Results 181 to 190 of about 50,064 (212)
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Role of cyclophilin a during oncogenesis
Archives of Pharmacal Research, 2010Cyclophilins (Cyps) are ubiquitously expressed proteins that are evolutionarily conserved. CypA is the most abundant among the Cyps and is expressed in the cytosol. With its chaperone and PPIase activities, CypA contributes to the maintenance of correct conformation of nascent or denatured proteins and also provides protection against environmental ...
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Cyclophilin A facilitates HIV-1 integration
Journal of VirologyABSTRACT Cyclophilin A (CypA) binds to the HIV-1 capsid to facilitate reverse transcription and nuclear entry and counter the antiviral activity of TRIM5α. Interestingly, recent studies suggest that the capsid enters the nucleus of an infected cell and uncoats prior to integration.
Adrian Padron +11 more
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Cyclophilins in Atherosclerosis: A New Therapeutic Target?
Current Pharmaceutical Design, 2013Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible ...
Michael, Bukrinsky +3 more
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Engineering cyclophilin into a proline-specific endopeptidase
Nature, 1998Designing an enzyme requires, among a number of parameters, the appropriate positioning of catalytic machinery within a substrate-binding cleft. Using the structures of cyclophilin-peptide complexes, we have engineered a new catalytic activity into an Escherichia coli cyclophilin by mutating three amino acids, close to the peptide binding cleft, to ...
Quéméneur, Eric +3 more
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Cyclophilin A as a Target of Cisplatin Chemosensitizers
Current Cancer Drug Targets, 2014Platinum-based chemotherapeutics are the mainstay of treatment of a range of tumors achieving high response rates but limited in the course of disease by appearance of drug resistance. Tumor cells respond with reduced uptake and increased intracellular inactivation of the drugs, as well as increased DNA repair and general resistance to ...
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Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A
Science, 1984Cyclophilin, a specific cytosolic binding protein responsible for the concentration of the immunosuppressant cyclosporin A by lymphoid cells, was purified to homogeneity from bovine thymocytes. Cation-exchange high-performance liquid chromatography resolved a major and minor cyclophilin species that bind cyclosporin A with a dissociation ...
R E, Handschumacher +4 more
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Cyclophilin A Facilitates HIV-1 DNA Integration
AbstractCyclophilin A (CypA) promotes HIV-1 infection by facilitating reverse transcription, nuclear entry and by countering the antiviral activity of TRIM5α. These multifunctional roles of CypA are driven by its binding to the viral capsid. Interestingly, recent studies suggest that the HIV-1 capsid lattice enters the nucleus of an infected cell and ...Adrian Padron +11 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Cyclophilin A and HIV-1 Replication
2013The gag gene of HIV-1 and other retroviruses encodes a polyprotein that is sufficient to direct the assembly of virions (Life Cycle Overview; Virus Assembly; Franke et al. 1994). The Gag polyprotein is targeted to the plasma membrane where it buds out of the cell. Concurrent with virion budding, the viral protease is activated.
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