Results 1 to 10 of about 151,940 (306)

Cyclin D1 expression in prostate carcinoma [PDF]

Brazilian Journal of Medical and Biological Research, 2014
The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved
Pereira, R.A., Ravinal, R.C., Costa, R.S., Lima, M.S., Tucci, S., Muglia, V.F., Dos Reis, R.B., Silva, G.E.B.   +7 more
openaire   +5 more sources

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention [PDF]

Molecular Cancer, 2007
Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 degradation appears to be
Alao, John P
core   +5 more sources

The cyclin D1b splice variant: an old oncogene learns new tricks [PDF]

Cell Division, 2006
The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6 ...
Knudsen, Karen E
core   +5 more sources

A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation [PDF]

PLoS ONE, 2006
Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in
A Hershko, A Montagnoli, A Russell, AD Sharrocks, AJ Bardwell, CJ Sherr, DC Dias, DM Koepp, Dong-Yan Jin, Donna G. Albertson, Frank McCormick, H Matsushime, Hiroshi Okabe, J Jin, J LaBaer, J Shao, JA Diehl, JA Diehl, JA Diehl, Janyaporn Phuchareon, JR Alt, K Nakayama, K Nakayama, M Cheng, M Malumbres, MF Favata, O Casanovas, O Tetsu, O Tetsu, Osamu Tetsu, Q Yu, RJ Deshaies, S Ganiatsas, Sang-Hyun Lee, SG Macdonald, SP Davies, T Arai, T Cardozo, V Baldin, Y Guo, Y Guo   +40 more
core   +11 more sources

The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer [PDF]

Chinese Journal of Lung Cancer, 2010
Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis.
Jiping ZHU, Like YU, Ping ZHAN, Qin WANG, Yong SONG   +4 more
core   +2 more sources

Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgenindependent prostate cancer cells to DNA damage. [PDF]

Aging, 2015
Patients with hormone-resistant prostate cancer (PCa) have higher biochemical failure rates following radiation therapy (RT). Cyclin D1 deregulated expression in PCa is associated with a more aggressive disease: however its role in radioresistance has ...
Casimiro, Mathew C, Colapietro, A, Di Cesare, E, Festuccia, C, Gaudio, E, Gravina, G L, Ju, Xiaoming, Marampon, F, Pestell, Richard, Pompili, S, Sferra, R, Tombolini, V, Vetuschi, A   +12 more
core   +13 more sources

Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation [PDF]

Cell Division, 2008
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl, J Alan, Pontano, Laura L
core   +5 more sources

Cyclin d1 induces chromosomal instability. [PDF]

Oncotarget, 2012
We developed mouse model systems to investigate the potential for cyclin D1 to induce CIN in vivo. In a mammary gland specific Tet-inducible model the acute expression profile regulated by cyclin D1 after 7 days was enriched in genes that rank highly ...
Casimiro, Mathew C, Pestell, Richard
core   +6 more sources

Epstein-Barr Virus Nuclear Antigen 3C Facilitates G1-S Transition by Stabilizing and Enhancing the Function of Cyclin D1 [PDF]

PLoS Pathogens, 2011
EBNA3C, one of the Epstein-Barr virus (EBV)-encoded latent antigens, is essential for primary B-cell transformation. Cyclin D1, a key regulator of G1 to S phase progression, is tightly associated and aberrantly expressed in numerous human cancers ...
A Rosendorff, A Saha, Abhik Saha, AJ Sinclair, BG Bajaj, Blossom Damania, C Subramanian, C Subramanian, CH Park, CJ Sherr, DI Lin, E Campo, E Kieff, Erle S. Robertson, ES Robertson, F Yi, GA Parker, GA Parker, H Lovec, H Nakagawa, HR Kim, I Palmero, J Bartkova, J Bloom, J Lu, J O'Nions, J O'Nions, J Ponten, J Zwicker, JA Diehl, Jie Lu, JK Kim, JL Siegert, JP Alao, JS Knight, JS Knight, JS Knight, JS Knight, JS Knight, L Arvanitakis, LL Pontano, M Bain, M Klier, M Meyyappan, MA Cotter 2nd, Masanao Murakami, ME Williams, MF Buckley, P Jares, Pankaj Kumar, Qiliang Cai, R Touitou, S Benzeno, S Ganiatsas, S Gansauge, S Halder, S Maruo, S Maruo, Sabyasachi Halder, Santosh K. Upadhyay, T Choudhuri, T Motokura, UK Laemmli, V Baldin, X Yan, Y Murai, Y Yatabe, Y Zhou, ZK Yu   +68 more
core   +5 more sources

Cyclin D1: A Prognostic Marker in Multiple Myeloma and its Association with CRP and β2-Microglobulin Level [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Cyclin D1 is a protein encoded by the CCND1 (BCL-1) gene on chromosome 11q13 and it is an important regulator of G1 to S phase progression. Over expression of cyclin D1 protein releases cells from their normal controls when they need to
Amrita Singh, Rashmi Kushwaha, Geeta Yadav, Shailendra Prasad Verma, Wahid Ali, Mili Jain, Pooja Dwivedi, Uma Shankar Singh   +7 more
doaj   +1 more source