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ELECTROPHILIC CYCLIZATION OF DITERPENOIDS [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2006 A review of diterpenoid cyclization initiated by electrophilic reagents is provided. Conventional protonic and Lewis acids are examined along with superacids as initiators of cyclization cascade.
Veaceslav Kulciţki +3 more
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A study towards the synthesis of (-)-atrop-abyssomicin C core [PDF]
Journal of the Serbian Chemical Society, 2021 An attempt to synthesize the cyclohexane core of antibiotic abyssomicin C is described. The initial, protecting group-free approach (relying on internal protection) failed and had to be modified, in order to allow for efficient deprotection of the acid ...
Saičić Radomir N., Trmčić Milena
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Applications of transition state calculations in the key cyclization of small molecule natural product synthesis [PDF]
E3S Web of Conferences, 2021 The diversification of the conformation and configuration of the carbocyclic skeleton of natural products is an important reason for the diversity and complexity of the structure of natural products.
Qiu Rongxiang
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Nature Chemical Biology, 2008 The berberine bridge enzyme catalyzes the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism that couples two distinct chemical steps-oxidation and proton abstraction-affecting two ...
FRAAIJE MW, MATTEVI, ANDREA
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To Cyclize or Not To Cyclize: Catching Enzyme Evolution in the Act [PDF]
ACS Chemical Biology, 2009 If you look at the biggest genes in soil and marine bacteria, you tend to see the chemical blueprints for making natural products such as peptides and polyketides. Over the past decade, collective efforts of enzymologists working with synthetic and analytical chemists have been catching up with the data dump from microbial genome sequencing.
Bradley S. Evans, Neil L. Kelleher
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Influence of Monomer Sequence on the Cyclization Behavior of Poly(acrylonitrile-co-acrylamide)
Applied Sciences, 2023 In this research, we have developed the approach to controlled synthesis of acrylonitrile-acrylamide copolymers with narrow molecular weight distribution and various monomer sequence distributions.
Roman V. Toms +5 more
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The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]
, 2017 Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna +3 more
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SynOpen, 2022 We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi +5 more
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Cyclization-activated Prodrugs [PDF]
Molecules, 2007 Many drugs suffer from an extensive first-pass metabolism leading to druginactivation and/or production of toxic metabolites, which makes them attractive targets forprodrug design. The classical prodrug approach, which involves enzyme-sensitive covalentlinkage between the parent drug and a carrier moiety, is a well established strategy toovercome ...
Paula Gomes, Nuno Vale, Rui Moreira
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Marine Drugs, 2023 A shorter synthesis of the demethyl(oxy)aaptamine skeleton was developed via oxidative intramolecular cyclization of 1-(2-azidoethyl)-6-methoxyisoquinolin-7-ol followed by dehydrogenation with a hypervalent iodine reagent.
Yuki Nakatani +3 more
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