Results 21 to 30 of about 13,222,515 (326)

Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]

PLoS ONE, 2012
Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su, Tsunghan Yang, Hoting Huang, Leroy F Liu, Jaulang Hwang   +4 more
doaj   +1 more source

A data-driven, mathematical model of mammalian cell cycle regulation. [PDF]

PLoS ONE, 2014
Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a
Michael C Weis, Jayant Avva, James W Jacobberger, Sree N Sreenath   +3 more
doaj   +1 more source

PP2A function toward mitotic kinases and substrates during [PDF]

BMB Reports, 2013
To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex ...
Ae Lee Jeong, Young Yang
doaj   +1 more source

Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening

Molecules, 2021
Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2.
Ahmed Elkamhawy, Usama M. Ammar, Sora Paik, Magda H. Abdellattif, Mohamed H. Elsherbeny, Kyeong Lee, Eun Joo Roh   +6 more
doaj   +1 more source

Phosphorylation and activation of B-Myb by cyclin A–Cdk2 [PDF]

Current Biology, 1997
Cyclins and their catalytic partners, the cyclin-dependent kinases (Cdks), function as key regulators of the eukaryotic cell cycle. Specific cyclin-Cdk complexes are active at successive stages during the cell cycle and control cell-cycle progression by phosphorylating specific target proteins, most of which have not yet been identified.
Stefano Ferrari, Richard Marais, Ulrike Ziebold, Olaf Bartsch, Karl-Heinz Klempnauer   +4 more
openaire   +3 more sources

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

Cell Death Discovery, 2021
Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
Ariadna Recasens, Sean J. Humphrey, Michael Ellis, Monira Hoque, Ramzi H. Abbassi, Brianna Chen, Mitchell Longworth, Elise J. Needham, David E. James, Terrance G. Johns, Bryan W. Day, Michael Kassiou, Pengyi Yang, Lenka Munoz   +13 more
doaj   +1 more source

Inhibition of membrane fusion in vitro via cyclin B but not cyclin A.

Journal of Biological Chemistry, 1992
It is now clear that complexes of cdc2 kinase with "mitotic" cyclins regulate the transition between the G2 phase of the cell cycle and mitosis and that membrane traffic in mammalian cells is arrested during mitosis. Using a cell-free assay, we have previously reported that the fusion of early endosomes is, in fact, inhibited via the cdc2 kinase ...
Thomas, Leo, Clarke, P. R., Pagano, Michele, Gruenberg, Jean   +3 more
openaire   +3 more sources

Cyclin A triggers Mitosis either via Greatwall or Cyclin B [PDF]

, 2018
AbstractTwo mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1.
Hégarat, Nadia, Crncec, Adrijana, Peredoa Rodri-guez, Maria F. Suarez, Iturra, Fabio Echegaray, Gu, Yan, Lang, Paul F., Barr, Alexis R., Bakal, Chris, Kanemaki, Masato T., Lamond, Angus I., Novak, Bela, Ly, Tony, Hochegger, Helfrid   +12 more
openaire   +2 more sources

The roles of Drosophila cyclins A and B in mitotic control [PDF]

Cell, 1990
We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis.
Patrick H. O'Farrell, Christian F. Lehner   +1 more
openaire   +3 more sources

Regulation of B-Myb activity by cyclin D1 [PDF]

Oncogene, 2000
Evidence obtained during recent years suggests that B-Myb, a highly conserved member of the Myb transcription factor family, plays a key role in cell proliferation. We have shown previously that the activity of B-Myb is stimulated by cyclin A/Cdk2-dependent phosphorylation of the carboxyl-terminus of B-Myb.
Karl-Heinz Klempnauer, Sebastian Horstmann, Stefano Ferrari   +2 more
openaire   +3 more sources