Results 111 to 120 of about 577 (161)

Filaricidal efficacy of anthelmintically active cyclodepsipeptides

International Journal for Parasitology, 2001
PF 1022A, a novel anthelmintically active cyclodepsipeptide, and Bay 44-4400, a semisynthetic derivative of PF 1022A were tested for filaricidal efficacy in Mastomys coucha infected with Litomosoides sigmodontis, Acanthocheilonema viteae and Brugia malayi. The parent compound PF 1022A showed limited anti-filarial efficacy in L.
Horst Zahner, Anja Taubert, Achim Harder   +2 more
exaly   +3 more sources

Cyclols, cyclodepsipeptides, and N‐acyl‐diketopiperazines from linear precursors: Synthesis and crystal structure of 10‐membered cyclodepsipeptides

International Journal of Peptide and Protein Research, 1983
In order to investigate the relative formation tendency of different tautomeric ring systems (cyclols, cyclodepsipeptides and corresponding N ‐acyl‐diketopiperazines), two linear peptide precursors containing proline as C ‐terminal residue, have been synthesized and subjected to cyclizing conditions.
Giancarlo Zanotti, F Pinnen, G Lucente   +2 more
exaly   +3 more sources

Synthetic Route to the GE3 Cyclodepsipeptide.

ChemInform, 2002
[reaction: see text] A reasonably efficient [2 + 2 + 2] fragment condensation strategy has been developed for assembling the cyclodepsipeptide sector of GE3 that involves 5-7. A Carpino HATU-mediated macrolactamization was used to close the 19-membered cyclodepsipeptide ring.
Karl J, Hale, Linos, Lazarides
openaire   +2 more sources

Synthesis of Cyclodepsipeptides by Cyclooligomerization

Angewandte Chemie International Edition in English, 1977
The antibiotic valinomycin is a cyclic depsipeptide of formula (2), n=3. All cyclodepsipeptides (2) can be prepared by cyclooligomerization of the linear subunits of type (1) in toulene or diethyl phosphite. equation image
Manfred Rothe, Wolfgang Kreiss
openaire   +1 more source

Chimeric Cyclodepsipeptides as Mimetics for the Anthelmintic PF1022A.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Hubert, Dyker, Achim, Harder, Jürgen, Scherkenbeck   +2 more
openaire   +2 more sources

Restricted Conformation Analogues of an Anthelmintic Cyclodepsipeptide

Journal of Medicinal Chemistry, 2003
Six analogues of the anthelmintic cyclodepsipeptide PF1022A were prepared, each containing a small ring fused to the macrocycle to restrict the number of conformations the larger ring can adopt. It was anticipated that such conformational changes could lead to enhanced biological activity and selectivity.
Fred E, Dutton, Byung H, Lee, Sandra S, Johnson, Eileen M, Coscarelli, Pil H, Lee   +4 more
openaire   +2 more sources

Solid-Phase Synthesis of a Cyclodepsipeptide: Cotransin

Organic Letters, 2008
The first solid-phase synthesis of cotransin--a cyclic depsipeptide having high pharmacological potential--was achieved, by a proper choice of coupling reagents and use of either TBAF or DBU for Fmoc removal to suppress the otherwise dominating, sequence-derived diketopiperazine formation.
Irene, Coin, Monika, Beerbaum, Peter, Schmieder, Michael, Bienert, Michael, Beyermann   +4 more
openaire   +2 more sources

The monamycins, a new family of cyclodepsipeptide antibiotics

Experientia, 1970
Die Analyse von Monamycin, einem Antibiotika-Komplex, fuhrte zur Identifizierung der 15 Cyclohexadepsipeptidkomponenten. Fur Monamycin D1 wurde Strukturformel V abgeleitet.
K, Bevan, J S, Davies, M J, Hall, C H, Hassall, R B, Morton, D A, Phillips, Y, Ogihara, W A, Thomas   +7 more
openaire   +2 more sources

Total Synthesis and Structural Determination of Cyclodepsipeptide Decatransin

Organic Letters, 2022
The structure determination of the 30-membered cyclodepsipeptide decatransin was demonstrated on the basis of total synthesis. Both (R)- and (S)-2-hydroxy-5-methylhexanoic acid derivatives were prepared via the Evans asymmetric alkylation. N-Alkyl-enriched peptide fragments were synthesized by the Cbz strategy in the solution phase without formation of
Kosuke Ohsawa, Sakiko Fukaya, Takayuki Doi   +2 more
openaire   +2 more sources

Total Synthesis and Biosynthesis of Cyclodepsipeptide Cochinmicin I

Organic Letters, 2022
Phenylglycines are building blocks of many non-ribosomally synthesized peptides. The dihydroxyphenylglycine-containing cyclodepsipeptide cochinmicin I exhibits endothelin receptor antagonist activity. Therefore, it represents an interesting and synthetically challenging molecule because of the racemization-prone nature of dihydroxyphenylglycine.
Romina Schnegotzki, Vincent Wiebach, Marina Sánchez-Hidalgo, Marcel Tietzmann, Andreas B. zur Bonsen, Olga Genilloud, Roderich D. Süssmuth   +6 more
openaire   +2 more sources