Results 111 to 120 of about 152,964 (318)

Endogenous cyclin D1 promotes the rate of onset and magnitude of mitogenic signaling via Akt1 Ser473 phosphorylation [PDF]

, 2020
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates RB and functions as a collaborative nuclear oncogene. The serine threonine kinase Akt plays a pivotal role in the control of cellular metabolism, survival, and mitogenic ...
Afonine, Albanese, Albanese, Alessi, Alhaja, Alt, Ashton, Baker, Bienvenu, Bozulic, Casimiro, Casimiro, Casimiro, Chaves, Chen, Choi, Cybulski, Dan, Datta, Di Sante, Di Sante, Dibble, Eves, Finley, Fu, Fusté, Fåhraeus, Gustafsdottir, Halaby, Hay, Hers, Hietakangas, Hresko, Hynes, Ivanschitz, Jiao, Ju, Ju, Kawakami, Kelley, Kim, LaRocca, Lawlor, Li, Li, Li, Li, Liu, Manning, McDonald, Meng, Nebot-Cegarra, Norman, Pestell, Piljic, Potter, Razandi, Rosner, Sabatini, Sakamaki, Sarbassov, Schrodinger, Shen, Sherr, Sicinski, Soutoglou, Ventura, Wang, Wang, Wang, Ward, Yao, Yuan, Zhang, Zhang, Zhong   +75 more
core   +3 more sources

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. [PDF]

PLoS ONE, 2015
Huachansu, a traditional Chinese medicine prepared from the dried toad skin, has been used in clinical studies for various cancers in China. Resibufogenin is a component of huachansu and classified as bufadienolides.
Masami Ichikawa, Yoshihiro Sowa, Yosuke Iizumi, Yuichi Aono, Toshiyuki Sakai   +4 more
doaj   +1 more source

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation [PDF]

Genes & Development, 2000
GSK-3β-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how phosphorylation regulates redistribution has not been resolved. For example, phosphorylation of nuclear cyclin D1 could increase its rate of nuclear export relative to nuclear import ...
Mark Hannink, J. Alan Diehl, Jodi R. Alt, John L. Cleveland   +3 more
openaire   +3 more sources

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells

Neural Development, 2009
Background Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina.
Choi Yoon, Das Gaurav, Sicinski Piotr, Levine Edward M   +3 more
doaj   +1 more source

Down-Regulation of Cyclin D1 Expression by Prostaglandin A2 Is Mediated by Enhanced Cyclin D1 mRNA Turnover [PDF]

Molecular and Cellular Biology, 2000
Prostaglandin A(2) (PGA(2)), an experimental chemotherapeutic agent, causes growth arrest associated with decreased cyclin D1 expression in several cancer cell lines. Here, using human non-small-cell lung carcinoma H1299 cells, we investigated the mechanisms whereby PGA(2) down-regulates cyclin D1 expression.
Myriam Gorospe, Nikki J. Holbrook, Gary Brewer, Gerald M. Wilson, Wengong Wang, Xiaoling Yang, Shankung Lin   +6 more
openaire   +3 more sources

LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5

Advanced Science, EarlyView.
Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li, Zhuo‐Ran Liang, Zhi‐Chao Liu, Xue‐Ping Luo, Jun‐Yi Li, Xiao‐Mei Yu, Xuan‐Zhang Huang, Yan He, Tao‐Yang Xu, Jiao‐Jiao Xu, Shao‐Cong Peng, Yu‐Xiang Song, Yan He, Xiao‐Wan Zhuang, Can‐Can Zheng, Fan Zhang, Alfred King‐Yin Lam, Wei Dai, Ming‐Liang He, Bo Liu, Qi Zhao, Guo‐Liang Lu, Jin‐Bao Liu, Zhen‐Ning Wang, Zhi‐Gang Li, Ze‐Xian Liu, Wen‐Wen Xu, Bin Li   +27 more
wiley   +1 more source

Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels

BMC Cell Biology, 2006
Background The expression level of cyclin D1 plays a vital role in the control of proliferation. This protein is reported to be degraded following phosphorylation by glycogen synthase kinase 3 (GSK3) on Thr-286. We recently showed that phosphorylation of
Hitomi Masahiro, Fretthold Jonathan, Harwalkar Jyoti, Stacey William C, Guo Yang, Yang Ke, Stacey Dennis W   +6 more
doaj   +1 more source

The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

Analytical Cellular Pathology, 2022
Background. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its ...
Yan Shi, Meng-Yan Li, Hui Wang, Chao Li, Wen-Ying Liu, Yong-Mei Gao, Bo Wang, Jia-Wei Song, Yu-Qing Ma   +8 more
doaj   +1 more source