Results 171 to 180 of about 13,126 (201)

CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors

Bioorganic & Medicinal Chemistry, 2008
Several derivatives out of a series of antifungal agents exhibited a good inhibitory potency against aromatase as well as a fairly good selectivity toward CYP17, even if lacking H-bond accepting substituents. Their common structural feature is a flexible backbone that did not fit into previously reported CYP19 models.
CASTELLANO, Sabrina, STEFANCICH G, RAGNO R, SCHEWE K, SANTORIELLO M, CAROLI A, HARTMANN R. W, SBARDELLA, Gianluca   +7 more
openaire   +4 more sources

Sox3: A transcription factor for Cyp19 expression in the frog Rana rugosa

Gene, 2009
Cyp19 is expressed at a high level in the gonad of the female tadpole of the frog Rana rugosa during sex determination. To identify sequence elements important for expression of Cyp19, we isolated a genomic clone (approximately 40 kbp) carrying R.
Yuki, Oshima, Kiyoshi, Naruse, Yoriko, Nakamura, Masahisa, Nakamura   +3 more
openaire   +2 more sources

Aromatase (CYP19) expression in tumor-infiltrating lymphocytes and blood mononuclears

Journal of Cancer Research and Clinical Oncology, 2002
To clarify the role of lymphocytes as a possible source of estrogens.In the present study, lymphocytes were isolated from 11 surgical samples of breast cancer after tumor enzyme digestion and Ficoll/Verographine procedure. Simultaneously, using the latter procedure, mononuclears were separated from the blood of 15 female volunteers.Expression of the ...
L M, Berstein, A A, Larionov, T E, Poroshina, T S, Zimarina, E E, Leenman   +4 more
openaire   +2 more sources

Expression of CYP19 (aromatase) mRNA in different areas of the human brain

The Journal of Steroid Biochemistry and Molecular Biology, 1999
The conversion of androgens to estrogens by CYP19 (cytochrome P450AROM, aromatase) is an important step in the mechanism of androgen action in the brain. CYP19 expression has been demonstrated in the brain of various animal species and in the human temporal lobe.
B, Stoffel-Wagner, M, Watzka, J, Schramm, F, Bidlingmaier, D, Klingmüller   +4 more
openaire   +2 more sources

A Novel Polymorphism of the CYP19 Gene is Associated with Essential Hypertension in China

Clinical Laboratory, 2016
Aromatase which is encoded by the CYP19 gene is a key enzyme in the conversion of androgen to estrogen and plays an important role in the balance of the gender hormone levels. The gender hormone has a causal role in the development of cardiovascular disease.
Yan-zhen, Fu, Bei, Wang, Tong-yi, Ma, Ding, Huang, Fen, Liu, Lan-chun, Dong, Ting, Wang, Jie-ya, Meng   +7 more
openaire   +2 more sources

Efficient Expression of Human Aromatase (CYP19) in E. coli

2010
Human aromatase (CYP19, P450arom) is responsible for the conversion of androgens to estrogens. In addition to the estrogen biosynthesis in gonads and adrenals in a classical endocrine manner, this enzyme is widely expressed in various tissues and locally regulates the estrogen level or estrogen/androgen ratio in an intracrine manner.
openaire   +2 more sources

Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro

Toxicology in Vitro, 2000
Many pesticides are able to block or activate the steroid hormone receptors and/or to affect the levels of sex hormones, thereby potentially affecting the development or expression of the male and female reproductive system or both. This emphasizes the relevance of screening pesticides for a wide range of hormone-mimicking effects.
A M, Vinggaard, C, Hnida, V, Breinholt, J C, Larsen   +3 more
openaire   +2 more sources

Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas

Clinical Chemistry and Laboratory Medicine, 2008
Uterine leiomyomas are common, benign, smooth muscle tumors representing a significant public health problem. The aim of this study was to investigate CYP17A1, CYP19, and androgen (AR) polymorphisms, their relative risks for uterine leiomyomas and possible associations with clinical parameters.Uterine leiomyoma tissues and blood samples were obtained ...
Rosa, Fabiola Encinas, Canevari, Renata de Azevedo, Ambrosio, Eliane Papa, Ramos Cirilo, Priscilla Daniele, Pontes, Anaglória, Rainho, Claudia Aparecida, Rogatto, Silvia Regina   +6 more
openaire   +3 more sources

Regulated CYP19 aromatase transcription in breast stromal fibroblasts.

The Journal of clinical endocrinology and metabolism, 2000
Extraglandular estrogen synthesis mediates the proliferation of estrogen-responsive breast cancer in postmenopausal women. Aromatase, the cytochrome P450 Cyp19 enzyme, catalyzes the rate-limiting step in estrogen biosynthesis. Activity is present in both normal and neoplastic breast tissue, and Cyp19 protein is localized by immunohistochemistry ...
R J, Pauley, S J, Santner, L R, Tait, R K, Bright, R J, Santen   +4 more
openaire   +3 more sources

A Candidate Gene Study of CYP19 (Aromatase) and Male Sexual Orientation

Behavior Genetics, 2004
Aromatase cytochrome P450 (CYP19), which is necessary for the conversion of androgens to estrogens, plays an important role in the sexual differentiation of the brain. To investigate whether differences in the gene encoding the aromatase enzyme influence sexual orientation in men, we conducted linkage, association, and expression analyses in a large ...
Michael G, DuPree, Brian S, Mustanski, Sven, Bocklandt, Caroline, Nievergelt, Dean H, Hamer   +4 more
openaire   +2 more sources