Results 31 to 40 of about 22,958,501 (389)
Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]
Cell, 1999 D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y +7 more
openaire +5 more sources
Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b) [PDF]
, 2009 Cyclin D1b is an alternative transcript of the cyclin D1 gene (CCND1) expressed in human tumors. Its abundance is regulated by a single base pair polymorphism at the exon 4/intron 4 boundary (nucleotide 870).
Benavides, Fernando +10 more
core +1 more source
Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1
BMC Research Notes, 2011 Background The elongation phase, like other steps of transcription by RNA Polymerase II, is subject to regulation. The positive transcription elongation factor b (P-TEFb) complex allows for the transition of mRNA synthesis to the productive elongation ...
Yu Wendong +2 more
doaj +1 more source
Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. [PDF]
PLoS Biology, 2007 Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry.
Arne Lindqvist +3 more
doaj +1 more source
The crystal structure of cyclin A [PDF]
Structure, 1995 Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs.
Brown NR +8 more
openaire +3 more sources
The cyclin D1b splice variant: an old oncogene learns new tricks
Cell Division, 2006 The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6 ...
Knudsen Karen E
doaj +1 more source
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Nature, 2020 Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid ...
Mikołaj Słabicki +23 more
semanticscholar +1 more source
Translational control of cyclins [PDF]
Cell Division, 2011 Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of regulatory mechanisms, permits a prompt response to signal transduction pathways induced by environmental stimuli.
Ming-Chih Lai, Woan-Yuh Tarn
openaire +4 more sources
Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]
, 2018 Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar +16 more
core +2 more sources
Viruses, 2016 The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is ...
Mirjam Steingruber +9 more
doaj +1 more source