Results 21 to 30 of about 327,465 (302)
Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
Cell Death Discovery, 2021 Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
Ariadna Recasens +13 more
doaj +1 more source
Interaction between Yeast Cdc6 Protein and B-Type Cyclin/Cdc28 Kinases [PDF]
, 1996 During purification of recombinant Cdc6 expressed in yeast, we found that Cdc6 interacts with the critical cell cycle, cyclin-dependent protein kinase Cdc28.
Campbell, Judith L. +4 more
core +1 more source
The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators [PDF]
, 1999 The entry into mitosis is controlled by Cdc2/cyclin B, also known as maturation or M-phase promoting factor (MPF). In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the ...
Dunphy, William G. +3 more
core +1 more source
Overexpression of B-type cyclins alters chromosomal segregation [PDF]
Oncogene, 2002 To identify genes which overexpression results into chromosomal instability (CIN), we developed a biological approach based on a yeast indicator strain in which CIN can be detected by a sectoring phenotype. Screening in this strain of a yeast genomic library cloned into a high copy vector led us to identify, among the clones generating 100% of ...
Nasrin, Sarafan-Vasseur +8 more
openaire +2 more sources
Whole-genome analysis of animal A- and B-type cyclins. [PDF]
, 2011 BACKGROUND: Multiple A- and B-type cyclins have been identified in animals, but their study is complicated by varying degrees of functional redundancy. A non-essential phenotype may reflect redundancy with a known or as yet unknown gene.
Carrington, Mark +2 more
core +1 more source
Regulation of B-Myb activity by cyclin D1 [PDF]
Oncogene, 2000 Evidence obtained during recent years suggests that B-Myb, a highly conserved member of the Myb transcription factor family, plays a key role in cell proliferation. We have shown previously that the activity of B-Myb is stimulated by cyclin A/Cdk2-dependent phosphorylation of the carboxyl-terminus of B-Myb.
S, Horstmann +2 more
openaire +2 more sources
BMC Complementary and Alternative Medicine, 2018 Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park +7 more
doaj +1 more source
Cyclin D2controls B cell progenitor numbers [PDF]
Journal of Leukocyte Biology, 2003 AbstractCyclin D2 affects B cell proliferation and differentiation in vivo. It is rate-limiting for B cell receptor (BCR)-dependent proliferation of B cells, and cyclin D2−/− mice lack CD5+(B1) B lymphocytes. We show here that the bone marrow (BM) of cyclin D2−/− mice contains half the numbers of Sca1+B220+ B cell progenitors but normal levels of Sca1+
Mohamedali, A Z +7 more
openaire +3 more sources
Activation of p34cdc2 kinase by cyclin A [PDF]
, 1991 Functional clam cyclin A and B proteins have been produced using a baculovirus expression system. Both cyclin A and B can induce meiosis I and meiosis II in Xenopus in the absence of protein synthesis.
Gabrielli, B. G. +6 more
core +1 more source
Cyclin A triggers Mitosis either via Greatwall or Cyclin B [PDF]
, 2018 AbstractTwo mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1.
Hégarat, Nadia +12 more
openaire +1 more source