Results 11 to 20 of about 3,707,282 (391)
ELECTROPHILIC CYCLIZATION OF DITERPENOIDS [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2006 A review of diterpenoid cyclization initiated by electrophilic reagents is provided. Conventional protonic and Lewis acids are examined along with superacids as initiators of cyclization cascade.
Veaceslav Kulciţki +3 more
doaj +3 more sources
Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals
Nature Chemistry, 2017 The rapid generation of molecular complexity from simple starting materials is a key challenge in synthesis. Enantioselective radical cyclization cascades have the potential to deliver complex, densely packed, polycyclic architectures, with control of three-dimensional shape, in one step.
Nicolas Kern +3 more
semanticscholar +6 more sources
Nature Chemical Biology, 2008 The berberine bridge enzyme catalyzes the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism that couples two distinct chemical steps-oxidation and proton abstraction-affecting two ...
FRAAIJE MW, MATTEVI, ANDREA
openaire +3 more sources
To Cyclize or Not To Cyclize: Catching Enzyme Evolution in the Act [PDF]
ACS Chemical Biology, 2009 If you look at the biggest genes in soil and marine bacteria, you tend to see the chemical blueprints for making natural products such as peptides and polyketides. Over the past decade, collective efforts of enzymologists working with synthetic and analytical chemists have been catching up with the data dump from microbial genome sequencing.
Bradley S. Evans, Neil L. Kelleher
openaire +3 more sources
Cyclization-activated Prodrugs [PDF]
Molecules, 2007 Many drugs suffer from an extensive first-pass metabolism leading to druginactivation and/or production of toxic metabolites, which makes them attractive targets forprodrug design. The classical prodrug approach, which involves enzyme-sensitive covalentlinkage between the parent drug and a carrier moiety, is a well established strategy toovercome ...
Paula Gomes, Nuno Vale, Rui Moreira
openaire +5 more sources
Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies [PDF]
, 2011 Radical cyclization reactions were performed by 5-exo-dig mode to yield cis-fused bicyclic systems, leading to the synthesis of bis-butyrolactone class of natural products.
Allinger +23 more
core +1 more source
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]
, 2017 Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna +3 more
core +2 more sources
Iodoarene-Catalyzed Cyclizations of Unsaturated Amides [PDF]
, 2015 The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route.
Ali Alhalib +30 more
core +1 more source
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
Science, 2019 Light teaches (co)enzymes new tricks Light is widely used in organic synthesis to excite electrons in a substrate or catalyst, opening up reactive pathways to a desired product.
Kyle F. Biegasiewicz +9 more
semanticscholar +1 more source
Carbocations and the Complex Flavor and Bouquet of Wine: Mechanistic Aspects of Terpene Biosynthesis in Wine Grapes. [PDF]
, 2015 Computational chemistry approaches for studying the formation of terpenes/terpenoids in wines are presented, using five particular terpenes/terpenoids (1,8-cineole, α-ylangene, botrydial, rotundone, and the wine lactone), volatile compounds (or their ...
Pemberton, Ryan P +2 more
core +2 more sources