Results 71 to 80 of about 3,998 (209)

Interventional human ocular safety experiments for 222‐nm far‐ultraviolet‐C lamp irradiation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 517-526, March/April 2025.
To directly assess the ocular safety of 222‐nm far‐ultraviolet‐C (UVC) irradiation in humans, five subjects were exposed to 222‐nm UVC at doses of 22, 50, and 75 mJ/cm2. The findings indicate that far‐UVC irradiation does not cause “clinically significant photokeratitis” or long‐term ocular damage, though it may induce temporary discomfort.
Kazunobu Sugihara, Sachiko Kaidzu, Masahiro Sasaki, Masaki Tanito   +3 more
wiley   +1 more source

Effect of C5-Methylation of Cytosine on the UV-Induced Reactivity of Duplex DNA: Conformational and Electronic Factors [PDF]

, 2016
International audienceC5-methylation of cytosines is strongly correlated with UV-induced mutations detected in skin cancers. Mutational hot-spots appearing at TCG sites are due to the formation of pyrimidine cyclobutane dimers (CPDs).
Banyasz, Akos, Douki, Thierry, Esposito, Luciana, Improta, Roberto, Lepori, Clément, Markovitsi, Dimitra, Perron, Marion   +6 more
core   +3 more sources

Spectroscopic analysis of bacterial photoreactivation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 494-504, March/April 2025.
This study investigates the effectiveness of fluorescence and Raman spectroscopy in detecting bacterial photoreactivation. Fluorescence spectroscopy shows limitations, because the intense fluorescence of tryptophan and tyrosine masks fluorescence emitted by thymine molecules.
Keyvan Khosh Abady, Negar Karpourazar, Arjun Krishnamoorthi, Runze Li, Peter M. Rentzepis   +4 more
wiley   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides [PDF]

, 2019
Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to ...
Adada, Baeyer, Borowiak, Chiantia, D'Angelo, Eisenbraun, Feng, Frank, Frank, Frank, Gaebler, Garner, Garner, Haberkant, Hannun, Holthuis, Honigmann, Huitema, Höglinger, Höglinger, Jain, Kim, Kol, Koval, Leinders-Zufall, Li, Li, Liu, MacHin, McIntosh, Meikle, Mills, Mitsutake, Müller, Nishioka, Ogretmen, Ohira, Ojima, Oppolzer, Park, Peters, Priewisch, Rai, Seike, Sivakumar, Slotte, Strueben, Tafesse, Thiele, Wegner, Yamaoka, Yamashita   +51 more
core   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Enantioselective dearomative ortho-cycloaddition transformation of unactivated arenes by cage-confined visible-light photocatalysis

Nature Communications
Photoinduced dearomatization of arenes is a powerful strategy in organic synthesis to disrupt the stable aromaticity; however, the asymmetric dearomatization photocatalysis of unactivated arenes remains highly challenging and rare.
Jie Yang, Zhongshu Li, Xiantao Wu, Jie Chen, Sisi Huang, Yu-Lin Lu, Zhiwei Jiao, Cheng-Yong Su   +7 more
doaj   +1 more source

Diastereoselective Synthesis of C60/Steroid Conjugates [PDF]

, 2013
The design and synthesis of fullerene–steroid hybrids by using Prato’s protocol has afforded new fullerene derivatives endowed with epiandrosterone, an important naturally occurring steroid hormone.
Ajamaa F., Alberto Ruiz, An Y., Beck M. T., Bjelakovic M. S., Campidelli S., Coro J., Da Ros T., Dolores Molero, Doss S. H., Echegoyen L. E., Eliel E. L., Enrique E. Maroto, Filippone S., Florent Di Meo, Fong R., Grimme S. J., Grimme S. J., Grimme S. J., Guldi D. M., Gupte S. A., Hirsch A., Illescas B., Illescas B. M., Ioutsi V. A., Ishi-I T., Itoh T., José A. Ruiz, Juan Carlos Sancho-García, Julieta Coro, Li L., Luis Almagro, Maggini M., Margarita Suárez, Maroto E., Maroto E. E., Maroto E. E., Martín N., Martín N., María Ángeles Herranz, Merlani M. I., Nazario Martín, Neese F., Novello F., Pantarotto D., Prato M., Raeside J. I., Reyes-Moreno M., Reyes-Moreno M., Roberto Martínez-Álvarez, Salvatore Filippone, Sawai K., Schuster D. I., Schwabe T., Tan X., Wilson S. R.   +55 more
core   +2 more sources

Germicidal potential and skin compatibility of an innovative UVC phototherapy device emitting at 234 nm

Photochemistry and Photobiology, EarlyView.
A phototherapy device emitting principally at 234 nm was assessed for antimicrobial efficacy against Methicillin‐resistant Staphylococcus aureus and evaluated for skin health hazards. Abstract Chronic wounds are a major healthcare issue affecting more than 10 million Americans each year, with a 5‐year survival similar to cancer and costing the ...
Zheng Tang, David Welch, Manuela Buonanno, Mark Gerber, David J. Brenner   +4 more
wiley   +1 more source

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines [PDF]

, 2015
Described in this work is a novel method for photochemically manipulating peptides and proteins via the installation of cysteine-selective photoactive tags.
Baker, JR, Chudasama, V, Fletcher, SA, Kossen, H, Nobles, M, Richards, DA, Tedaldi, L, Tinker, A   +7 more
core