Cyclin D1 expression in prostate carcinoma [PDF]
Brazilian Journal of Medical and Biological Research, 2014 The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma.
R.A. Pereira +7 more
doaj +4 more sources
Cyclin D1 expression in penile cancer. [PDF]
OncotargetThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017.
Duarte WE +11 more
europepmc +3 more sources
Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma [PDF]
The Journal of Clinical InvestigationOncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MMEJ).
Jithma P. Abeykoon +19 more
doaj +2 more sources
Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis [PDF]
eLifeIn healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.
Nelson García-Vázquez +12 more
doaj +2 more sources
Cyclin D1: A Prognostic Marker in Multiple Myeloma and its Association with CRP and β2-Microglobulin Level [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Cyclin D1 is a protein encoded by the CCND1 (BCL-1) gene on chromosome 11q13 and it is an important regulator of G1 to S phase progression. Over expression of cyclin D1 protein releases cells from their normal controls when they need to
Amrita Singh +7 more
doaj +1 more source
Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
eLife, 2023 Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression.
Ke Lu +5 more
doaj +1 more source
Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma [PDF]
International Journal of Medical Arts, 2021 Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors.
Shimaa Abu_Seadah +2 more
doaj +1 more source
Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma
Frontiers in Oncology, 2023 Cyclin D1 functions as a mitogenic sensor that specifically binds to CDK4/6, thereby integrating external mitogenic inputs and cell cycle progression.
Wei Cai +5 more
doaj +1 more source
Cyclin D1 in parathyroid disease [PDF]
Frontiers in Bioscience, 2000 Primary hyperparathyroidism (HPT), most commonly due to parathyroid adenoma, is a disorder characterized by excessive secretion of PTH. So far, abnormalities in two genes, cyclin D1 and MEN1, have been implicated in the development of parathyroid adenomas.
S M, Mallya, A, Arnold
openaire +2 more sources
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. [PDF]
PLoS ONE, 2006 Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in
Hiroshi Okabe +5 more
doaj +1 more source