Results 11 to 20 of about 2,874,801 (150)
Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization
Journal of Natural Products, 2020 The chemical reactivity of cannabidiol is based on its ability to undergo intramolecular cyclization driven by the addition of a phenolic group to one of its two double bonds.
Paola Marzullo +7 more
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Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
Science, 2019 Light teaches (co)enzymes new tricks Light is widely used in organic synthesis to excite electrons in a substrate or catalyst, opening up reactive pathways to a desired product.
Kyle F. Biegasiewicz +9 more
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Oxidative Cyclization in Natural Product Biosynthesis.
Chemical Reviews, 2017 Oxidative cyclizations are important transformations that occur widely during natural product biosynthesis. The transformations from acyclic precursors to cyclized products can afford morphed scaffolds, structural rigidity, and biological activities ...
Mancheng Tang +4 more
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Asymmetric Redox-Neutral Radical Cyclization Catalyzed by Flavin-Dependent ‘Ene’-Reductases
Nature Chemistry, 2019 Flavin-dependent ‘ene’-reductases (EREDs) are exquisite catalysts for effecting stereoselective reductions. Although these reactions typically proceed through a hydride transfer mechanism, we recently found that EREDs can also catalyse reductive ...
M. Black +6 more
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Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides.
Journal of the American Chemical Society, 2019 Cyclic peptides are drawing wide attentions as potential medium-sized modulators of biomolecular interactions with large binding surfaces. Simple but effective peptide cyclization methods are needed to construct cyclic peptide libraries by both peptide ...
Yue Zhang +3 more
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Beilstein Journal of Organic Chemistry, 2021 A facile synthesis of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridine derivatives is reported which is based on POCl3-mediated cyclodehydration followed by double Suzuki–Miyaura cross-coupling.
Najeh Tka +4 more
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Enzymatic Bromocyclization of α‐ and γ‐Allenols by Chloroperoxidase from Curvularia inaequalis
ChemistryOpen, 2022 Vanadate‐dependent chloroperoxidase from Curvularia inaequalis catalyzes 5‐endo‐trig bromocyclizations of α‐allenols to produce valuable halofunctionalized furans as versatile synthetic building blocks. In contrast to other haloperoxidases, also the more
Janne M. Naapuri +3 more
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Journal of the American Chemical Society, 2018 Radical cyclization represents a powerful strategy for construction of ring structures. Traditional radical cyclization, which is based on radical addition as the key step, necessitates the use of unsaturated substrates.
Yong Wang, X. Wen, X. Cui, X. Zhang
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Frontiers in Chemistry, 2015 Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function.
Frank H Schumann +6 more
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Anodic Cyclization Reactions and the Mechanistic Strategies That Enable Optimization.
Accounts of Chemical Research, 2017 Oxidation reactions are powerful tools for synthesis because they allow us to reverse the polarity of electron-rich functional groups, generate highly reactive intermediates, and increase the functionality of molecules.
Ruozhu Feng, Jake A. Smith, K. Moeller
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