Results 1 to 10 of about 5,651 (185)

Thiazolylcyanocyclopropanes: Novel Donor–Acceptor Cyclopropanes for Accessing Thiazole-Containing Targets [PDF]

Molecules
Donor–acceptor (D–A) cyclopropanes are important precursors in the synthesis of complex molecules due to their bidentate character and high reactivity.
Emanuèl Bruno Savini, Edoardo Bandieri, Pietro Pecchini, Nicolò Santarelli, Luca Bernardi, Mariafrancesca Fochi   +5 more
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Highly electrophilic, gem- and spiro-activated trichloromethylnitrocyclopropanes: synthesis and structure [PDF]

Beilstein Journal of Organic Chemistry
New highly electrophilic gem- and spiro-activated trichloromethylnitrocyclopropanes were obtained by the Michael-initiated ring closure (MIRC) reaction of 1-bromo-1-nitro-3,3,3-trichloropropene with linear and cyclic CH-acids catalyzed by bases ...
Ilia A. Pilipenko, Mikhail V. Grigoriev, Olga Yu. Ozerova, Igor A. Litvinov, Darya V. Spiridonova, Aleksander V. Vasilyev, Sergey V. Makarenko   +6 more
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Enantioselective intramolecular cyclopropanation via a cationic sulfoxonium-Rh-carbene [PDF]

Nature Communications
The synthesis of heavily substituted chiral cyclopropanes presents a significant challenge in organic chemistry due to the inherent strain and steric congestion of these three-membered rings.
Yajie Xing, Yuqi Fang, Farshad Shiri, Zhenyang Lin, Jiean Chen, Zhaofeng Wang, Yong Huang   +6 more
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Synthesis of Stable Betaines Based on 1H-Pyrrole-2,3-diones and Pyridinium Ylides and Their Thermal Conversion to Cyclopropane-Fused Pyrroles [PDF]

Molecules
Pyridinium ylides, along with related azaheterocyclic ylides, are widely used in synthetic organic chemistry. However, reactions that yield stable zwitterionic adducts from these ylides remain underexplored. In this work, we demonstrate that the reaction
Maria M. Muranova, Andrey R. Galeev, Ivan G. Mokrushin, Andrey N. Maslivets, Maksim V. Dmitriev   +4 more
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Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones

Molecules, 2020
A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed.
Alexander A. Fadeev, Alexey O. Chagarovskiy, Anton S. Makarov, Irina I. Levina, Olga A. Ivanova, Maxim G. Uchuskin, Igor V. Trushkov   +6 more
doaj   +1 more source

Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines

Molecules, 2022
We developed a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor–acceptor cyclopropanes bearing an ester group as one of the acceptor substituents.
Maksim A. Boichenko, Andrey Yu. Plodukhin, Vitaly V. Shorokhov, Danyla S. Lebedev, Anastasya V. Filippova, Sergey S. Zhokhov, Elena A. Tarasenko, Victor B. Rybakov, Igor V. Trushkov, Olga A. Ivanova   +9 more
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Organocatalytic activation of cyclopropanes in asymmetric synthesis

Tetrahedron Chem, 2023
Cyclopropanes are strained carbocycles that can undergo ring opening reactions in which one of the C–C bond present in the cycle is broken following a radical or ionic mechanism.
Efraím Reyes, Uxue Uria, Liher Prieto, Luisa Carrillo, Jose L. Vicario   +4 more
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Continuous-Flow Synthesis of Arylthio-Cyclopropyl Carbonyl Compounds

Molecules, 2022
The straightforward, continuous-flow synthesis of cyclopropyl carbaldehydes and ketones has been developed starting from 2-hydroxycyclobutanones and aryl thiols.
Davide Moi, Maria Chiara Cabua, Viktoria Velichko, Andrea Cocco, Annalisa Chiappone, Rita Mocci, Stefania Porcu, Monica Piras, Stefano Bianco, Fabio Pesciaioli, Francesco Secci   +10 more
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Trifunktionelle Cyclopropane als Vorstufen von Triafulven und Calicen

CHIMIA, 1981
A series of 1,1-dihalo-2-X-cyclopropanes 3 have been prepared and characterised. Cyclopropanes of type 3 could be of interest as starting materials with respect to the attempted synthesis of triafulvene and calicene.
Andreas Weber, Gabriele Sabbioni, Roberto Galli, Markus Neuenschwander   +3 more
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The Solubility Studies and the Complexation Mechanism Investigations of Biologically Active Spiro[cyclopropane-1,3′-oxindoles] with β-Cyclodextrins

Pharmaceutics, 2023
In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3′-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation.
Anna A. Kravtsova, Anna A. Skuredina, Alexander S. Malyshev, Irina M. Le-Deygen, Elena V. Kudryashova, Ekaterina M. Budynina   +5 more
doaj   +1 more source