Results 51 to 60 of about 3,998 (209)

The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis

Angewandte Chemie International Edition, EarlyView.
Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio, René Slot Bitsch, Karl Anker Jørgensen   +2 more
wiley   +1 more source

Enantioselective synthesis of cyclobutylboronates via a copper-catalyzed desymmetrization approach [PDF]

, 2016
This is the peer reviewed version of the following article: Guisán-Ceinos, M., Parra, A., Martín-Heras, V. and Tortosa, M. (2016), Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach. Angew. Chem., which has
Guisán-Ceinos, M., Martín-Heras, Víctor, Parra, A., Tortosa Manzanares, Mariola   +3 more
core   +2 more sources

Cyclobutanes in Small‐Molecule Drug Candidates

ChemMedChem, 2022
AbstractCyclobutanes are increasingly used in medicinal chemistry in the search for relevant biological properties. Important characteristics of the cyclobutane ring include its unique puckered structure, longer C−C bond lengths, increased C−C π‐character and relative chemical inertness for a highly strained carbocycle.
Marnix R. van der Kolk, Mathilde A. C. H. Janssen, Floris P. J. T. Rutjes, Daniel Blanco‐Ania   +3 more
openaire   +4 more sources

Methyl on the Bridge: 2‐Methyl Propellane as Precursor for 1,3‐Substituted 2‐Methylated Bicyclo[1.1.1]Pentanes

Chemistry – A European Journal, EarlyView.
The synthesis of 2‐methyl propellane and its conversion to various 1,2‐ and 1,2,3‐di‐ and trisubstituted bicyclopentanes is reported. Abstract Bicyclo[1.1.1]pentanes (BCPs) have emerged as isosteric replacements for mono‐ and para‐substituted benzene rings in medicinal and materials applications, involving substitution at the BCP bridgehead (1,3 ...
Sean R. Verschaeve, Mariana Gomes Manso, Tibo Van Eeckhoorn, Mark E. Light, Bruno Linclau   +4 more
wiley   +1 more source

[2+2]-Photocycloadditions of 2-Acetoxy-1,4-naphthoquinone and Structure Determination of the Main Photoadducts

Photochem
The [2+2]-photocycloaddition of 2-acetoxy-1,4-naphthoquinone with 1,1-diphenylethylene, styrene and cyclopentene was conducted in a conventional batch reactor.
Madyan A. Yaseen, Zhifang Guo, Peter C. Junk, Michael Oelgemöller   +3 more
doaj   +1 more source

Light‐Induced Reactions of Small‐Membered Cyclic Carbonyl Compounds

European Journal of Organic Chemistry, EarlyView.
This review highlights recent advances in the synthesis and photochemical reactivity of cyclopropenone and cyclobutenedione. These compounds undergo photolysis upon direct excitation, and in some cases, through indirect excitation by photocatalysts. The resulting photogenerated species exhibit unique reactivity profiles that are strongly influenced by ...
Kenji Mishiro
wiley   +1 more source

Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane

Helvetica Chimica Acta, EarlyView.
We report a concise formal synthesis of (±)‐strictamine via a silylium‐catalyzed (4 + 2) annulation of a donor–acceptor cyclobutane, achieved in 13 steps from tryptamine. ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities.
Clément Tanguy, Emma G. L. Robert, Jerome Waser   +2 more
wiley   +1 more source

Intermolecular Enantioselective Nickel-Catalyzed Arylation of Un-Activated C(sp³)─H Bond. [PDF]

Angew Chem Int Ed Engl
Ni: a new solution for asymmetric C(sp3)─H activation. The stereoselective synthesis of all‐carbon quaternary stereogenic centres is achieved via enantioselective C(sp3)─H arylation using a Ni‐BINOL‐derived catalyst. Rational catalytic cycle design uncovers a new reaction pathway that can efficiently induce chiral information during the stereoselective
Brunard E, Huang F, Díaz-Jiménez À, Kostiukovska S, Wencel-Delord J.   +4 more
europepmc   +2 more sources

The Synthesis and Testing of Highly Strained Cyclic and Polycyclic Molecules as Hypergolic Fuels [PDF]

, 2005
Increasing fuel efficiency has been a goal for chemists for several decades. Particularly, a more efficient fuel can increase the range of liquid-hydrocarbon-fueled ram-jets and cruise missiles. A storable high-energy fuel that spontaneously ignites upon
Eccles, Wendy
core   +1 more source

An unexpected Ireland–Claisen rearrangement cascade during the synthesis of the tricyclic core of Curcusone C: Mechanistic elucidation by trial-and-error and automatic artificial force-induced reaction (AFIR) computations [PDF]

, 2019
In the course of a total synthesis effort directed toward the natural product curcusone C, the Stoltz group discovered an unexpected thermal rearrangement of a divinylcyclopropane to the product of a formal Cope/1,3-sigmatropic shift sequence.
Houk, K. N., Lee, Chung Whan, Morokuma, Keiji, Patel, Ashay, Petrova, Galina P., Stoltz, Brian M., Taylor, Buck L. H.   +6 more
core   +5 more sources