Results 101 to 110 of about 30,484 (184)

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid-Based Electrochemical Sensors. [PDF]

Angew Chem Int Ed Engl, 2022
Clark V, Waters K, Orsburn B, Bumpus NN, Kundu N, Sczepanski JT, Ray P, Arroyo-Currás N.   +7 more
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual‐Purpose Defense Metabolite in Sorghum bicolor

Plant Direct, Volume 10, Issue 8, August 2026.
ABSTRACT Dhurrin, a cyanogenic glucoside, plays an important role in Sorghum bicolor physiology and defense. The concentration of dhurrin in sorghum is influenced by both nitrogen status and stage of plant organ development. While nitrogen resupply activates the expression of genes for dhurrin biosynthesis, the molecular mechanisms underlying this ...
Alicia A. Quinn, Brian A. McKinley, Cecilia K. Blomstedt, John E. Mullet, Roslyn M. Gleadow   +4 more
wiley   +1 more source

Extracellular cyclophilin A promotes B-cell acute lymphoblastic leukemia progression via MC2R

EMBO Molecular Medicine
B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy characterized by rapid proliferation of immature lymphoid cells. Despite treatment advancements, relapse remains a significant challenge.
Han Zhong Pei, Heqiao Li, Hongman Xue, Wenqing Wang, He Zhang, Zeqiu Fan, Xiaoyuan Bai, Fei Han, Qingmei Li, Yuna Zhao, Lu Yu, Xiaoxiao Jia, Yao Guo, Wenjun Liu, Lei Sun   +14 more
doaj   +1 more source

Rapid and efficient quality control analysis of isolated mitochondria by interferometric light microscopy

VIEW, Volume 7, Issue 4, August 2026.
Mitochrial transplantation is a promising therapy to restore energy in damaged cells, but it lacks fast and reliable methods to assess mitochondrial quality before use. In this study, we used a label‐free imaging technique called interferometric light microscopy to rapidly measure the size and concentration of isolated mitochondria.
Sabah Mozafari, Christopher Ribes, Dmitry Ayollo, Florence Gazeau, Amanda K. A. Silva, Kelly Aubertin   +5 more
wiley   +1 more source

Machine learning‐driven investigation on liquid–liquid phase separation‐related prognostic signature in diffuse large B‐cell lymphoma

British Journal of Haematology, Volume 209, Issue 2, Page 461-468, August 2026.
Summary Diffuse large B‐cell lymphoma (DLBCL) is the most common aggressive non‐Hodgkin lymphoma and is characterized by substantial heterogeneity. This study aimed to develop a liquid–liquid phase separation (LLPS)‐related prognostic model to improve risk stratification.
Zhen‐Zhong Zhou, Jia‐Chen Lu, Zhao Wang, Rong‐Hui Chen, Hai‐Long Li, Wan‐Ting Chen, Yu‐Ning Deng, Hui‐Juan Zhang, Yu Wang, Xuan‐Ye Zhang, Wei‐Juan Huang, Xiao‐Peng Tian   +11 more
wiley   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Time-Resolved Metabolomics Reveals Mitochondrial Protection in Septic Liver Injury

Metabolites
Background/Objectives: Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated host response to infection. Mitochondrial dysfunction is considered a key contributor to the pathogenesis of sepsis, but its molecular ...
Naoki Suzuki, Shoichiro Shibata, Masahiro Sugimoto, Eskil Elmer, Hiroyuki Uchino   +4 more
doaj   +1 more source