Results 221 to 230 of about 48,854 (243)

A Complete Picture of the CYP2D6 Heterogeneity in Northeastern Italian Genetic Isolates. [PDF]

Int J Mol Sci
Tesolin P, Nardone GG, Santin A, Pecori A, Ruberto R, Concas MP, Zampieri S, Girotto G.   +7 more
europepmc   +1 more source

Influence of CYP2d6 on drug metabolism and methods for determining its activity

, 2018
Smirnov Vv, R. H. Abdrashitov, Е. А. Егоренков, G. N. Gildeeva, G. V. Rаmenskаya, R. A. Permyakov   +5 more
openalex   +1 more source

CYP2D6 variants in amyotrophic lateral sclerosis: an association study of risk and survival

Vallikivi JK, Kooyman M, Project MinE ALS Sequencing Consortium, Iacoangeli A, Al-Chalabi A, Al Khleifat A.   +5 more
europepmc   +1 more source

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Understanding CYP2D6 interactions

Drug Discovery Today, 2009
Owing to the polymorphic nature of CYP2D6, clinically significant issues can arise when drugs rely on that enzyme either for clearance, or metabolism to an active metabolite. Available screening methods to determine if the compound is likely to cause drug-drug interactions, or is likely to be a victim of inhibition of CYP2D6 by other compounds will be ...
Marcel J, de Groot, Florian, Wakenhut, Gavin, Whitlock, Ruth, Hyland   +3 more
openaire   +2 more sources

CYP2D6*36 GENE ARRANGEMENTS WITHIN THE CYP2D6 LOCUS: ASSOCIATION OF CYP2D6*36 WITH POOR METABOLIZER STATUS

Drug Metabolism and Disposition, 2006
Unexplained cases of CYP2D6 genotype/phenotype discordance continue to be discovered. In previous studies, several African Americans with a poor metabolizer phenotype carried the reduced function CYP2D6*10 allele in combination with a nonfunctional allele.
Andrea, Gaedigk, L Dianne, Bradford, Sarah W, Alander, J Steven, Leeder   +3 more
openaire   +2 more sources

Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6*2 and/or CYP2D6*10 alleles

Drug Metabolism and Pharmacokinetics, 2002
Novel single nucleotide polymorphisms (SNPs) were found in introns 1, 3, 4, 5, and 7 of the gene encoding cytochrome (CYP) 2D6 in 90 Japanese subjects. Some of these SNPs were associated with C2850T and/or C100T, which are key SNPs for CYP2D6(*)2 and CYP2D6(*)10, respectively.
Akiko, Soyama, Yoshiro, Saito, Kazuo, Komamura, Kazuyuki, Ueno, Shiro, Kamakura, Shogo, Ozawa, Jun-ichi, Sawada   +6 more
openaire   +2 more sources

Induction of CYP2D6 in pregnancy*

Clinical Pharmacology & Therapeutics, 1997
Expression of the drug-metabolizing enzyme cytochrome P4502D6 (CYP2D6) is predominantly under genetic control, and enzyme-inducing drugs have little influence on its activity. We studied the activity of CYP2D6 during pregnancy. One hundred forty pregnant women were genotyped for CYP2D6.
M, Wadelius, E, Darj, G, Frenne, A, Rane
openaire   +2 more sources