Identification and characterization of a nonpeptidic cyclophilin ligand with antiviral activity against feline and porcine α-coronaviruses [PDF]
Veterinary ResearchCoronaviruses (CoVs) are emerging pathogens that have been extensively studied over the last twenty years and can cause acute respiratory diseases in humans, as exemplified by the SARS-CoV-2 pandemic.
Manon Delaplace +9 more
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Biochemical and functional characterization of Brucella abortus cyclophilins: So similar, yet so different [PDF]
Frontiers in Microbiology, 2022 Brucella spp. are the etiological agent of animal and human brucellosis. We have reported previously that cyclophilins of Brucella (CypA and CypB) are upregulated within the intraphagosomal replicative niche and required for stress adaptation and host ...
Emanuel J. Muruaga +5 more
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Cyclophilins as key players in protozoan parasite infections [PDF]
Parasites & VectorsCyclophilins (Cyps), a highly conserved family of immunophilins with peptidyl-prolyl cis-trans isomerase (PPIase) activity, play pivotal roles in protein folding, cell signaling, immune modulation, and host–pathogen interactions. In protozoan infections,
Reza Mansouri +7 more
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Macrophages signal cross-talks under hyperglycemic conditions and their link to cyclophilins [PDF]
Molecular MedicineBackground Hyperglycemia is associated with pro-inflammatory reprogramming of macrophages, increase of reactive oxygen species (ROS) levels and variations in ATP consumption.
Noelia Castedo +4 more
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Cyclophilin Inhibitor Rencofilstat Combined with Proteasome Inhibitor Ixazomib Increases Proteotoxic Cell Death in Advanced Prostate Cancer Cells with Minimal Effects on Non-Cancer Cells [PDF]
BiomedicinesBackground/Objective: Proteotoxic stress induced by inhibitors of the ubiquitin–proteasome system has been successful in multiple myeloma but not in solid cancers such as prostate cancer.
Carlos Perez-Stable +4 more
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HIV, cyclophilins and nuclear entry: going under the radar [PDF]
Retrovirology, 2011 Towers Greg
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Pathogens, 2021 Cyclophilins are cellular peptidyl-prolyl isomerases that play an important role in viral infections, with demonstrated roles in the replication of hepatitis C virus (HCV) and other viruses in the Flaviviridae family, such as dengue virus (DENV) and ...
Carla E. Gallardo-Flores +1 more
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Association of cyclophilins and cardiovascular risk factors in coronary artery disease
Frontiers in Physiology, 2023 Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary artery
Sandra Gegunde +22 more
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Cyclophilins and Their Functions in Abiotic Stress and Plant–Microbe Interactions
Biomolecules, 2021 Plants have developed a variety of mechanisms and regulatory pathways to change their gene expression profiles in response to abiotic stress conditions and plant–microbe interactions. The plant–microbe interaction can be pathogenic or beneficial.
Przemysław Olejnik +2 more
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PLoS ONE, 2022 Cyclophilins, a type of peptidyl-prolyl cis-trans isomerase, function as important molecular chaperones in a series of biological processes. However, the expression pattern and signal transduction pathway of cyclophilins are still unclear.
Hongbo Liu +5 more
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