Results 11 to 20 of about 470,056 (173)
Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B [PDF]
The EMBO Journal, 2020 Two mitotic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised functions in mitosis are incompletely understood. Using degron tags for rapid inducible protein removal, we analyse how acute depletion of these proteins affects mitosis. Loss of cyclin A in G2-phase prevents mitotic entry.
Alexis R. Barr +14 more
openaire +7 more sources
The 3' Untranslated Region of the Cyclin B mRNA Is Not Sufficient to Enhance the Synthesis of Cyclin B during a Mitotic Block in Human Cells [PDF]
PLoS ONE, 2013 Antimitotic agents are frequently used to treat solid tumors and hematologic malignancies. However, one major limitation of antimitotic approaches is mitotic slippage, which is driven by slow degradation of cyclin B during a mitotic block. The extent to which cyclin B levels decline is proposed to be governed by an equilibrium between cyclin B ...
Schnerch, Dominik Markus +4 more
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Activation of human B-MYB by cyclins [PDF]
Proceedings of the National Academy of Sciences, 1997 B-MYB expression is associated with cell proliferation and recent studies have suggested that it promotes the S phase of mammalian cells. Based on its homology to the transcription factors c-MYB and A-MYB, B-MYB is thought to be involved in transcriptional regulation; however, its activity is not detectable in several cell lines.
Sala A +10 more
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The Crystal Structure of Human Cyclin B [PDF]
Cell Cycle, 2007 Cyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a complex which initiates the mitotic program through phosphorylation of select proteins. Cyclin B regulates the activation, subcellular localization, and substrate specificity of cdk1, and destruction of cyclin B is ...
Edward T, Petri +4 more
openaire +3 more sources
Specialization and Targeting of B-Type Cyclins [PDF]
Molecular Cell, 1999 The B-type cyclins of S. cerevisiae are diversified with respect to time of expression during the cell cycle as well as biological function. We replaced the early-expressed CLB5 coding sequence with the late-expressed CLB2 coding sequence, at the CLB5 locus.
Frederick R. Cross +3 more
openaire +3 more sources
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. [PDF]
The EMBO Journal, 1994 We have shown previously that human cyclins A and B1 are localized differentially in the cell during interphase; cyclin A is nuclear and cyclin B1 is a cytoplasmic protein. To understand the basis of this difference we created deletion mutants and various chimeras between the two types of cyclin and expressed them in tissue culture cells by transient ...
Jonathon Pines, Tony Hunter
openaire +3 more sources
Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2 [PDF]
Cell Cycle, 2007 The transitions of the cell cycle are regulated by the cyclin dependent protein kinases (CDKs). The cyclins activate their respective CDKs and confer substrate recognition properties. We report the structure of phospho-CDK2/cyclin B and show that cyclin B confers M phase-like properties on CDK2, the kinase that is usually associated with S phase ...
Brown, Nick +5 more
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Mip/LIN-9 Regulates the Expression of B-Myb and the Induction of Cyclin A, Cyclin B, and CDK1 [PDF]
Journal of Biological Chemistry, 2007 Members of the novel family of proteins that include Drosophila Mip130, Caenorhabditis elegans LIN-9, and mammalian LIN-9 intervene in different cellular functions such as regulation of transcription, differentiation, transformation, and cell cycle progression. Here we demonstrate that LIN-9, designated as Mip/LIN-9, interacts with B-Myb but not with c-
Raudel Sandoval +4 more
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The double dealing of cyclin D1 [PDF]
Cell Cycle, Taylor & Francis, 2010, pp.1-16, 2020 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
arxiv +1 more source
The role of cyclin B in meiosis I. [PDF]
The Journal of cell biology, 1989 In clams, fertilization is followed by the prominent synthesis of two cyclins, A and B. During the mitotic cell cycles, the two cyclins are accumulated and then destroyed near the end of each metaphase. Newly synthesized cyclin B is complexed with a small set of other proteins, including a kinase that phosphorylates cyclin B in vitro.
Joanne M. Westendorf +2 more
openaire +3 more sources