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The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2010
Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis.
Jiping ZHU, Like YU, Ping ZHAN, Yong SONG, Qin WANG   +4 more
doaj   +3 more sources

Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma [PDF]

Acta Pharmaceutica Sinica B
Cyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers. Here, we demonstrated that cyclin D1 is SUMOylated, and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating
Ke Lu, Ming Zhang, Hongyu Qin, Siyu Shen, Haiqing Song, Hua Jiang, Chunxiang Zhang, Guozhi Xiao, Liping Tong, Qing Jiang, Di Chen   +10 more
doaj   +2 more sources

Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma [PDF]

The Journal of Clinical Investigation
Oncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MMEJ).
Jithma P. Abeykoon, Shuhei Asada, Guangli Zhu, Yuna Hirohashi, Lisa Moreau, Divya Iyer, Sirisha Mukkavalli, Kalindi Parmar, Gabriella Zambrano, Lige Jiang, Dongni Yi, Michelle Manske, Kimberly Gwin, Rebecca L. King, James R. Cerhan, Xiaosheng Wu, Zhenkun Lou, Geoffrey I. Shapiro, Thomas Witzig, Alan D’Andrea   +19 more
doaj   +2 more sources

Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis [PDF]

eLife
In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.
Nelson García-Vázquez, Tania J González-Robles, Ethan Lane, Daria Spasskaya, Qingyue Zhang, Marc A Kerzhnerman, YeonTae Jeong, Marta Collu, Daniele Simoneschi, Kelly V Ruggles, Gergely Róna, Sharon Kaisari, Michele Pagano   +12 more
doaj   +2 more sources

Cyclin D1: A Prognostic Marker in Multiple Myeloma and its Association with CRP and β2-Microglobulin Level [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Cyclin D1 is a protein encoded by the CCND1 (BCL-1) gene on chromosome 11q13 and it is an important regulator of G1 to S phase progression. Over expression of cyclin D1 protein releases cells from their normal controls when they need to
Amrita Singh, Rashmi Kushwaha, Geeta Yadav, Shailendra Prasad Verma, Wahid Ali, Mili Jain, Pooja Dwivedi, Uma Shankar Singh   +7 more
doaj   +1 more source

Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability

eLife, 2023
Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression.
Ke Lu, Ming Zhang, Guizheng Wei, Guozhi Xiao, Liping Tong, Di Chen   +5 more
doaj   +1 more source

Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma [PDF]

International Journal of Medical Arts, 2021
Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors.
Shimaa Abu_Seadah, Samah Attiah, Mohamed Ali   +2 more
doaj   +1 more source

Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma

Frontiers in Oncology, 2023
Cyclin D1 functions as a mitogenic sensor that specifically binds to CDK4/6, thereby integrating external mitogenic inputs and cell cycle progression.
Wei Cai, Lin-Zhen Shu, Ding-Jie Liu, Lv Zhou, Meng-Meng Wang, Huan Deng   +5 more
doaj   +1 more source

A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. [PDF]

PLoS ONE, 2006
Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in
Hiroshi Okabe, Sang-Hyun Lee, Janyaporn Phuchareon, Donna G Albertson, Frank McCormick, Osamu Tetsu   +5 more
doaj   +1 more source

P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. [PDF]

PLoS ONE, 2012
BackgroundThe different mechanisms involved in p120-catenin (p120ctn) isoforms' 1/3 regulation of cell cycle progression are still not elucidated to date.Methods and findingsWe found that both cyclin D1 and cyclin E could be effectively restored by ...
Guiyang Jiang, Yan Wang, Shundong Dai, Yang Liu, Maggie Stoecker, Endi Wang, Enhua Wang   +6 more
doaj   +1 more source