Results 101 to 110 of about 152,964 (318)

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Advanced Science, EarlyView.
Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin   +10 more
wiley   +1 more source

The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells [PDF]

, 2015
International audienceAbstractBackgroundThe family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual
Azogui, Orly, Barinov, Aleksandr, Chaves-Ferreira, Miguel, Cumano, Ana, Gonçalves, Pedro, Krenn, Gerald, Laderach, Diego, Li, Zhi, Pellegrini, Sandra, Rocha, Benedita, Vasseur, Florence   +10 more
core   +9 more sources

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells [PDF]

, 2010
The Notch signaling pathway controls cell fate choices at multiple steps during cell lineage progression. To produce the cell fate choice appropriate for a particular stage in the cell lineage, Notch signaling needs to interpret the cell context ...
Andersson, Emma R., Bergmann, Olaf, Das, Debashish, Hansson, Emil M., Heldring, Nina, Hermanson, Ola, Lanner, Fredrik, Lendahl, Urban, Main, Heather, Sahlgren, Cecilia   +9 more
core   +1 more source

Degradation strategy of cyclin D1 in cancer cells and the potential clinical application

Frontiers in Oncology, 2022
Cyclin D1 has been reported to be upregulated in several solid and hematologic tumors, promoting cancer progression. Thus, decreasing cyclin D1 by degradation could be a promising target strategy for cancer therapy.
Shuyi Chen, Ling Li
doaj   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma

World Journal of Surgical Oncology, 2012
Background Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters and prognosis in oral cavity squamous cell carcinoma (OSCC) is inconclusive.
Huang Shiang-Fu, Cheng Sou-De, Chuang Wen-Yu, Chen I-How, Liao Chun-Ta, Wang Hung-Ming, Hsieh Ling-Ling   +6 more
doaj   +1 more source

Prognostic significance of cyclin D1 protein expression and gene amplification in invasive breast carcinoma. [PDF]

PLoS ONE, 2017
The oncogenic capacity of cyclin D1 has long been established in breast cancer. CCND1 amplification has been identified in a subset of patients with poor prognosis, but there are conflicting data regarding the predictive value of cyclin D1 protein ...
Angela B Ortiz, Diego Garcia, Yolanda Vicente, Magda Palka, Carmen Bellas, Paloma Martin   +5 more
doaj   +1 more source

Cyclin D1, Id1 and EMT in breast cancer [PDF]

BMC Cancer, 2011
Abstract Background Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer ...
Andrew H. Sims, Katja L. Lundgren, Göran Landberg, Göran Landberg, Sophie Lehn, Sophie Lehn, Nicholas P. Tobin, Nicholas P. Tobin   +7 more
openaire   +6 more sources

Regulation of cyclin D1 expression and cell cycle progression by mitogen-activated protein kinase cascade [PDF]

, 1999
Regulation of cyclin D1 expression and cell cycle progression by mitogen-activated protein kinase cascade. Mitogen-activated protein kinases (MAPKs) have been shown to play an important role in transducing extracellular signals into cellular responses ...
Inoshita, Seiji, Kuwahara, Michio, Marumo, Fumiaki, Nakashima, Osamu, Sasaki, Sei, Terada, Yoshio   +5 more
core   +1 more source