Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]
Journal of Medicinal Chemistry, 2007 he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P +17 more
core +9 more sources
Significance of cyclooxygenase-2 in oncogenesis [PDF]
Journal of Veterinary Research, 2019 The cyclooxygenase-2 (COX-2) enzyme catalyses the first stage of biosynthesis of prostanoids, proteins that are implicated in various physiological and pathological processes in humans and animals.
Szweda Marta +3 more
doaj +4 more sources
Cyclooxygenase-2/prostaglandin E2 pathway orchestrates the replication of infectious bronchitis virus in chicken tracheal explants [PDF]
Microbiology SpectrumIn this study, we investigated the localized pathogenesis of infectious bronchitis virus (IBV) in chicken tracheal organ cultures (TOCs), focusing on the role of inducible cyclooxygenase (COX-2).
Motamed Elsayed Mahmoud +7 more
doaj +2 more sources
Preoperative oral treatment with cyclooxygenase‐2 inhibitor for cystitis glandularis [PDF]
IJU Case ReportsIntroduction A previous report has shown that cyclooxygenase‐2 inhibitors can prevent the recurrence of cystitis glandularis postoperatively. Herein, we present a case of cystitis glandularis in which the tumor volume was markedly reduced by preoperative
Masato Yanagi +6 more
doaj +2 more sources
Cyclooxygenase-2 (COX-2) Expression in Equine Melanocytic Tumors [PDF]
Veterinary SciencesEquine melanocytic tumors are common and have an unusual benign behavior with low invasiveness and metastatic rates. However, tumoral mass growth is usually a concern that can have life-threatening consequences. COX-2 is related to oncogenesis, promoting
José Pimenta +3 more
doaj +2 more sources
Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
doaj +1 more source
Prostaglandin Synthase 2/Cyclooxygenase 2 Gene Polymorphisms and Susceptibility to Urothelial Bladder Cancer in an Iranian Population [PDF]
Middle East Journal of Cancer, 2022 Background: Prostaglandin-endoperoxide synthase 2, recognized as cyclooxygenase 2 (COX-2), is an important enzyme contributing to the generation of proinflammatory prostaglandins.
Kamyar Mansori +3 more
doaj +1 more source
Endometritis in the bitch: Immunohistochemical localization of cyclooxygenase 2 [PDF]
Open Veterinary Journal, 2020 Background: In several mammals, subfertility or infertility associated with endometritis was reported. Although there have been studies about endometritis in bitches, the pathophysiological mechanisms it is not completely known. Aim: This study aimed to
María Carla García Mitacek +4 more
doaj +1 more source
Cyclooxygenase-2 in Endometriosis [PDF]
International Journal of Biological Sciences, 2019 Endometriosis (EMS) is the most common gynecological disease in women of reproductive age, and it is associated with chronic pelvic pain, dyspareunia and infertility. As a consequence of genetic, immune and environmental factors, endometriotic lesions have high cyclooxygenase (COX)-2 and COX-2-derived prostaglandin E2 (PGE2) biosynthesis compared with ...
Rui Zhu +10 more
openaire +2 more sources
Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development
Frontiers in Immunology, 2021 Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead to the promotion of breast cancer.
Christoph F. A. Vogel +16 more
doaj +1 more source