Results 1 to 10 of about 2,503 (50)

A study towards the synthesis of (-)-atrop-abyssomicin C core [PDF]

open access: yesJournal of the Serbian Chemical Society, 2021
An attempt to synthesize the cyclohexane core of antibiotic abyssomicin C is described. The initial, protecting group-free approach (relying on internal protection) failed and had to be modified, in order to allow for efficient deprotection of the acid ...
Saičić Radomir N., Trmčić Milena
doaj   +1 more source

Applications of transition state calculations in the key cyclization of small molecule natural product synthesis [PDF]

open access: yesE3S Web of Conferences, 2021
The diversification of the conformation and configuration of the carbocyclic skeleton of natural products is an important reason for the diversity and complexity of the structure of natural products.
Qiu Rongxiang
doaj   +1 more source

Influence of Monomer Sequence on the Cyclization Behavior of Poly(acrylonitrile-co-acrylamide)

open access: yesApplied Sciences, 2023
In this research, we have developed the approach to controlled synthesis of acrylonitrile-acrylamide copolymers with narrow molecular weight distribution and various monomer sequence distributions.
Roman V. Toms   +5 more
doaj   +1 more source

Efficient Synthesis of Isoquinoline Derivatives through Sequential Cyclization–Deoxygenation Reaction of 2-Alkynylbenzaldoximes

open access: yesSynOpen, 2022
We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi   +5 more
doaj   +1 more source

Oxidative Cyclization at ortho-Position of Phenol: Improved Total Synthesis of 3-(Phenethylamino)demethyl(oxy)aaptamine

open access: yesMarine Drugs, 2023
A shorter synthesis of the demethyl(oxy)aaptamine skeleton was developed via oxidative intramolecular cyclization of 1-(2-azidoethyl)-6-methoxyisoquinolin-7-ol followed by dehydrogenation with a hypervalent iodine reagent.
Yuki Nakatani   +3 more
doaj   +1 more source

Unified short syntheses of oxygenated tricyclic aromatic diterpenes by radical cyclization with a photoredox catalyst

open access: yesCommunications Chemistry, 2023
The biomimetic two-phase strategy employing polyene cyclization and subsequent oxidation/substitution is an effective approach for divergent syntheses of [6-6-6]-tricyclic diterpenes.
Riichi Hashimoto   +3 more
doaj   +1 more source

Urine Metabolite Profiling of Human Colorectal Cancer by Capillary Electrophoresis Mass Spectrometry Based on MRB

open access: yesGastroenterology Research and Practice, 2012
Aim. The study was to investigate the metabolic profile of urine metabolites and to elucidate their clinical significance in patients with colorectal cancer. Methods. Colorectal cancers from early stage and advanced stage were used in this study.
Jin-Lian Chen   +6 more
doaj   +1 more source

Cyclization mechanism and kinetics of poly(acrylonitrile-co-2-acrylamido-2-methylpropane sulfonic acid) copolymer investigated by FTIR spectroscopy

open access: yesPolymer Testing, 2021
Cyclization reaction of poly(acrylonitrile-co-2-acrylamido-2-methylpropane sulfonic acid) [P(AN-co-AMPS)] copolymer during thermal oxidative stabilization (TOS) process was investigated by FTIR and two dimensional (2D) correlation analysis technique. The
Zhipeng He   +8 more
doaj  

CYCLIZATION AND HYDROGENATION OF (+)-CITRONELLAL TO MENTHOLS OVER ZnBr2 AND Ni CATALYSTS SUPPORTED ON γ-Al2O3

open access: yesIndonesian Journal of Chemistry, 2010
Two steps transformation of (+)-citronellal, cyclization and hydrogenation, on ZnBr2/γ-Al2O3 and Ni/γ-Al2O3 catalyst have been realized with the selectivity to cyclization products (isopulegols) was very high (yield up to ~92.58%) over ZnBr2/γ-Al2O3 ...
Elvina Dhiaul Iftitah   +3 more
doaj   +1 more source

Harnessing the cyclization strategy for new drug discovery

open access: yesActa Pharmaceutica Sinica B, 2022
The design of new ligands with high affinity and specificity against the targets of interest has been a central focus in drug discovery. As one of the most commonly used methods in drug discovery, the cyclization represents a feasible strategy to ...
Kai Tang   +4 more
doaj  

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