Results 171 to 180 of about 47,525 (299)
Genetic insights into congenital heart disease: Prevalence, aetiology and clinical implications
Clinical and Translational Discovery, Volume 5, Issue 5, October 2025.The review synthesizes current knowledge on the genetic underpinnings of congenital heart disease, highlighting how modern genomic technologies enhance understanding of CHD pathogenesis and enable earlier diagnosis. We demonstrate how these genetic insights translate to improved clinical care, risk assessment, and genetic counseling for affected ...
Yuan Yuan +8 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 10, October 2025.SCG enhanced the dietary fiber content and provided antioxidant protection against lipid oxidation in beef patties during storage. Molecular docking results also confirmed strong interactions, especially for chlorogenic acid, supporting the potential of SCG as a functional and sustainable ingredient in meat products. ABSTRACT Spent coffee grounds (SCG)
Nazik Meziyet Dilek
wiley +1 more source
Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers [PDF]
, 2001 Staffan Hägg +2 more
openalex +1 more source
Food Science &Nutrition, Volume 13, Issue 10, October 2025.p‐Cymene exhibited a strong affinity for key hepatocellular carcinoma (HCC) targets and induced dose‐dependent cytotoxicity in HepG2 cells while enhancing antioxidant defense mechanisms. The treatment significantly modulated apoptotic and angiogenic markers, notably increasing Caspase‐3 and p53, and suppressing BCL2 and VEGF expression.
Nadia Anwar +7 more
wiley +1 more source
CHANGE IN SUBSTRATE ENANTIO AND REGIOSELECTIVITY FOR VARIOUS HETEROLOGOUS CYP2D6 EXPRESSION SYSTEMS
, 1998 S. Narimatsu +9 more
openalex +2 more sources
Rapid Detection of the C−1496G Polymorphism in the CYP2D6 *2 Allele [PDF]
, 2001 Jeremy D Claassen +3 more
openalex +1 more source
Aripiprazole overdose in Hong Kong: A 10‐year retrospective cohort
Hong Kong Journal of Emergency Medicine, Volume 32, Issue 5, October 2025.Abstract Introduction Aripiprazole is considered to have a favourable safety profile in overdose, with low risks of cardiovascular and neurological toxicity. However, local data are limited, and the impact of co‐ingestants remains insufficiently studied.
Tun Kin Lam, Shan Liu, Chun Fai Hui
wiley +1 more source
Acta Biológica Colombiana, 2009 RESUMEN El gen CYP2D6 codifica para una monooxigenasa perteneciente al citocromo P450, la cual está involucrada en la biotransformación de un gran número de drogas comúnmente prescritas, como antidepresivos, antineoplásicos y antihipertensivos. Algunos
PEDRO GRIMÁN +3 more
doaj
ChemistryOpen, Volume 14, Issue 10, October 2025.This work investigates the selective inhibition of MAO enzymes by varying the substitution of electron‐withdrawing and donating groups on the phenyl rings of tetrahydropyridines (4 a–4 o). Compounds 4 l and 4 n exhibit promising IC50 values of 0.40±0.05 and 1.01±0.03 μM against MAO‐A and MAO‐B, respectively.
Obaid ur Rehman Khan +10 more
wiley +1 more source
Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms
Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum +4 more
wiley +1 more source