Journal of Lipid Research, 2004 There are two major pathways of bile acid synthesis: the “neutral” pathway, initiated by highly regulated microsomal cholesterol 7α-hydroxylase (CYP7A1), and an “alternative” pathway, initiated by mitochondrial sterol 27-hydroxylase (CYP27A1).
Shunlin Ren +6 more
doaj +1 more source
Modules identification in gene positive networks of hepatocellular carcinoma using pearson agglomerative method and Pearson cohesion coupling modularity [PDF]
, 2012 In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes.
Gao, Zhiwei, Hu, Jinyu
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ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer [PDF]
, 2017 Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast ...
Blanco-Vaca, Francisco +7 more
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BMC Neurology, 2011 Background Cerebrotendinous xanthomatosis (CTX) is a rare lipid-storage disease. We investigated the clinic manifestation, histopathology and sterol 27-hydroxylase gene (CYP27A1) in a Chinese family with Cerebrotendinous Xanthomatosis (CTX).
Tian Di, Zhang Zai-qiang
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Abstract 199: Host CYP27A1 expression is essential for ovarian cancer progression
Cancer Research, 2018 Abstract Ovarian cancer continues to have a high mortality and recurrence rate. Hence, there is an urgent need to develop new therapeutic or lifestyle strategies. In this regard, epidemiological studies have implicated elevated cholesterol as a negative prognostic factor.
Sisi He +4 more
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Supplementary Figure S2 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
, 2023 Mahmoud A. Alfaqih +13 more
openalex +2 more sources
Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS ...
A Reboldi +51 more
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Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002 The aim of this study was to explore the regulation of serum cholic acid (CA)/chenodeoxycholic acid (CDCA) ratio in cholestatic hamster induced by ligation of the common bile duct for 48 h. The serum concentration of total bile acids and CA/CDCA ratio were significantly elevated, and the serum proportion of unconjugated bile acids to total bile acids ...
Matsuzaki, Yasushi +9 more
openaire +2 more sources
Supplementary Figure S1 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
, 2023 Mahmoud A. Alfaqih +13 more
openalex +1 more source
Differential expression and co-expression gene networks reveal candidate biomarkers of boar taint in non-castrated pigs [PDF]
, 2017 Boar taint (BT) is an offensive odour or taste observed in pork from a proportion of non-castrated male pigs. Surgical castration is effective in avoiding BT, but animal welfare issues have created an incentive for alternatives such as genomic selection.
Do, Duy N. +4 more
core +3 more sources