Results 31 to 40 of about 12,781,724 (361)

Whole-genome analysis of animal A- and B-type cyclins. [PDF]

, 2011
BACKGROUND: Multiple A- and B-type cyclins have been identified in animals, but their study is complicated by varying degrees of functional redundancy. A non-essential phenotype may reflect redundancy with a known or as yet unknown gene.
Carrington, Mark, Murray, James, Nieduszynski, Conrad A   +2 more
core   +1 more source

Overexpression of B-type cyclins alters chromosomal segregation [PDF]

Oncogene, 2002
To identify genes which overexpression results into chromosomal instability (CIN), we developed a biological approach based on a yeast indicator strain in which CIN can be detected by a sectoring phenotype. Screening in this strain of a yeast genomic library cloned into a high copy vector led us to identify, among the clones generating 100% of ...
Nasrin, Sarafan-Vasseur, Aude, Lamy, Jeannette, Bourguignon, Florence, Le Pessot, Philip, Hieter, Richard, Sesboüé, Christian, Bastard, Thierry, Frébourg, Jean-Michel, Flaman   +8 more
openaire   +2 more sources

The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators [PDF]

, 1999
The entry into mitosis is controlled by Cdc2/cyclin B, also known as maturation or M-phase promoting factor (MPF). In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the ...
Dunphy, William G., Kumagai, Akiko, Patra, Debabrata, Wang, Sophie X.   +3 more
core   +1 more source

Regulation of B-Myb activity by cyclin D1 [PDF]

Oncogene, 2000
Evidence obtained during recent years suggests that B-Myb, a highly conserved member of the Myb transcription factor family, plays a key role in cell proliferation. We have shown previously that the activity of B-Myb is stimulated by cyclin A/Cdk2-dependent phosphorylation of the carboxyl-terminus of B-Myb.
S, Horstmann, S, Ferrari, K H, Klempnauer   +2 more
openaire   +2 more sources

Ethanol extracts from the branch of Taxillus yadoriki parasitic to Neolitsea sericea induces cyclin D1 proteasomal degradation through cyclin D1 nuclear export

BMC Complementary and Alternative Medicine, 2018
Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park, Gwang Hun Park, Ha Na Kim, Hun Min Song, Ho-Jun Son, Ji Ae Park, Hyun-Seok Kim, Jin Boo Jeong   +7 more
doaj   +1 more source

Activation of p34cdc2 kinase by cyclin A [PDF]

, 1991
Functional clam cyclin A and B proteins have been produced using a baculovirus expression system. Both cyclin A and B can induce meiosis I and meiosis II in Xenopus in the absence of protein synthesis.
Gabrielli, B. G., Li, R. S., Maller, J. L., Piwnicaworms, H., Roy, L. M., Swenson, K. I., Walker, D. H.   +6 more
core   +1 more source

Cyclin D2controls B cell progenitor numbers [PDF]

Journal of Leukocyte Biology, 2003
AbstractCyclin D2 affects B cell proliferation and differentiation in vivo. It is rate-limiting for B cell receptor (BCR)-dependent proliferation of B cells, and cyclin D2−/− mice lack CD5+(B1) B lymphocytes. We show here that the bone marrow (BM) of cyclin D2−/− mice contains half the numbers of Sca1+B220+ B cell progenitors but normal levels of Sca1+
Mohamedali, A Z, Soeiro, I, Lea, N C, Glassford, J, Banerji, L, Mufti, G J, Lam, E W F, Thomas, N S B   +7 more
openaire   +3 more sources

Cyclin A triggers Mitosis either via Greatwall or Cyclin B [PDF]

, 2018
AbstractTwo mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1.
Hégarat, Nadia, Crncec, Adrijana, Peredoa Rodri-guez, Maria F. Suarez, Iturra, Fabio Echegaray, Gu, Yan, Lang, Paul F., Barr, Alexis R., Bakal, Chris, Kanemaki, Masato T., Lamond, Angus I., Novak, Bela, Ly, Tony, Hochegger, Helfrid   +12 more
openaire   +1 more source

Cyclin B-Cdk1 Controls Pronuclear Union in Interphase [PDF]

Current Biology, 2008
In sexual reproduction, the union of the male and female pronuclei occurs in fertilized eggs to mix genetic materials derived from both parents, thereby creating a new genome for the next generation [1-4]. The process leading to pronuclear union consists of pronuclear congression, which depends on astral microtubules derived from sperm centrosome [5-8],
Kazunori Tachibana, Masatoshi Hara, Yukako Hattori, Takeo Kishimoto   +3 more
openaire   +2 more sources

Carrying-over effects of GVBD blocking on post-blocking meiotic progression of oocytes: species difference and the signaling pathway leading to MPF activation. [PDF]

PLoS ONE, 2014
Efforts to improve the quality of in vitro matured oocytes by blocking germinal vesicle breakdown (GVBD) and allowing more time for ooplasmic maturation have achieved little due to a lack of knowledge on the molecular events during GVBD blocking.
Guang-Zhong Jiao, Hua-Yu Lian, Yan Gao, Ming-Ju Sun, Shuai Gong, Liang-Liang Zheng, Chuan-Xin Zhang, Jing-He Tan   +7 more
doaj   +1 more source