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Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs [PDF]

Membranes
The primary mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is inhibition of prostaglandin production mediated by cyclooxygenase. Given the possible association of cyclooxygenase-2, but not cyclooxygenase-1, with membrane lipid rafts, we ...
Maki Mizogami, Hiroki Iida, Hironori Tsuchiya   +2 more
doaj   +2 more sources

Preoperative oral treatment with cyclooxygenase‐2 inhibitor for cystitis glandularis [PDF]

IJU Case Reports
Introduction A previous report has shown that cyclooxygenase‐2 inhibitors can prevent the recurrence of cystitis glandularis postoperatively. Herein, we present a case of cystitis glandularis in which the tumor volume was markedly reduced by preoperative
Masato Yanagi, Norio Motoda, Akifumi Katsu, Hiroyoshi Kono, Ryoji Kimata, Tsutomu Hamasaki, Yukihiro Kondo   +6 more
doaj   +2 more sources

Prostaglandin Synthase 2/Cyclooxygenase 2 Gene Polymorphisms and Susceptibility to Urothelial Bladder Cancer in an Iranian Population [PDF]

Middle East Journal of Cancer, 2022
Background: Prostaglandin-endoperoxide synthase 2, recognized as cyclooxygenase 2 (COX-2), is an important enzyme contributing to the generation of proinflammatory prostaglandins.
Kamyar Mansori, Mohammad Reza Nowroozi, Amirreza Farzin, Solmaz Ohadian Moghadam   +3 more
doaj   +1 more source

Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]

Annals of Coloproctology, 2022
Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
doaj   +1 more source

Endometritis in the bitch: Immunohistochemical localization of cyclooxygenase 2 [PDF]

Open Veterinary Journal, 2020
Background: In several mammals, subfertility or infertility associated with endometritis was reported. Although there have been studies about endometritis in bitches, the pathophysiological mechanisms it is not completely known. Aim: This study aimed to
María Carla García Mitacek, Romina Gisele Praderio, María Cecilia Stornelli, Rodolfo Luzbel de la Sota, María Alejandra Stornelli   +4 more
doaj   +1 more source

Cyclooxygenase-2 [PDF]

OncoImmunology, 2013
Cyclooxygenase-2 and its product PGE2 play essential roles in inducing and maintaining the suppressive functions of MDSCs in cancer. Blockade of the COX-2/PGE2 pathway abolishes the induction of MDSCs in response to tumor-derived factors and thus may provide new opportunities for targeting MDSCs in cancer patients.
Yumeng Mao, Isabel Poschke, Rolf Kiessling   +2 more
openaire   +2 more sources

Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development

Frontiers in Immunology, 2021
Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead to the promotion of breast cancer.
Christoph F. A. Vogel, Christoph F. A. Vogel, Gwendal Lazennec, Sarah Y. Kado, Carla Dahlem, Yi He, Alejandro Castaneda, Yasuhiro Ishihara, Yasuhiro Ishihara, Christian Vogeley, Andrea Rossi, Thomas Haarmann-Stemmann, Juliann Jugan, Hidetoshi Mori, Alexander D. Borowsky, Michele A. La Merrill, Colleen Sweeney   +16 more
doaj   +1 more source

Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features [PDF]

Türk Patoloji Dergisi, 2017
Objective: Colorectal carcinoma is the most common neoplasm of the gastrointestinal tract. COX-2 expression is upregulated in colorectal carcinoma. Therefore its assessment would identify patients amenable to adjuvant anticyclooxygenase therapy.
Sandhya VENKATACHALA, Manjula RAJENDRAN
doaj   +1 more source

Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for Enhanced Anti-Inflammatory Action

Pharmaceuticals, 2023
Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology.
Samar Zuhair Alshawwa, Thanaa A. El-Masry, Engy Elekhnawy, Hadil Faris Alotaibi, Al-Sayed Sallam, Dalia H. Abdelkader   +5 more
doaj   +1 more source

Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas

BMC Endocrine Disorders, 2020
Background Pituitary adenomas as multifactorial intracranial neoplasms impose a massive burden of morbidity on patients and characterizing the molecular mechanism underlying their pathogenesis has received considerable attention.
Nasrin Akbari, Mohammad Ghorbani, Vahid Salimi, Alimohammad Alimohammadi, Mohammad E. Khamseh, Hamideh Akbari, Mitra Nourbakhsh, Alireza Sheikhi, S. Fahimeh Taghavi, Masoumeh Tavakoli-Yaraki   +9 more
doaj   +1 more source