Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]
, 2014 Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Amalie E. Dick +36 more
core +1 more source
Cyclin A triggers Mitosis either via Greatwall or Cyclin B [PDF]
, 2018 AbstractTwo mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1.
Hégarat, Nadia +12 more
openaire +2 more sources
The roles of Drosophila cyclins A and B in mitotic control [PDF]
Cell, 1990 We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis.
Patrick H. O'Farrell +1 more
openaire +3 more sources
The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators [PDF]
, 1999 The entry into mitosis is controlled by Cdc2/cyclin B, also known as maturation or M-phase promoting factor (MPF). In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the ...
Dunphy, William G. +3 more
core +1 more source
Regulation of B-Myb activity by cyclin D1 [PDF]
Oncogene, 2000 Evidence obtained during recent years suggests that B-Myb, a highly conserved member of the Myb transcription factor family, plays a key role in cell proliferation. We have shown previously that the activity of B-Myb is stimulated by cyclin A/Cdk2-dependent phosphorylation of the carboxyl-terminus of B-Myb.
Karl-Heinz Klempnauer +2 more
openaire +3 more sources
BMC Complementary and Alternative Medicine, 2018 Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park +7 more
doaj +1 more source
Carrying-over effects of GVBD blocking on post-blocking meiotic progression of oocytes: species difference and the signaling pathway leading to MPF activation. [PDF]
PLoS ONE, 2014 Efforts to improve the quality of in vitro matured oocytes by blocking germinal vesicle breakdown (GVBD) and allowing more time for ooplasmic maturation have achieved little due to a lack of knowledge on the molecular events during GVBD blocking.
Guang-Zhong Jiao +7 more
doaj +1 more source
Activation of p34cdc2 kinase by cyclin A [PDF]
, 1991 Functional clam cyclin A and B proteins have been produced using a baculovirus expression system. Both cyclin A and B can induce meiosis I and meiosis II in Xenopus in the absence of protein synthesis.
Gabrielli, B. G. +6 more
core +1 more source
Cyclin B–Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase–independent mechanism
Journal of Cell Biology, 2014 The role of Greatwall kinase in autoregulatory activation of cyclin B–Cdk1 at M phase onset can be bypassed by cyclin B–Cdk1–mediated direct phosphorylation of Arpp19, leading to PP2A-B55 inhibition.
E. Okumura +5 more
semanticscholar +1 more source
Characterization and localization of cyclin B3 transcript in both oocyte and spermatocyte of the rainbow trout (Oncorhynchus mykiss) [PDF]
PeerJ, 2019 B-type cyclins are regulatory subunits with distinct roles in the cell cycle. To date, at least three subtypes of B-type cyclins (B1, B2, and B3) have been identified in vertebrates. Previously, we reported the characterization and expression profiles of
Wenzhi Guan +5 more
doaj +2 more sources