Results 21 to 30 of about 13,609,830 (345)
A data-driven, mathematical model of mammalian cell cycle regulation. [PDF]
PLoS ONE, 2014 Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a
Michael C Weis +3 more
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PP2A function toward mitotic kinases and substrates during [PDF]
BMB Reports, 2013 To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex ...
Ae Lee Jeong, Young Yang
doaj +1 more source
The double dealing of cyclin D1 [PDF]
Cell Cycle, Taylor & Francis, 2010, pp.1-16, 2020 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
arxiv +1 more source
Molecules, 2021 Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2.
Ahmed Elkamhawy +6 more
doaj +1 more source
CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]
, 2013 Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
A Sourirajan +38 more
core +7 more sources
Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
Cell Death Discovery, 2021 Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
Ariadna Recasens +13 more
doaj +1 more source
Phosphorylation and activation of B-Myb by cyclin A–Cdk2 [PDF]
Current Biology, 1997 Cyclins and their catalytic partners, the cyclin-dependent kinases (Cdks), function as key regulators of the eukaryotic cell cycle. Specific cyclin-Cdk complexes are active at successive stages during the cell cycle and control cell-cycle progression by phosphorylating specific target proteins, most of which have not yet been identified.
Stefano Ferrari +4 more
openaire +3 more sources
Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins [PDF]
, 2002 Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cell cycle in G2/M.
Fung, Tsz Kan +4 more
core +1 more source
Profiles of cyclin B and cdc2 during ovarian and embryonic development in Exopalaemon carinicauda [PDF]
, 2023 Mitosis-promoting factor (MPF) is a complex formed by cyclin B (cyclin B) and cyclin-dependent kinase (cdc2). To investigate the role of MPF in the reproduction of Exopalaemon carinicauda, we cloned its full-length cDNA of the Ec-cyclin B and Ec-cdc2 ...
Li, Hui +7 more
core +2 more sources
Inhibition of membrane fusion in vitro via cyclin B but not cyclin A.
Journal of Biological Chemistry, 1992 It is now clear that complexes of cdc2 kinase with "mitotic" cyclins regulate the transition between the G2 phase of the cell cycle and mitosis and that membrane traffic in mammalian cells is arrested during mitosis. Using a cell-free assay, we have previously reported that the fusion of early endosomes is, in fact, inhibited via the cdc2 kinase ...
Thomas, Leo +3 more
openaire +3 more sources