RAS Inhibitor RMC‐7977 Blocks Vascular Overgrowth of NRASQ61R Mutant Endothelial Cells
Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.ABSTRACT RAS mutations occur in patients with several types of vascular anomalies, but effective treatments remain limited. To address this need, we evaluated the RAS (ON) multi‐selective inhibitor RMC‐7977 in human endothelial cells (ECs) expressing the NRASQ61R mutation found in kaposiform lymphangiomatosis (KLA).
Sara Alharbi +6 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.ABSTRACT Porphyromonas gingivalis (P. gingivalis), a keystone pathogen in periodontitis, has been increasingly recognised as a mechanistic bridge linking periodontal infection to pathological destruction in distant organs. P. gingivalis virulence factors, including gingipains, lipopolysaccharides (LPS), and outer membrane vesicles (OMVs), mediate ...
Alaa Ahmed Basalim +1 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 8, Page 5078-5094, August 2026.ABSTRACT Mycorrhizal symbiosis shapes plant growth and stress resilience. Here, we compared physiological and molecular responses of poplars (P. x canescens) colonised by Paxillus involutus (Pi) or Cenococcum geophilum (Cg) under control conditions, drought stress and recovery.
Huili Shi, Zhuchou Lu, Andrea Polle
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Veterinary Dermatology, Volume 37, Issue 4, Page 478-487, August 2026.Background: Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined.
Treasa Clifford +5 more
wiley +1 more source
Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury
The Journal of Physiology, Volume 604, Issue 16, Page 6659-6674, 15 August 2026.Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich +5 more
wiley +1 more source
Cyclophilin B overexpression predicts a poor prognosis and activates metastatic pathways in colon cancer. [PDF]
Transl Cancer Res, 2020 Zhang X, Tan J, Yang L, An G.
europepmc +1 more source
Inorganic polyphosphate controls cyclophilin B-mediated collagen folding in osteoblast-like cells. [PDF]
FEBS J, 2020 Khong ML +4 more
europepmc +1 more source
Biophysical characterization of Cyclophilin B reveals membrane localization as its primary functional determinant as a prolyl isomerase. [PDF]
Protein SciDeVoe SC +7 more
europepmc +1 more source
Optimization of Cyclophilin B-Targeted Tri-vector Inhibitors for Novel MASH Treatments. [PDF]
J Med ChemKouridaki ME +16 more
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Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1). [PDF]
Int J Mol Sci, 2019 Gómez-Fernández P +5 more
europepmc +1 more source