Results 21 to 30 of about 22,053,927 (171)

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.

New England Journal of Medicine, 2000
BACKGROUND Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2 ...
G. Steinbach, P. Lynch, R. Phillips, M. Wallace, E. Hawk, G. Gordon, Naoki Wakabayashi, B. Saunders, Yu Shen, T. Fujimura, L. Su, B. Levin, L. Godio, S. Patterson, M. Rodriguez-Bigas, Susan L. Jester, K. King, M. Schumacher, J. Abbruzzese, R. Dubois, W. Hittelman, Stuart Zimmerman, J. Sherman, G. Kelloff   +23 more
semanticscholar   +1 more source

Changing prostaglandin E2 (PGE2) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE2 receptor EP2 and EP4

Reproductive Medicine and Biology, 2022
Purpose We investigated the change, if any, in prostaglandin E2 (PGE2) signaling in endometriotic lesions of different developmental stages in mouse.
Qingqing Huang, Xishi Liu, Sun‐Wei Guo
doaj   +1 more source

Research progress on COX-2/PGE₂/EP₄ signaling axis in colon cancer

Zhongguo linchuang yanjiu, 2023
The expression of cyclooxygenase 2 (COX-2) was up-regulated and prostaglandin E2 (PGE2) was significantly increased in colon cancer patients. As the main prostaglandin produced by COX-2, PGE2 plays an important role in angiogenesis, survival, invasion ...
ZHENG Lirong, DU Haoyang, ZHANG Ruifen, ZHANG Hairong, BAO Aruhan, YU Lei, CUI Hongwei   +6 more
doaj   +1 more source

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

Frontiers in Psychiatry, 2019
Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi, N. Gómez-Coronado, A. Walker, O. Robertson, Bruno Agustini, M. Berk, S. Dodd   +6 more
semanticscholar   +1 more source

Antiinflamatórios não-hormonais: inibidores da ciclooxigenase 2 Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors

Jornal de Pediatria, 2006
OBJETIVO: Analisar os antiinflamatórios não-hormonais (AINH) inibidores seletivos da Cox 2 quanto ao mecanismo de ação, principais indicações, posologia e efeitos adversos mais comuns.
Maria Odete Esteves Hilário, Maria Teresa Terreri, Cláudio Arnaldo Len   +2 more
doaj   +1 more source

Cyclooxygenase-2 in Endometriosis

International Journal on Biological Sciences, 2019
Endometriosis (EMS) is the most common gynecological disease in women of reproductive age, and it is associated with chronic pelvic pain, dyspareunia and infertility.
Zhen-zhen Lai, Hui-Li Yang, Si-Yao Ha, Kaikai Chang, J. Mei, We-Jie Zhou, Xue-min Qiu, Xiao-Qiu Wang, Rui Zhu, Dajin Li, Ming-qing Li   +10 more
semanticscholar   +1 more source

Cyclooxygenase-2 in Cardiovascular Biology

Clinical Medicine Insights: Cardiology, 2008
Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2.
Joseph F. Murphy
doaj   +1 more source

Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress

Emerging Microbes and Infections, 2022
The role of gut microbiota has been described as an important influencer of the immune system. Gut-lung axis is critical in the prevention of mycobacterium infection, but the specific mechanism, by which dysbiosis affects tuberculosis, has not been ...
Haoran Wang, Jiao Yao, Yulan Chen, Yuanzhi Wang, Yiduo Liu, Yi Liao, Zhengmin Liang, Yu hui Dong, Mengjin Qu, Xin Ge, Xiangmei Zhou   +10 more
doaj   +1 more source

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases.

Current Medicinal Chemistry, 2018
Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, and cardiovascular pathologies.
M. Ferrer, Carla Busquests-Cortes, X. Capó, S. Tejada, J. Tur, A. Pons, A. Sureda   +6 more
semanticscholar   +1 more source

Cyclooxygenase‐2 in gastrointestinal malignancies

Cancer, 2019
Cyclooxygenase (COX) is an enzyme complex that plays an important role in the conversion of arachidonic acid to prostaglandins. Prostaglandins are essential modulators of signal transduction pathways, which contribute to the metastatic properties of ...
G. Nagaraju, B. El-Rayes
semanticscholar   +1 more source