Results 11 to 20 of about 236,794 (382)
Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes [PDF]
Molecules, 2018 Cyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound together in a ring, show a promising ability to form complexes with drug molecules and improve their physicochemical properties without molecular modifications. The stoichiometry of drug/CD complexes is most frequently 1:1.
Phennapha Saokham +3 more
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Sulfobutylether-β-cyclodextrin
International Journal of Pharmaceutics, 2020 This review presents the early history, the motivation, the research and some of the backstories behind the discovery and development of sulfobutylether-β-cyclodextrin as a novel parenterally safe solubilizer and stabilizer. A specific sulfobutylether-β-cyclodextrin with an average degree of 6.5 sulfobutyl-groups variably substituted on the 2-, 3- and ...
Stella, Valentino J., Rajewski, Roger A.
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Pharmaceutics, 2023 Many active pharmaceutical ingredients show low oral bioavailability due to factors such as poor solubility and physical and chemical instability.
Álvaro Sarabia-Vallejo +4 more
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Recent List of Cyclodextrin-Containing Drug Products
Periodica Polytechnica: Chemical Engineering, 2023 The number of the cyclodextrin-containing drug formulations on the market has been continuously growing since the first drug (prostaglandin E1 formulated with α-cyclodextrin) was launched in Japan in 1976.
I. Puskás +3 more
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Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery
Nature Nanotechnology, 2023 Although cyclodextrin-based renal-clearable nanocarriers have a high potential for clinical translation in targeted cancer therapy, their designs remain to be optimized for tumour retention.
Min-Jun Baek +6 more
semanticscholar +1 more source
Molecules, 2023 Rutin is a natural flavonoid that carries out a variety of biological activities, but its application in medicine and food is limited by its water solubility.
Chao-Wan Chang +5 more
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Cyclodextrin-Based Nanosponges: Overview and Opportunities
Frontiers in Chemistry, 2022 Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges.
Gianluca Utzeri +3 more
semanticscholar +1 more source
Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review
Environmental Chemistry Letters, 2022 Metal–organic frameworks are porous polymeric materials formed by linking metal ions with organic bridging ligands. Metal–organic frameworks are used as sensors, catalysts for organic transformations, biomass conversion, photovoltaics, electrochemical ...
Yang Xu +10 more
semanticscholar +1 more source
Advanced Functional Materials, 2020 This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host–guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical solubilizer, fabrication of ...
J. Wankar +5 more
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Polymers, 2021 Cyclodextrin polymers and cyclodextrin-based nanosponges have been widely investigated for increasing drug bioavailability. This study examined curcumin’s complexation stability and solubilization with β-cyclodextrin and β-cyclodextrin-based nanosponge ...
Hadeia Mashaqbeh +2 more
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