Results 171 to 180 of about 49,005 (303)

Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer [PDF]

, 2018
Lucas Soares Bezerra, Marcelo Antônio Oliveira Santos-Veloso, Natanael da Silva Bezerra, Lucilia Carvalho da Fonseca, Wivianne Lisley Andrade Sales   +4 more
openalex   +1 more source

Correction: Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone) [PDF]

, 2021
Maja Matić, Marga Nijenhuis, Bianca Soree, Nienke J. de Boer‐Veger, Anne‐Marie Buunk, Elisa J. F. Houwink, Hans Mulder, Gerard A. Rongen, Jan van der Weide, Bob Wilffert, Jesse J. Swen, Henk‐Jan Guchelaar, Vera H.M. Deneer, Ron H. N. van Schaik   +13 more
openalex   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

CARACTERIZACIÓN DE VARIANTES ALÉLICAS DE CITOCROMO CYP2D6 EN LA POBLACIÓN DE LA REGIÓN CENTROCCIDENTAL DE VENEZUELA

Acta Biológica Colombiana, 2009
RESUMEN El gen CYP2D6 codifica para una monooxigenasa perteneciente al citocromo P450, la cual está involucrada en la biotransformación de un gran número de drogas comúnmente prescritas, como antidepresivos, antineoplásicos y antihipertensivos. Algunos
PEDRO GRIMÁN, YEINMY MORÁN, MARÍA CAMARGO, MIGUEL ANGEL CHIURILLO   +3 more
doaj  

CYP2D6 polymorphism screening in a selected population of Spain (La Alpujarra): No effect of geographical isolation

, 2009
Ana Fernández‐Santander, Francisco Luna, Catalina Santiago, María Teresa Rodríguez, Fernando Bandrés, Jonatan R. Ruiz, Alejandro Lucía, Félix Gómez‐Gallego   +7 more
openalex   +2 more sources

Evaluation of the PK/PD Changes on MASLD‐Related Population—An Example From Simultaneous Acetaminophen Parent‐Metabolite PBPK/PD Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) may exhibit altered pharmacokinetics (PK) and pharmacodynamics (PD) of drugs compared with healthy populations. However, no physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model has been specifically developed for MASLD.
Shanshan Zhao, Lan Zhang
wiley   +1 more source

Estimating the Potential Impact of CYP2C19 and CYP2D6 Genetic Testing on Protocol-Based Care for Depression in Canada and the United States [PDF]

, 2019
Mikayla Fan, Chad Bousman
openalex   +1 more source

Tamsulosin Associated with Interstitial Lung Damage in CYP2D6 Variant Alleles Carriers [PDF]

, 2020
Naomi T. Jessurun, Petal A. Wijnen, Aalt Bast, Eugène van Puijenbroek, Otto Bekers, Marjolein Drent   +5 more
openalex   +1 more source

Physiologically‐Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Gareth J. Lewis, Roxanne C. Jewell, Anu Shilpa Krishnatry, Kunal S. Taskar   +3 more
wiley   +1 more source

Limited predictive value of achieving beneficial plasma (Z)-endoxifen threshold level by CYP2D6 genotyping in tamoxifen-treated Polish women with breast cancer [PDF]

, 2015
Ewa E. Hennig, Magdalena Piątkowska, Jakub Karczmarski, Krzysztof Goryca, E. Brewczynska, Radosław Jaźwiec, Anna Kluska, Robert Omiotek, Agnieszka Paziewska, Michał Dadlez, Jerzy Ostrowski   +10 more
openalex   +1 more source