Results 21 to 30 of about 470,056 (173)
Phosphorylation and activation of B-Myb by cyclin A–Cdk2 [PDF]
Current Biology, 1997 Cyclins and their catalytic partners, the cyclin-dependent kinases (Cdks), function as key regulators of the eukaryotic cell cycle. Specific cyclin-Cdk complexes are active at successive stages during the cell cycle and control cell-cycle progression by phosphorylating specific target proteins, most of which have not yet been identified.
Stefano Ferrari +4 more
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Cyclin A triggers Mitosis either via Greatwall or Cyclin B [PDF]
, 2018 AbstractTwo mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1.
Hégarat, Nadia +12 more
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The roles of Drosophila cyclins A and B in mitotic control [PDF]
Cell, 1990 We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis.
Patrick H. O'Farrell +1 more
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Inhibition of membrane fusion in vitro via cyclin B but not cyclin A.
Journal of Biological Chemistry, 1992 It is now clear that complexes of cdc2 kinase with "mitotic" cyclins regulate the transition between the G2 phase of the cell cycle and mitosis and that membrane traffic in mammalian cells is arrested during mitosis. Using a cell-free assay, we have previously reported that the fusion of early endosomes is, in fact, inhibited via the cdc2 kinase ...
Thomas, L +3 more
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Regulation of B-Myb activity by cyclin D1 [PDF]
Oncogene, 2000 Evidence obtained during recent years suggests that B-Myb, a highly conserved member of the Myb transcription factor family, plays a key role in cell proliferation. We have shown previously that the activity of B-Myb is stimulated by cyclin A/Cdk2-dependent phosphorylation of the carboxyl-terminus of B-Myb.
Karl-Heinz Klempnauer +2 more
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The ‘destruction box’ of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed. [PDF]
The EMBO Journal, 1996 The destruction of mitotic cyclins by programmed proteolysis at the end of mitosis is an important element in cell cycle control. This proteolysis depends on a conserved motif of nine residues known as the 'destruction box', which is located 40-50 residues from the N-terminus. The sequences of the A- and B-type destruction boxes are slightly different,
A Klotzbücher +3 more
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A model for regulation of the cell cycle incorporating cyclin A, cyclin B and their complexes
Cell Proliferation, 1994 Abstract. t. A mathematical model for the cell cycle is proposed that incorporates the known biochemical reactions involving both cyclin A and cyclin B, the interactions of these cyclins with cdc2 and cdk2, and the controlling effects of cdc25 and weel.
Mandri N. Obeyesekere +2 more
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Cyclin B targets p34cdc2 for tyrosine phosphorylation. [PDF]
The EMBO Journal, 1991 A universal intracellular factor, the 'M phase-promoting factor' (MPF), triggers the G2/M transition of the cell cycle in all organisms. In late G2, it is present as an inactive complex of tyrosine-phosphorylated p34cdc2 and unphosphorylated cyclin Bcdc13.
L. Azzi, J. Y. J. Wang, Laurent Meijer
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A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets [PDF]
arXiv, 2023 The regulatory mechanisms driving progression of the yeast cell cycle appears to be comprised of an interacting network of transcription factors (TFs), cyclin-dependent kinases (CDK) and ubiquitin ligases. From a systems perspective the controlling regulatory network must produce robust periodic behavior during proliferative phases, but have the ...
arxiv
A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. [PDF]
The EMBO Journal, 1993 Both cyclins A and B associate with and thereby activate cyclin-dependent protein kinases (cdks). We have investigated which component in the cyclin-cdk complex determines its substrate specificity. The A- and B-type cyclin-cdk complexes phosphorylated histone H1 and their cyclin subunits in an indistinguishable manner, irrespective of the catalytic ...
H. Piwnica-Worms +8 more
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