Results 121 to 130 of about 577 (161)

Cyclodepsipeptid‐Synthese durch Cyclooligomerisierung

Angewandte Chemie, 1977
Das Antibioticum Valinomycin ist ein cyclisches Depsipeptid der Formel (2), n=3. Durch Cyclooligomerisierung der linearen Untereinheiten vom Typ (1) in Toluol oder Diethylphosphit lassen sich alle Cyclodepsipeptide (2) darstellen.magnified ...
Manfred Rothe, Wolfgang Kreiß
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An Overview of the Synthesis of Biologically Active Cyclodepsipeptides

ChemistrySelect, 2022
Abstract Cyclodepsipeptide are a class of natural cyclic peptides that have a wide range of biological activities, hence the potential to be developed as new drug candidates. Cyclodpesipeptides comprise a backbone of amide bonds and at least one ester moiety, thus are complex and challenging to synthesis ...
Harra Ismi Farah, Unang Supratman, Ace Tatang Hidayat, Rani Maharani   +3 more
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Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide

Journal of Natural Products, 2020
Calcium homeostasis is implicated in some cancers, leading to the possibility that selective control of calcium might lead to new cancer drugs. On the basis of this idea, we designed an assay using a glioblastoma cell line and screened a collection of 1000 unique bacterial extracts.
Joshua P. Torres, Zhenjian Lin, David S. Fenton, Lee U. Leavitt, Changshan Niu, Pui-Ying Lam, Jose Miguel Robes, Randall T. Peterson, Gisela P. Concepcion, Margo G. Haygood, Baldomero M. Olivera, Eric W. Schmidt   +11 more
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PF1022A and Related Cyclodepsipeptides - A Novel Class of Anthelmintics

Current Topics in Medicinal Chemistry, 2002
Parasitic nematodes are a major cause of morbidity and mortality in man and also cause widespread loss of food production by infection of livestock. A milestone in the chemotherapy of nematode infections, especially in animals, was the discovery of the avermectins and milbemycins during the 1970s.
Jurgen, Scherkenbeck, Peter, Jeschke, Achim, Harder   +2 more
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Insecticidal Cyclodepsipeptides from Beauveria felina

Journal of Natural Products, 2011
A novel cyclodepsipeptide, iso-isariin B (1), and the known isaridin E (2) were isolated from the entomopathogenic fungus Beauveria felina. Their structures were elucidated using MS/MS fragmentation and extensive 2D-heteronuclear NMR. The X-ray structure of isaridin E was obtained, showing two potent intramolecular H bonds and a type-VI turn with the ...
Aude, Langenfeld, Alain, Blond, Sabelle, Gueye, Patrick, Herson, Bastien, Nay, Joëlle, Dupont, Soizic, Prado   +6 more
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Synthesis of complex head-to-side-chain cyclodepsipeptides

Nature Protocols, 2016
Cyclodepsipeptides are cyclic peptides in which at least one amide link on the backbone is replaced with an ester link. These natural products present a high structural diversity that corresponds to a broad range of biological activities. Therefore, they are very promising pharmaceutical candidates.
Marta, Pelay-Gimeno, Fernando, Albericio, Judit, Tulla-Puche   +2 more
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A Novel Cyclodepsipeptide, HA23, from a Fusarium sp.

Organic Letters, 2002
[reaction: see text] HA 23, a novel cyclodepsipeptide (1) of mixed peptide-polyketide origins, was isolated from a fungal isolate of a Fusarium sp. The structure was determined from 1D and 2D NMR and mass spectral data.
Feng, YJ, Blunt, JW, Cole, ALJ, Munro, MHG   +3 more
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Serine‐containing 10‐membered cyclodepsipeptides

International Journal of Peptide and Protein Research, 1993
As a part of a Research program aimed at studying synthesis and conformation of small ring peptides, the cyclization of diastereoisomeric N‐phenylacetyl‐seryl‐propyl‐proline tripeptides has been examined. Two 10‐ membered peptide lactones, and , have been isolated by treating the corresponding linear p‐nitrophenyl esters with DBU in dry benzene.
S. CERRINI, E. GAVUZZO, G. LUIS, F. PINNEN   +3 more
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Total synthesis of the cyclodepsipeptide ionophore pithomycolide

Tetrahedron Letters, 1996
Abstract The total synthesis of pithomycolide 1 , a structurally unique ionophoric depsipeptide from the fungus Pithomyces chartarum , is described.
Magdi M. Moussa, Philip W. Le Quesne
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Insecticidal cyclodepsipeptides from Metarhizium anisopliae

Journal of the Chemical Society, Perkin Transactions 1, 1989
Bioassay-guided fractionation of the culture broth of Metarhizium anisopliae resulted in the isolation of 10 insecticidal cyclodepsipeptides–the destruxins, including two new compounds, destruxin E2 and chlorohydrin. Complete 1H and 13C n.m.r. assignments for the major destruxins, A and B, by various 1 D and 2D n.m.r.
Gupta, Sandeep, Roberts, Donald W., Renwick, J. A. A.   +2 more
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