Results 21 to 30 of about 12,781,724 (361)
The kinetics of G2 and M transitions regulated by B cyclins. [PDF]
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an ...
Yehong Huang +2 more
doaj +1 more source
Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
doaj +1 more source
Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
Cell Reports, 2020 Summary: Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for B cell malignancies. G1- to S-phase transition is dependent on the expression and stability of D-type cyclins.
Parham Ramezani-Rad +3 more
doaj +1 more source
A data-driven, mathematical model of mammalian cell cycle regulation. [PDF]
PLoS ONE, 2014 Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a
Michael C Weis +3 more
doaj +1 more source
PP2A function toward mitotic kinases and substrates during [PDF]
BMB Reports, 2013 To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex ...
Ae Lee Jeong, Young Yang
doaj +1 more source
Specialization and Targeting of B-Type Cyclins [PDF]
Molecular Cell, 1999 The B-type cyclins of S. cerevisiae are diversified with respect to time of expression during the cell cycle as well as biological function. We replaced the early-expressed CLB5 coding sequence with the late-expressed CLB2 coding sequence, at the CLB5 locus.
Cross, Frederick R +3 more
openaire +2 more sources
Molecules, 2021 Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2.
Ahmed Elkamhawy +6 more
doaj +1 more source
Genomic landscape of salivary gland tumors. [PDF]
, 2015 Effective treatment options for advanced salivary gland tumors are lacking. To better understand these tumors, we report their genomic landscape. We studied the molecular aberrations in 117 patients with salivary gland tumors that were, on physician ...
Carter, Jennifer L +6 more
core +5 more sources
Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
Cell Death Discovery, 2021 Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
Ariadna Recasens +13 more
doaj +1 more source
Interaction between Yeast Cdc6 Protein and B-Type Cyclin/Cdc28 Kinases [PDF]
, 1996 During purification of recombinant Cdc6 expressed in yeast, we found that Cdc6 interacts with the critical cell cycle, cyclin-dependent protein kinase Cdc28.
Campbell, Judith L. +4 more
core +1 more source