Results 161 to 170 of about 13,126 (201)

Organization of the Human Aromatase P450 (CYP19) Gene

Seminars in Reproductive Medicine, 2004
The human CYP19 (p450arom) gene is located in the 21.2 region on the long arm of chromosome 15 (15q21.2). This gene spans a region that consists of a 30 kb coding region and a 93 kb regulatory region ( approximately 123 kb total length). Its regulatory region contains at least 10 distinct promoters regulated in a tissue- or signaling pathway-specific ...
Serdar E, Bulun, Kazuto, Takayama, Takashi, Suzuki, Hironobu, Sasano, Bertan, Yilmaz, Siby, Sebastian   +5 more
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Bisphenol A downregulates CYP19 transcription in JEG-3 cells

Toxicology Letters, 2009
Bisphenol A is an industrial contaminant and is considered to be an endocrine disruptor; its estrogenic property has been reported in many studies. Because of its ubiquitous existence in our environment, bisphenol A has drawn much discussion on its safety issues. Estrogen is important in the maintenance of human pregnancy, and the placenta is the major
Hui, Huang, Lai K, Leung
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Inhibition of human aromatase complex (CYP19) by antiepileptic drugs

Toxicology in Vitro, 2008
Antiepileptic drugs and epilepsy are often associated with sexual disorder in women such as hyperandrogenism, menstrual disorders and ovarian cysts. In children, until puberty, a hormone imbalance may influence many aspects of development, e.g. growth and sexual maturation. The aromatase complex is the enzyme system that converts androgens to estrogens
Jacobsen, Naja Wessel, Halling-Sørensen, Bent, Birkved, Franziska Maria A Kramer   +2 more
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A High-Throughput Screen to Identify Inhibitors of Aromatase (CYP19)

Analytical Biochemistry, 2000
Summary of IC 50 Values for the Test Compounds a Test compoundIC 50 value (mM)Day 1 Day 2 Mean Range/meanOrg 30365 0.0026 0.0016 0.0021 0.24Org 30958 0.0198 0.0079 0.0138 0.434-OHA 0.028 0.034 0.031 0.10Androstenedione 0.068 0.096 0.082 0.17Testosterone 0.126 0.240 0.183 0.31ANF 0.149 0.207 0.178 0.16Chrysin 0.60 0.79 0.70 0.13AG 0.61 0.93 0.77 0 ...
D M, Stresser, S D, Turner, J, McNamara, P, Stocker, V P, Miller, C L, Crespi, C J, Patten   +6 more
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CYP19 (aromatase) haplotypes and endometrial cancer risk

International Journal of Cancer, 2005
AbstractEndogenous estrogen exposure is an important determinant of endometrial cancer risk. Aromatase, encoded by CYP19, catalyzes the aromatization of androstenedione and testosterone to estrone and estradiol, respectively. Several common genetic polymorphisms in CYP19 have been identified, including a TCT insertion/deletion and a (TTTA)n repeat ...
Randi A, Paynter, Susan E, Hankinson, Graham A, Colditz, Peter, Kraft, David J, Hunter, Immaculata, De Vivo   +5 more
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Aromatase activity and CYP19 gene expression in breast cancers

The Journal of Steroid Biochemistry and Molecular Biology, 1996
The aromatase enzyme complex is responsible for the conversion of C19 androgens to oestrogens. Aromatase expression in oestrogen-responsive breast cancers may be an important mechanism of autocrine regulation in tumour growth. To evaluate whether aromatase cytochrome P450 (P450arom) transcript levels within breast tumours were correlated to the enzyme ...
Sourdaine, Pascal, Mullen, Peter, White, Roger, Telford, June, Parker, Malcolm, Miller, William   +5 more
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Expression of CYP19 (Aromatase) mRNA in the Human Temporal Lobe

Biochemical and Biophysical Research Communications, 1998
The conversion of androgens to estrogens by CYP19 (cytochrome P450AROM, aromatase) is an important step in the mechanism of androgen action in the brain. CYP19 expression has been demonstrated in various animal species, but studies in human postnatal brain tissue are lacking.
B, Stoffel-Wagner, M, Watzka, S, Steckelbroeck, R, Schwaab, J, Schramm, F, Bidlingmaier, D, Klingmüller   +6 more
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The effect of opiates on the activity of human placental aromatase/CYP19

Biochemical Pharmacology, 2007
Aromatase, cytochrome P450 19, is a key enzyme in the biosynthesis of estrogens by the human placenta. It is also the major placental enzyme that metabolizes the opiates L-acetylmethadol (LAAM), methadone, and buprenorphine (BUP). Methadone and BUP are used in treatment of the opiate addict and are competitive inhibitors of testosterone conversion to ...
Olga L, Zharikova, Sujal V, Deshmukh, Meena, Kumar, Ricardo, Vargas, Tatiana N, Nanovskaya, Gary D V, Hankins, Mahmoud S, Ahmed   +6 more
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Genetic Profiling of CYP19 Gene Haplotype in Holstein Bulls

Indian Journal of Forensic Medicine & Toxicology, 2021
The CYP19 gene is a protein-coding gene that stimulates the transmutation of androgens to estrogens,aromatase activity is related to haplotypes of the CYP19 gene, therefore this study aimed to detect haplotypesof the CYP19 gene in the Holstein bulls. This study, conducted from October 2018 to June 2019.
null Hassan Nima Habib, null Khalaf A.H.Al-Rishdy, null Murthda F.AL-Hellou   +2 more
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CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis

Fertility and Sterility, 2003
To investigate the possibility of genetic contribution of CYP1A1, CYP19, GSTM1, and GSTT1 polymorphisms to endometriosis.Genetic polymorphism analysis.Case-control study.A group of 275 women with sporadic endometriosis was compared with a group of 346 fertile, endometriosis-free women.Surgical, laparoscopic, and histological examination.Blood specimens
Demetrios A, Arvanitis, Georgios E, Koumantakis, Anastasia G, Goumenou, Ioannis M, Matalliotakis, Eugenios E, Koumantakis, Demetrios A, Spandidos   +5 more
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