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Cyclin D1-negative mantle cell lymphoma
Human PathologyCyclin D1-negative mantle cell lymphoma (MCL) is regarded as a B-cell neoplasm that has morphologic and immunophenotypic findings indistinguishable from typical MCL. These neoplasms lack cyclin D1 overexpression by immunohistochemistry and t(11;14)(q13;q32)/IGH::CCND1.
Chi Young Ok, L. Jeffrey Medeiros
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Cyclin D1 transcriptional activation in MCL
Blood, 2014In this issue of Blood, Allinne et al propose the nucleolin-dependent activation of the translocated CCND1 allele in mantle cell lymphoma (MCL) because of its relocalization to a transcriptionally favorable area in the perinucleolar region.
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Cyclin D1-negative mantle cell lymphoma
Blood, 2013In this issue of Blood, Salaverria et al report that more than half of Cyclin D1- (CCND1) negative SOX11-positive mantle cell lymphoma (MCL) had CCND2 gene rearrangement predominantly with immunoglobulin (IG) light chain genes.(1)
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2016
Two proto-oncogenes from the Cyclin protein family that are involved in the regulation of the cell cycle are described in this chapter. Cyclin D1 gene or CCND1 is involved in the regulation of the cell cycle and becomes most abundant in the G1 phase in the lead up to DNA replication. The activity of the cyclin D in normal cell physiology contributes to
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Two proto-oncogenes from the Cyclin protein family that are involved in the regulation of the cell cycle are described in this chapter. Cyclin D1 gene or CCND1 is involved in the regulation of the cell cycle and becomes most abundant in the G1 phase in the lead up to DNA replication. The activity of the cyclin D in normal cell physiology contributes to
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Cyclin D1 in Human Neuroendocrine: Tumorigenesis
Annals of the New York Academy of Sciences, 2004Abstract: Human neuroendocrine tumors exhibit unique biological properties, and defining the molecular genetic alterations that underlie these distinctive features remains an important challenge. In addition to the MEN1 tumor suppressor gene, the cyclin D1 oncogene has demonstrated a role in the pathogenesis of parathyroid and gastroenteropancreatic ...
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