Results 41 to 50 of about 172,270 (336)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles

Brazilian Journal of Pharmaceutical Sciences, 2019
Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins
Leticia Norma Carpentieri Rodrigues, Anna Carollina Moraes Tavares, Beatriz Tavares Ferreira, Adriana Karla Cardoso Amorim Reis, Luciana Morita Katiki   +4 more
doaj   +1 more source

Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction

Frontiers in Molecular Biosciences, 2021
Cyclodextrins (CDs) are cyclic oligosaccharides capable of forming water-soluble complexes with a variety of otherwise poorly soluble molecules including cholesterol and different drugs. Consistently, CDs are widely used in research and clinical practice
Tamas Kovacs, Tamas Sohajda, Lajos Szente, Peter Nagy, Gyorgy Panyi, Zoltan Varga, Florina Zakany   +6 more
doaj   +1 more source

Spectroscopic Determination of Binding Constants of Modified β-cyclodextrins with Brooker’s Merocyanine [PDF]

, 2013
Host-guest complexation occurs when a guest molecule is held inside a host molecule through weak molecular forces. β-cyclodextrin, a host molecule, has a variety of uses and is often applied in pharmaceuticals.
Hanson, Carly
core   +2 more sources

Phase diagram of a solution undergoing inverse melting

, 2008
The phase diagram of $\alpha$-cyclodextrin/water/4-methylpyridine solutions, a system undergoing inverse melting, has been studied by differential scanning calorimetry, rheological methods, and X-rays diffraction.
Angelini, R., De Panfilis, S., Ruocco, G., Sette, F.   +3 more
core   +1 more source

Complexation between oleanolic and maslinic acids with native and modified cyclodextrins [PDF]

, 2018
Oleanolic (OA) and maslinic (MA) acids are two natural triterpenoids with a wide range of beneficial effects for human health. However, their low solubility and permeability make their application in the food or industry difficult. The complexation of OA
López Miranda, Santiago
core   +2 more sources

Cyclodextrin‐Templated Porphyrin Nanorings [PDF]

Angewandte Chemie International Edition, 2014
Abstractα‐ and β‐Cyclodextrins have been used as scaffolds for the synthesis of six‐ and seven‐legged templates by functionalizing every primary CH2OH with a 4‐pyridyl moiety. Although these templates are flexible, they are very effective for directing the synthesis of macrocyclic porphyrin oligomers consisting of six or seven porphyrin units.
Pengpeng Liu, Patrik Neuhaus, Dmitry V. Kondratuk, T. Silviu Balaban, Harry L. Anderson   +4 more
openaire   +3 more sources

Using the Photostationary State of Arylazopyrazoles to Control Phase Transitions of Liquid Crystals

Advanced Functional Materials, EarlyView.
A series of new arylazopyrazole photoswitches is designed as dopants for liquid crystalline materials. Unprecedented, the distribution of photoisomers at the photostationary state upon irradiation with light of specific wavelengths (365, 460, 520 nm) is used to control the liquid crystalline phase transitions under isothermal conditions, including ...
Tobias Thiele, Kristina Hrybenko, Christoph Wölper, Michael Giese   +3 more
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Repetitive stability study of remdesivir/cyclodextrin complex on the international space station

Scientific Reports
Stability assessment of drugs in space is particularly important for future missions. In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and ...
György Dormán, Balázs Buchholcz, István Puskás, Pál Szabó, Erzsébet Varga, Lajos Szente, György M. Keserű, Ferenc Darvas   +7 more
doaj   +1 more source