Results 1 to 10 of about 21,746 (290)

Thiazolylcyanocyclopropanes: Novel Donor–Acceptor Cyclopropanes for Accessing Thiazole-Containing Targets [PDF]

Molecules
Donor–acceptor (D–A) cyclopropanes are important precursors in the synthesis of complex molecules due to their bidentate character and high reactivity.
Emanuèl Bruno Savini, Edoardo Bandieri, Pietro Pecchini, Nicolò Santarelli, Luca Bernardi, Mariafrancesca Fochi   +5 more
doaj   +2 more sources

Enantioselective intramolecular cyclopropanation via a cationic sulfoxonium-Rh-carbene [PDF]

Nature Communications
The synthesis of heavily substituted chiral cyclopropanes presents a significant challenge in organic chemistry due to the inherent strain and steric congestion of these three-membered rings.
Yajie Xing, Yuqi Fang, Farshad Shiri, Zhenyang Lin, Jiean Chen, Zhaofeng Wang, Yong Huang   +6 more
doaj   +2 more sources

Synthesis of Stable Betaines Based on 1H-Pyrrole-2,3-diones and Pyridinium Ylides and Their Thermal Conversion to Cyclopropane-Fused Pyrroles [PDF]

Molecules
Pyridinium ylides, along with related azaheterocyclic ylides, are widely used in synthetic organic chemistry. However, reactions that yield stable zwitterionic adducts from these ylides remain underexplored. In this work, we demonstrate that the reaction
Maria M. Muranova, Andrey R. Galeev, Ivan G. Mokrushin, Andrey N. Maslivets, Maksim V. Dmitriev   +4 more
doaj   +2 more sources

A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening [PDF]

Nature Communications, 2017
Functionalizing multiple, distant sites across a molecule is a challenge. Here the authors report a remote functionalization strategy, whereby an initial Heck reaction leads to chain-walking of palladium across a molecule, ring-opening cyclopropanes ...
Sukhdev Singh, Jeffrey Bruffaerts, Alexandre Vasseur, Ilan Marek   +3 more
doaj   +2 more sources

Organocatalytic activation of cyclopropanes in asymmetric synthesis

Tetrahedron Chem, 2023
Cyclopropanes are strained carbocycles that can undergo ring opening reactions in which one of the C–C bond present in the cycle is broken following a radical or ionic mechanism.
Efraím Reyes, Uxue Uria, Liher Prieto, Luisa Carrillo, Jose L. Vicario   +4 more
doaj   +1 more source

Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones

Molecules, 2020
A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed.
Alexander A. Fadeev, Alexey O. Chagarovskiy, Anton S. Makarov, Irina I. Levina, Olga A. Ivanova, Maxim G. Uchuskin, Igor V. Trushkov   +6 more
doaj   +1 more source

Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines

Molecules, 2022
We developed a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor–acceptor cyclopropanes bearing an ester group as one of the acceptor substituents.
Maksim A. Boichenko, Andrey Yu. Plodukhin, Vitaly V. Shorokhov, Danyla S. Lebedev, Anastasya V. Filippova, Sergey S. Zhokhov, Elena A. Tarasenko, Victor B. Rybakov, Igor V. Trushkov, Olga A. Ivanova   +9 more
doaj   +1 more source

Continuous-Flow Synthesis of Arylthio-Cyclopropyl Carbonyl Compounds

Molecules, 2022
The straightforward, continuous-flow synthesis of cyclopropyl carbaldehydes and ketones has been developed starting from 2-hydroxycyclobutanones and aryl thiols.
Davide Moi, Maria Chiara Cabua, Viktoria Velichko, Andrea Cocco, Annalisa Chiappone, Rita Mocci, Stefania Porcu, Monica Piras, Stefano Bianco, Fabio Pesciaioli, Francesco Secci   +10 more
doaj   +1 more source

Trifunktionelle Cyclopropane als Vorstufen von Triafulven und Calicen

CHIMIA, 1981
A series of 1,1-dihalo-2-X-cyclopropanes 3 have been prepared and characterised. Cyclopropanes of type 3 could be of interest as starting materials with respect to the attempted synthesis of triafulvene and calicene.
Andreas Weber, Gabriele Sabbioni, Roberto Galli, Markus Neuenschwander   +3 more
doaj   +1 more source

Synthesis of cyclopropyl-substituted furans by Brønsted acid promoted cascade reactions [PDF]

, 2015
Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of electron-deficient ynenones to deliver products featuring a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substituent at the 5-position ...
Achmatowicz, Albrecht, Barluenga, Benary, Boto, Casey, Ciufolini, Clark, Corma, Csuk, Csuk, Donaldson, Donohoe, Fedoryński, Feist, Fritz, Gandini, Gilchrist, González, González, Hashmi, Hou, Högberg, Jung, Knorr, Kobayashi, Krasnaya, Kuroda, Lebel, Li, Li, Lipshutz, Ma, MacMillan, Paal, Pellissier, Ripaud, Sperry, Vicente, Wang, Wessjohann, Wipf, Wu, Xia, Yang, Zhang, Zimmerman   +46 more
core   +2 more sources