Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]
, 2005 In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Spöhrer, Ute, Vogeser, Michael
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Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. [PDF]
, 2006 Immunophilin is the collective name given to the cyclophilin and FK506-binding protein (FKBP) families. As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A ...
Adams +101 more
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Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation [PDF]
, 2009 CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by ...
Abramov +49 more
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Alterações microvasculares retinianas de aparecimento tardio e persistente após transplante de medula: seguimento de 3 anos [PDF]
, 2002 Purpose: To describe a case of persistent retinopathy after bone marrow transplantation in the absence of radiation therapy. Methods: Case Report.
Belfort, Rubens Junior +4 more
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Clonality, recombination, and hybridization in the plumbing-inhabiting human pathogen Fusarium keratoplasticum inferred from multilocus sequence typing [PDF]
, 2013 Sammanfattning/AbstractHelene Erös och Jennie Karlsson (2013). Action programs as tool for learning.Specialpedagogprogrammet 90hp Skolutveckling och ledarskap Lärande och samhälle, Malmö högskolaProblemområde: Skolverket (2012) presenterade nyligen de ...
Dylan PG Short +2 more
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Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells [PDF]
, 2013 The protein known as eIF5A (eukaryotic initiation factor 5A) has an elusive role in translation. It has a unique and essential hypusine modification at a conserved lysine residue in most eukaryotes.
Castilho, Beatriz A. +4 more
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, 2010 Fungal immunomodulators are high-value compounds in nutraceuticals and the high-value pharmaceutical market. Fungal immunosuppressors such as cyclosporins, mycophenolic acid and their derivatives are important medicines for the treatment of many diseases;
El Enshasy, Hesham
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Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed α-helix [PDF]
, 2014 The macrophage infectivity potentiator protein from Trypanosoma cruzi (TcMIP) is a major virulence factor secreted by the etiological agent of Chagas' disease. It is functionally involved in host cell invasion.
Coll, Miquel +8 more
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Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism [PDF]
, 2013 Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the ...
A Kuroishi +75 more
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Pulmonary phaeohyphomycosis caused by phaeoacremonium in a kidney transplant recipient: Successful treatment with posaconazole [PDF]
, 2014 We report a rare case of pulmonary phaeohyphomycosis in a 49-year-old woman 6 years after kidney transplantation. She presented with dyspnea, cough, and fatigue. Her chest CT scan revealed nodular opacities in the right upper lung. A fine needle aspirate
Brennan, Daniel C +4 more
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