CDK4 inhibitors are currently approved for treatment in advanced breast cancer.
Mark Klein
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Cyclin-dependent kinases and rare developmental disorders [PDF]
Orphanet Journal of Rare Diseases, 2020 Extensive studies in the past 30 years have established that cyclin-dependent kinases (CDKs) exert many diverse, important functions in a number of molecular and cellular processes that are at play during development.
Pierre Colas
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Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma [PDF]
BMC Gastroenterology, 2022 Background Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene.
Zhong-liu Wei +7 more
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Gene expression profiles of skin from cyclin dependent kinases 5-knockdown mice [PDF]
Animal BioscienceObjective This study aimed to identify genes regulated by cyclin dependent kinases 5 (CDK5) that participate in hair pigmentation in mice. Methods The mRNA expression profiles of skin samples from CDK5-knockdown mice were constructed using high ...
Shanshan Yang +5 more
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Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology [PDF]
Scientific Reports, 2022 Transcriptional addiction is recognized as a valid therapeutic target in cancer, whereby the dependency of cancer cells on oncogenic transcriptional regulators may be pharmacologically exploited.
Micah G. Donovan +2 more
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Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy [PDF]
Acta Pharmaceutica Sinica B, 2021 Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical ...
Kailin Li +7 more
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Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers [PDF]
Infectious Agents and Cancer, 2020 The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor ...
Shaian Tavakolian +2 more
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Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
Multiple cutaneous melanomas associated with gastric and brain metastases [PDF]
Anais Brasileiros de Dermatologia, 2016 The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases.
Lara Caroline Grander +5 more
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