The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention [PDF]
Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 degradation appears to be
Alao John P
doaj +5 more sources
Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. [PDF]
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by
Bisetto, Sara+17 more
core +3 more sources
Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability [PDF]
Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression.
Ke Lu+5 more
doaj +2 more sources
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis [PDF]
Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics.
Addya, Sankar+18 more
core +2 more sources
The cyclin D1b splice variant: an old oncogene learns new tricks [PDF]
The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6 ...
Knudsen Karen E
doaj +4 more sources
The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer [PDF]
Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis.
Jiping ZHU+4 more
doaj +1 more source
Prognostic significance of cyclin D1 protein expression and gene amplification in invasive breast carcinoma. [PDF]
The oncogenic capacity of cyclin D1 has long been established in breast cancer. CCND1 amplification has been identified in a subset of patients with poor prognosis, but there are conflicting data regarding the predictive value of cyclin D1 protein ...
Angela B Ortiz+5 more
doaj +2 more sources
Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation [PDF]
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
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A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. [PDF]
Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in
Hiroshi Okabe+5 more
doaj +5 more sources
P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. [PDF]
BackgroundThe different mechanisms involved in p120-catenin (p120ctn) isoforms' 1/3 regulation of cell cycle progression are still not elucidated to date.Methods and findingsWe found that both cyclin D1 and cyclin E could be effectively restored by ...
Guiyang Jiang+6 more
doaj +6 more sources