Results 231 to 240 of about 242,314 (247)
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Plant Molecular Biology, 1996
Cyclins, a large family of proteins, are the regulatory subunits of cyclin-dependent protein kinase that are essential activators of cell cycle progression in eukaryotes. Here we report isolation of a new cyclin cDNA (cyclbAt) from Arabibopsis cDNA libraries using polymerase chain reaction amplified cyclin-box sequences as probes.
I S, Day, A S, Reddy, M, Golovkin
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Cyclins, a large family of proteins, are the regulatory subunits of cyclin-dependent protein kinase that are essential activators of cell cycle progression in eukaryotes. Here we report isolation of a new cyclin cDNA (cyclbAt) from Arabibopsis cDNA libraries using polymerase chain reaction amplified cyclin-box sequences as probes.
I S, Day, A S, Reddy, M, Golovkin
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Interactions of Cyclins with Cyclin-Dependent Kinases: A Common Interactive Mechanism
Biochemistry, 1997The formation of cdk-cyclin complexes has been investigated at the molecular level and quantified using spectroscopic approaches. In the absence of phosphorylation, cdk2, cdc2, and cdk7 form highly stable complexes with their "natural" cyclin partners with dissociation constants in the nanomolar range. In contrast, nonphosphorylated cdc2-cyclin H, cdk2-
Heitz, Frédéric +5 more
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The EMBO Journal, 1994
Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
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Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
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Cyclin I: A New Cyclin Encoded by a Gene Isolated from Human Brain
Experimental Cell Research, 1995A new member of the cyclin family has been isolated from an equalized cDNA library derived from human forebrain cortex. This putative cyclin, designated cyclin I, contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus.
T, Nakamura +5 more
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Cyclin A in nonfunctioning pituitary adenomas
Endocrine, 2020Assess cyclin A in nonfunctioning pituitary adenomas (NFPA) and compare its expression in non-invasive and non-proliferative tumors with invasive and proliferative tumors (12× higher risk of recurrence).Quantitative real time polymerase chain reaction to analyze cyclin A using normal pituitary gland as reference.
Elisa B. Lamback +8 more
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FOXM1c is activated by cyclin E/Cdk2, cyclin A/Cdk2, and cyclin A/Cdk1, but repressed by GSK-3α
Biochemical and Biophysical Research Communications, 2006Two different inhibitory domains, N-terminus and central domain, keep FOXM1c almost inactive despite its strong transactivation domain. Here, we demonstrate that cyclin E/Cdk2, cyclin A/Cdk2, and cyclin A/Cdk1 activate FOXM1c. Cyclin E/Cdk2 does not target its transactivation domain or its DNA-binding domain.
Inken, Wierstra, Jürgen, Alves
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Journal of Cell Science, 1995
ABSTRACT We have cloned cDNAs for Caenorhabditis elegans cyclins A1, B and B3. While cyclins A1 and B are most closely related to either A- or B-type cyclins of other species, cyclin B3 is less related to these cyclins. However, this cyclin is most similar to the recently identified chicken cyclin B3.
Kreutzer, M. +6 more
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ABSTRACT We have cloned cDNAs for Caenorhabditis elegans cyclins A1, B and B3. While cyclins A1 and B are most closely related to either A- or B-type cyclins of other species, cyclin B3 is less related to these cyclins. However, this cyclin is most similar to the recently identified chicken cyclin B3.
Kreutzer, M. +6 more
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Oncogenic activation of cyclin A
Current Opinion in Genetics & Development, 1993Cyclin A associates with both the p34 cdc2 and p33 cdk2 kinases and is involved at two major check-points (G1-S and G2-M) of the cell cycle. The cyclin has been identified in multimeric protein complexes that incorporate the E2F transcription factor, the p33 cdk2 kinase, and p107, which is related to the retinoblastoma protein.
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Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma
Journal of Oral Pathology & Medicine, 1999Cyclins play an important role in regulating the passage of dividing cells through critical checkpoints in cell cycle. Aberrant exprssion of cylcin proteins has been found in a number of human cancers, including carcinomas of the head and neck, where amplification of the cyclin D1 gene is a common finding. The obective of this study was to examine cell
J, Kushner +3 more
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