Results 31 to 40 of about 470,056 (173)
Whole-genome analysis of animal A- and B-type cyclins [PDF]
Genome Biology, 2002 Multiple A- and B-type cyclins have been identified in animals, but their study is complicated by varying degrees of functional redundancy. A non-essential phenotype may reflect redundancy with a known or as yet unknown gene. Complete sequencing of several animal genomes has allowed us to determine the size of the mitotic cyclin gene family and ...
Nieduszynski, Conrad A. +2 more
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Phosphorylation of AIB1 at Mitosis Is Regulated by CDK1/CYCLIN B
PLoS ONE, 2011 Although the AIB1 oncogene has an important role during the early phase of the cell cycle as a coactivator of E2F1, little is known about its function during mitosis.Mitotic cells isolated by nocodazole treatment as well as by shake-off revealed a post-translational modification occurring in AIB1 specifically during mitosis.
Ferrero, Macarena +6 more
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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation [PDF]
, 2018 p27$^{Kip1}$ (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)$/$cyclin complexes (e.g., Cdk2$/$cyclin A), inhibiting their catalytic activity and causing cell cycle arrest. However, cell division progresses when stably Cdk2$/$cyclin A-bound p27 is phosphorylated on one or two structurally ...
arxiv +1 more source
Cyclin B-Cdk1 Controls Pronuclear Union in Interphase [PDF]
Current Biology, 2008 In sexual reproduction, the union of the male and female pronuclei occurs in fertilized eggs to mix genetic materials derived from both parents, thereby creating a new genome for the next generation [1-4]. The process leading to pronuclear union consists of pronuclear congression, which depends on astral microtubules derived from sperm centrosome [5-8],
Kazunori Tachibana +3 more
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Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations [PDF]
Journal of Medicinal Chemistry 49, 5141-5153 (2006), 2008 The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to ...
arxiv +1 more source
Using a hydrogen-bond index to predict the gene-silencing efficiency of siRNA based on the local structure of mRNA [PDF]
Biochem Biophys Res Comms, vol.320 (2) 622 (2004), 2017 The gene silencing effect of short interfering RNA (siRNA) is known to vary strongly with the targeted position of the mRNA. A number of hypotheses have been suggested to explain this phenomenon. We would like to test if this positional effect is mainly due to the secondary structure of the mRNA at the target site.
arxiv +1 more source
Investigation of the impact of PTMs on the protein backbone conformation [PDF]
Amino Acids, Springer Verlag, 2019, 51 (7), pp.1065-1079, 2019 Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder regions have already been spotted on the past decade. Nonetheless, the high diversity of PTMs types, and the multiple schemes of protein modifications (multiple PTMs, of ...
arxiv +1 more source
Mechanisms and regulation of the degradation of cyclin B
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999 The degradation of the cyclin B subunit of protein kinase Cdk1/cyclin B is required for inactivation of the kinase and exit from mitosis. Cyclin B is degraded by the ubiquitin pathway, a system involved in most selective protein degradation in eukaryotic cells.
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Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B [PDF]
Genes & Development, 1998 Cyclin B3 has been conserved during higher eukaryote evolution as evidenced by its identification in chicken, nematodes, and insects. We demonstrate that Cyclin B3 is present in addition to Cyclins A and B in mitotically proliferating cells and not detectable in endoreduplicating tissues of Drosophila embryos.
Jürgen A. Knoblich +2 more
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Overexpression of B-type cyclins alters chromosomal segregation [PDF]
Oncogene, 2002 To identify genes which overexpression results into chromosomal instability (CIN), we developed a biological approach based on a yeast indicator strain in which CIN can be detected by a sectoring phenotype. Screening in this strain of a yeast genomic library cloned into a high copy vector led us to identify, among the clones generating 100% of ...
Jeannette Bourguignon +8 more
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