Results 61 to 70 of about 391,733 (291)

Alternate cyclin D1 mRNA splicing modulates P27\u3csup\u3eKlP1\u3c/sup\u3e binding and cell migration [PDF]

, 2008
Cyclin D1 is an important cell cycle regulator but in cancer its overexpression also increases cellular migration mediated by p27KlP1 stabilization and RhoA inhibition.
Casimiro, Mathew C., Jiao, Xuanmao, Katiyar, Sanjay, Li, Zhiping, Pestell, Richard G., Powell, Michael J., Prendergast, George C., Wang, Chenguang   +7 more
core   +1 more source

Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity [PDF]

Journal of Virology, 2012
ABSTRACTAlterations in the functional levels of cyclin-dependent kinase-8 (CDK8) or its partner, cyclin C, have been clearly associated with cancers, including colon cancer, melanoma, and osteosarcoma. Walleye dermal sarcoma virus encodes a retroviral cyclin (RV-cyclin) that localizes to interchromatin granule clusters and binds CDK8.
Joel, Rovnak, Connie D, Brewster, Sandra L, Quackenbush   +2 more
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Inhibition of Mitochondrial Antioxidant Defense and CDK4/6 in Mesothelioma

Molecules, 2023
Advanced mesothelioma is considered an incurable disease and new treatment strategies are needed. Previous studies have demonstrated that mitochondrial antioxidant defense proteins and the cell cycle may contribute to mesothelioma growth, and that the ...
Marian Kratzke, George Scaria, Stephen Porter, Betsy Kren, Mark A. Klein   +4 more
doaj   +1 more source

Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [PDF]

Biochemical and Biophysical Research Communications, 2009
The distinct expression patterns of the two A-type cyclins during spermatogenesis and the absolute requirement for cyclin A1 in this biological process in vivo suggest that they may confer distinct biochemical properties to their CDK partners. We therefore compared human cyclin A1- and cyclin A2-containing CDK complexes in vitro by determining kinetic ...
Ayesha R, Joshi, Vaidehi, Jobanputra, Karen M, Lele, Debra J, Wolgemuth   +3 more
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis

Cells, 2019
Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis.
Meghna Kataria, Hiroyuki Yamano
doaj   +1 more source

Comprehensive Analysis of Cyclin Family Gene Expression in Colon Cancer

Frontiers in Oncology, 2021
Colon cancer is a common malignancy of the digestive tract with high morbidity and mortality. There is an urgent need to identify effective biomarkers for the early diagnosis of colon cancer and to prolong patient survival.
Jieling Li, Liyuan Zhou, Ying Liu, Lingzhi Yang, Dayi Jiang, Kuan Li, Shouxia Xie, Xiao Wang, Shaoxiang Wang   +8 more
doaj   +1 more source

Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]

, 2009
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Atsushi Yoshiki, Hitomi Hasegawa, Jianzhi Pan, Kazunari K. Yokoyama, Koji Nakade, Naoto Yamaguchi, Satoko Masuzaki, Takehide Murata, Yu-Chang Huang, Yuichi Obata   +9 more
core   +1 more source

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source