Results 171 to 180 of about 3,126,054 (284)

Recent advances of cyclin-dependent kinases as potential therapeutic targets in HR+/HER2− metastatic breast cancer: a focus on ribociclib

, 2017
Dumessa Edessa,1 Mekonnen Sisay2 1Department of Pharmacy Practice, 2Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Oromia, Ethiopia Abstract: In normal cell cycle progression ...
Sisay M, Edessa D
core  

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

Journal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay, Cansu Topkaya, Elif Kağa, Yasin Eren, Ramazan Güp   +4 more
wiley   +1 more source

Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase. [PDF]

Proc Natl Acad Sci U S A
Koyanagi N, Hengphasatporn K, Kato A, Nobe M, Takeshima K, Maruzuru Y, Maenaka K, Shigeta Y, Kawaguchi Y.   +8 more
europepmc   +1 more source

Design, Synthesis, Antitumour Evaluation, and In Silico Studies of Pyrazolo-[1,5-<i>c</i>]quinazolinone Derivatives Targeting Potential Cyclin-Dependent Kinases. [PDF]

Molecules, 2023
Zheng D, Yang C, Li X, Liu D, Wang Y, Wang X, Zhang X, Tan Y, Zhang Y, Li Y, Xu J.   +10 more
europepmc   +1 more source

Cytotoxic and Pro‐Apoptotic Effects of the Compound 2‐Carboxy‐2‐Heptano‐Indolin‐3‐One in HeLa Cell Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Indolinones are compounds with recognized antineoplastic properties and can act as inhibitors of multiple kinases. However, the antitumor effects of 2‐carboxy‐2‐heptano‐indolin‐3‐one (IDC) have not yet been investigated in cervical cancer models.
Agda Lorena Corrêa Rocha, Caroline Fernandes Westin, Erika Tyemi Goya Niekawa, Galdino Andrade, Luan Vitor Alves de Lima, Lucas Karpinski Risson, Matheus Felipe da Silva, Stefani Fabiola Alarcon, Mário Sérgio Mantovani   +8 more
wiley   +1 more source

Differential activity of specific inhibitors of transcription regulating cyclin-dependent kinases in thyroid cancer cells. [PDF]

Endocr Relat Cancer
Rajan N, Khanal T, Adik A, Valenciaga A, Nigam A, Liyanarachchi S, Ringel MD.   +6 more
europepmc   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Efficacy of cyclin-dependent kinases 4 and 6 inhibitors in the treatment of HR +/HER2 - advanced breast cancer: a meta-analysis. [PDF]

Eur J Med Res
Danbala IA, Wang X, Su Y, Tang H, Sheng W, Shaibu Z, Isah I, Yuan X.   +7 more
europepmc   +1 more source

Clinicopathological value of the upregulation of cyclin-dependent kinases regulatory subunit 2 in osteosarcoma. [PDF]

BMC Med Genomics, 2022
Mo C, Wu Y, Ma J, Xie L, Huang Y, Xu Y, Peng H, Chen Z, Zeng M, Mao R.   +9 more
europepmc   +1 more source

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma

The Laryngoscope, EarlyView.
We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano, Satoshi Kiyama, Takayuki Kyutoku, Masaru Yamashita   +3 more
wiley   +1 more source