Results 11 to 20 of about 13,609,830 (345)
The kinetics of G2 and M transitions regulated by B cyclins. [PDF]
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an ...
Yehong Huang +2 more
doaj +5 more sources
Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
doaj +7 more sources
The role of cyclin B in meiosis I [PDF]
The Journal of cell biology, 1989 In clams, fertilization is followed by the prominent synthesis of two cyclins, A and B. During the mitotic cell cycles, the two cyclins are accumulated and then destroyed near the end of each metaphase.
J. M. Westendorf +2 more
semanticscholar +4 more sources
Whole-genome analysis of animal A- and B-type cyclins. [PDF]
Genome Biology, 2011 BACKGROUND: Multiple A- and B-type cyclins have been identified in animals, but their study is complicated by varying degrees of functional redundancy. A non-essential phenotype may reflect redundancy with a known or as yet unknown gene.
Carrington, Mark +2 more
core +6 more sources
Mip/LIN-9 Regulates the Expression of B-Myb and the Induction of Cyclin A, Cyclin B, and CDK1* [PDF]
Journal of Biological Chemistry, 2007 Members of the novel family of proteins that include Drosophila Mip130, Caenorhabditis elegans LIN-9, and mammalian LIN-9 intervene in different cellular functions such as regulation of transcription, differentiation, transformation, and cell cycle ...
M. Pilkinton +4 more
semanticscholar +4 more sources
The Crystal Structure of Human Cyclin B [PDF]
Cell Cycle, 2007 Cyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a complex which initiates the mitotic program through phosphorylation of select proteins. Cyclin B regulates the activation, subcellular localization, and substrate specificity of cdk1, and destruction of cyclin B is ...
E. Petri +4 more
semanticscholar +4 more sources
Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2 [PDF]
Cell Cycle, 2007 The transitions of the cell cycle are regulated by the cyclin dependent protein kinases (CDKs). The cyclins activate their respective CDKs and confer substrate recognition properties. We report the structure of phospho-CDK2/cyclin B and show that cyclin B confers M phase-like properties on CDK2, the kinase that is usually associated with S phase ...
N. Brown +5 more
semanticscholar +4 more sources
Activation of human B-MYB by cyclins [PDF]
Proceedings of the National Academy of Sciences, 1997 B-MYB expression is associated with cell proliferation and recent studies have suggested that it promotes the S phase of mammalian cells. Based on its homology to the transcription factors c-MYB and A-MYB, B-MYB is thought to be involved in transcriptional regulation; however, its activity is not detectable in several cell lines.
Sala A +10 more
openaire +6 more sources
Specialization and Targeting of B-Type Cyclins [PDF]
Molecular Cell, 1999 The B-type cyclins of S. cerevisiae are diversified with respect to time of expression during the cell cycle as well as biological function. We replaced the early-expressed CLB5 coding sequence with the late-expressed CLB2 coding sequence, at the CLB5 locus.
Frederick R. Cross +3 more
openaire +3 more sources
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. [PDF]
The EMBO Journal, 1994 We have shown previously that human cyclins A and B1 are localized differentially in the cell during interphase; cyclin A is nuclear and cyclin B1 is a cytoplasmic protein. To understand the basis of this difference we created deletion mutants and various chimeras between the two types of cyclin and expressed them in tissue culture cells by transient ...
Jonathon Pines, Tony Hunter
openaire +3 more sources