Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology
Cells, 2021 Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade.
Ryan D. Readnower +4 more
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Hypereosinophilic Syndrome: A Case of Diagnostic and Therapeutic Difficulty
Sri Lanka Journal of Medicine, 2022 Hypereosinophilic syndrome (HES) is a condition with a diverse clinical presentation and prognosis. Due to its rarity, it is often under-recognized. We present a 48-year-old female patient who presented with eosinophilic pneumonia and bullous pemphigoid;
B. D. Alahakoon +4 more
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Clinics in Dermatology, 1989 Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K. +7 more
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Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]
, 2005 In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Spöhrer, Ute, Vogeser, Michael
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Journal of Transplantation, 2012 The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing.
Dustin Tedesco, Lukas Haragsim
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Immunosuppressive therapy as a risk factor for new-onset diabetes after transplantation
Терапевтический архив, 2020 Aim.To analyze the modes of immunosuppressive therapy as a risk factor for new-onset diabetes after transplantation (NODAT) in kidney recipients. Materials and methods.The retrospective analysis included data from 1367 recipients (755 men and 612 ...
S. S. Allazova +3 more
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The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster. [PDF]
PLoS Genetics, 2013 The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant drug cyclosporin. The draft genome of T.
Kathryn E Bushley +12 more
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Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Since arthritis induced by Mycobacterium products (adjuvant) in rats is considered to be immunologically driven, the objective of the present study was to determine if the immunosuppressor drug cyclosporin could affect hindpaw edema and joint ...
J.N. Francischi +2 more
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Immunosupressive therapy of aplastic anemia patients: successes and failures (single center experiment 2007–2016) [PDF]
Терапевтический архив, 2020 Treatment programs for patients with acquired aplastic anemia include two main therapeutic options: allogeneic bone marrow transplantation and combined immunosuppressive therapy (IST).
E. A. Mikhaylova +13 more
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CYCLOSPORIN A (SANDIMMUN NEORAL) IN THERAPY FOR PSORIASIS AND PSORIATIC ARTHRITIS
Современная ревматология, 2010 The involvement of immune mechanisms in the pathogenesis of psoriatic arthritis (PA) is noted to give grounds to use immunoactive compounds (disease- modifying agents - basic anti-inflammatory drugs -BAIDs), such as cyclosporin A (CsA), in this disease ...
Yulia Leonodovna Korsakova
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