Results 91 to 100 of about 50,602 (189)
The regulation of cyclin D promoters – review
Cancer Treatment and Research Communications, 2021 Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery ...
Jan Pawlonka +2 more
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Translational Oncogenomics and Human Cancer Interactome Networks [PDF]
, 2011 An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology.
I. C. Baianu
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SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities [PDF]
, 1997 Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 proteolysis is mediated by the ubiquitin pathway and requires the action of CDC34 ...
Deshaies, Raymond J. +2 more
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mBio, 2017 All well-studied eukaryotic cell cycles are driven by cyclins, which activate cyclin-dependent kinases (CDKs), and these protein kinase complexes are viable drug targets.
Jonathan A. Robbins +3 more
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Coordinated synthesis of the nuclear protein cyclin and DNA in serum‐stimulated quiescent 3T3 cells [PDF]
, 1984 R Bravo
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Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes. [PDF]
, 1987 Pekka Kurki +3 more
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The Molecular Perspective: Cyclins
STEM CELLS, 2004 Abstract Learning Objective After completing this course, the reader will be able to: Describe the role of cyclins and cyclin-dependent kinases in cancer. Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com
openaire +4 more sources
Expression Dynamics and Genetic Compensation of Cell Cycle Paralogues in Saccharomyces cerevisiae
CellsCell cycle progression of the yeast Saccharomyces cerevisiae is largely driven by the expression of cyclins, which in turn bind the cyclin-dependent kinase CDK1 providing specificity.
Gabriele Schreiber +5 more
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PLoS Genetics, 2014 Loss of function of cyclin E1 or E2, important regulators of the mitotic cell cycle, yields viable mice, but E2-deficient males display reduced fertility.
Laetitia Martinerie +8 more
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A Novel Role of Cdk9/CyclinT2 complexes in skeletal muscle and Rhabdomyosarcoma cells [PDF]
, 2010 Cyclin dependent kinase 9 (Cdk9) is a member of the cyclin dependent kinase family. The regulatory units of Cdk9 are the T family Cyclins (T1, T2) and Cyclin K1.
Marchesi, Irene
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