Results 21 to 30 of about 61,480 (319)

Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6β-Hydroxylation

Drug Metabolism And Disposition, 2020
CYP3A4 is among the most abundant liver and intestinal drug-metabolizing cytochrome P450 enzymes, contributing to the metabolism of more than 30% of clinically used drugs.
Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, D. Saigusa, Shu Tadaka, K. Kinoshita, T. Nakayoshi, A. Oda, Ai Abe, Masamitsu Maekawa, N. Mano, N. Hirasawa, M. Hiratsuka   +14 more
semanticscholar   +1 more source

Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway

World Journal of Traditional Chinese Medicine, 2021
Objective: To explore the mechanism underlying the effect of Panax notoginseng saponins (PNS) on the pharmacokinetics of nifedipine (NF) in rats. Materials and Methods: Twenty-four rats were randomly divided into blank (BL) group, PNS group, NF group ...
Qiu-Hong Li, Jiao Zhao, Ai-Xia Ju, Yong Hu, Qing-Song Qie, Hong-Bin Xiao, Guang Xu, Xi-Jun Wang   +7 more
doaj   +1 more source

Imidazopyridines as selective CYP3A4 inhibitors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2012
Cytochrome P450s are the major family of enzymes responsible for the oxidative metabolism of pharmaceuticals and xenobiotics. CYP3A4 and CYP3A5 have been shown to have overlapping substrate and inhibitor profiles and their inhibition has been demonstrated to be involved in numerous pharmacokinetic drug-drug interactions. Here we report the first highly
Xinyi, Song, Xiaohai, Li, Claudia H, Ruiz, Yan, Yin, Yangbo, Feng, Theodore M, Kamenecka, Michael D, Cameron   +6 more
openaire   +2 more sources

The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

Pharmaceutical Biology, 2021
Context The interaction between nobiletin and anemarsaponin BII could affect the pharmacological activity of these two drugs during their combination.
Jie Zhang, Meiling Fan, Xia Yu, Bin Zhang   +3 more
doaj   +1 more source

In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2017
Context: Dihydromyricetin (DHM) is the most abundant and active flavonoid component isolated from Ampelopsis grossedentata (Hand-Mazz) W.T. Wang (Vitaceae) and it possesses numerous pharmacological activities. However, whether DHM affects the activity of
Lu Liu, Sen Sun, Hongbing Rui, Xiaohua Li   +3 more
doaj   +1 more source

Enhanced oral bioavailability of nisoldipine-piperine-loaded poly-lactic-co-glycolic acid nanoparticles

Nanotechnology Reviews, 2017
Piperine helps in the improvement of bioavailability through pharmacokinetic interaction by modulating metabolism when administered with other drugs. Nisoldipine is a substrate for cytochrome P4503A4 enzymes.
Rathee Permender, Kamboj Anjoo, Sidhu Shabir   +2 more
doaj   +1 more source

Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: In recent years, a number of natural medicines have been reported to have inductive or inhibitive effects on the activity of drug metabolizing enzymes, upon co-administration with prescribed medicines.
Yu Sato, Takamitsu Sasaki, Shogo Takahashi, Takeshi Kumagai, Kiyoshi Nagata   +4 more
doaj   +1 more source

In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2018
Context: Friedelin is a triterpenoid with several biological activities. However, the affects of Friedelin on the activity of human liver cytochrome P450 (CYP) enzymes remains unclear.
Jinlan Wei, Hongying Zhang, Qingling Zhao   +2 more
doaj   +1 more source

A Review on the Potential of Application of CRISPR/Cas9 Technology in CYP3A4 and CYP2D6 Genes: A Way to Move Forward in Identifying New Drug Targets

ASM Science Journal, 2022
The cytochrome P450 (CYP) enzymes are of a ubiquitous heme–thiolate proteins family that plays an important role within the biotransformation of endogenous molecules and xenobiotics as today’s market is bio-transformed through CYP-mediated metabolism ...
Fazleen Haslinda Mohd Hatta, Ahmad Azani Othman, Rosmadi Mohd Yusoff, Siti Norsyuhada Nor Azam, Aliah Zuhairah Ali Hassan   +4 more
doaj   +1 more source

Role of CYP3A4 in bone marrow microenvironment-mediated protection of FLT3/ITD AML from tyrosine kinase inhibitors.

Blood Advances, 2019
An intriguing aspect of the clinical activity of FMS-like tyrosine kinase 3 inhibitors (FLT3 TKIs) is their apparent higher activity against peripheral blasts from FLT3/internal tandem duplication (ITD) acute myeloid leukemia than marrow disease in the ...
Yu-Ting Chang, D. Hernandez, S. Alonso, Minling Gao, Meng Su, G. Ghiaur, M. Levis, Richard J. Jones   +7 more
semanticscholar   +1 more source